Chronic airflow obstruction and markers of systemic inflammation: results from the BOLD study in Iceland.

2.50
Hdl Handle:
http://hdl.handle.net/2336/81379
Title:
Chronic airflow obstruction and markers of systemic inflammation: results from the BOLD study in Iceland.
Authors:
Thorleifsson, Sigurdur James; Margretardottir, Olof Birna; Gudmundsson, Gunnar; Olafsson, Isleifur; Benediktsdottir, Bryndis; Janson, Christer; Buist, A Sonia; Gislason, Thorarinn
Citation:
Respir Med. 2009, 103(10):1548-53
Issue Date:
1-Oct-2009
Abstract:
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible chronic airflow obstruction and by an accelerated decline in lung function. Elevated circulating levels of C-reactive protein (CRP) and interleukin-6 (IL-6), both markers of systemic inflammation, have been found in COPD. Their possible associations with chronic airflow obstruction have mostly been evaluated in highly selected patient samples. Our objective was to evaluate the association between postbronchodilator lung function CRP and IL-6 in a randomly selected sample of the Icelandic population, 40 years and older, while adjusting for gender, age, smoking, and body weight. METHODS: Serum CRP and IL-6 values were measured among participants in the Burden of Obstructive Lung Disease (BOLD) study. RESULTS: Of the 938 subjects invited a total of 403 men and 355 women participated (response rate 81%) in the study. Their mean age (+/-SD) was 57.7 (+/-12.7) years. Both CRP and IL-6 were independently related to lower FEV1 and FVC values. Individuals in the highest quartiles of CRP and IL-6 had a 7.5% and 3.9%, respectively, lower FEV1% than predicted after adjustment for smoking, age, and body weight. High CRP levels were more strongly related to lower FEV1 levels in men (-11.4%) than in women (-0.4%). CONCLUSIONS: In a random population-based sample both CRP and IL-6 were significantly related to lower spirometric values. The association with CRP was stronger in men than in women. This finding underscores the possible importance of systemic inflammation in irreversible airflow limitation.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1016/j.rmed.2009.04.005

Full metadata record

DC FieldValue Language
dc.contributor.authorThorleifsson, Sigurdur James-
dc.contributor.authorMargretardottir, Olof Birna-
dc.contributor.authorGudmundsson, Gunnar-
dc.contributor.authorOlafsson, Isleifur-
dc.contributor.authorBenediktsdottir, Bryndis-
dc.contributor.authorJanson, Christer-
dc.contributor.authorBuist, A Sonia-
dc.contributor.authorGislason, Thorarinn-
dc.date.accessioned2009-09-17T11:44:07Z-
dc.date.available2009-09-17T11:44:07Z-
dc.date.issued2009-10-01-
dc.date.submitted2009-09-17-
dc.identifier.citationRespir Med. 2009, 103(10):1548-53en
dc.identifier.issn1532-3064-
dc.identifier.pmid19427181-
dc.identifier.doi10.1016/j.rmed.2009.04.005-
dc.identifier.urihttp://hdl.handle.net/2336/81379-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible chronic airflow obstruction and by an accelerated decline in lung function. Elevated circulating levels of C-reactive protein (CRP) and interleukin-6 (IL-6), both markers of systemic inflammation, have been found in COPD. Their possible associations with chronic airflow obstruction have mostly been evaluated in highly selected patient samples. Our objective was to evaluate the association between postbronchodilator lung function CRP and IL-6 in a randomly selected sample of the Icelandic population, 40 years and older, while adjusting for gender, age, smoking, and body weight. METHODS: Serum CRP and IL-6 values were measured among participants in the Burden of Obstructive Lung Disease (BOLD) study. RESULTS: Of the 938 subjects invited a total of 403 men and 355 women participated (response rate 81%) in the study. Their mean age (+/-SD) was 57.7 (+/-12.7) years. Both CRP and IL-6 were independently related to lower FEV1 and FVC values. Individuals in the highest quartiles of CRP and IL-6 had a 7.5% and 3.9%, respectively, lower FEV1% than predicted after adjustment for smoking, age, and body weight. High CRP levels were more strongly related to lower FEV1 levels in men (-11.4%) than in women (-0.4%). CONCLUSIONS: In a random population-based sample both CRP and IL-6 were significantly related to lower spirometric values. The association with CRP was stronger in men than in women. This finding underscores the possible importance of systemic inflammation in irreversible airflow limitation.en
dc.language.isoenen
dc.publisherW.B. Saundersen
dc.relation.urlhttp://dx.doi.org/10.1016/j.rmed.2009.04.005en
dc.subject.meshPulmonary Disease, Chronic Obstructiveen
dc.titleChronic airflow obstruction and markers of systemic inflammation: results from the BOLD study in Iceland.en
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.en
dc.identifier.journalRespiratory medicineen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.