Risk factors for five-year incident age-related macular degeneration: the Reykjavik Eye Study

2.50
Hdl Handle:
http://hdl.handle.net/2336/82836
Title:
Risk factors for five-year incident age-related macular degeneration: the Reykjavik Eye Study
Authors:
Arnarsson, Arsaell; Sverrisson, Thordur; Stefansson, Einar; Sigurdsson, Haraldur; Sasaki, Hiroshi; Sasaki, Kazuyuki; Jonasson, Fridbert
Citation:
Am. J. Ophthalmol. 2006, 142(3):419-28
Issue Date:
1-Sep-2006
Abstract:
PURPOSE: To establish risk factors for five-year incidence of age-related macular degeneration (AMD). DESIGN: Population-based, prospective cohort study, and risk analysis. METHODS: A random sample from the Reykjavik Population Census for individuals 50 years and older was selected. We took fundus stereo color photographs and used standard grading system to study the five-year incidence of drusen, pigmentary abnormalities, and AMD and to examine possible risk factors. A questionnaire including information on disease, medication, diet, and lifestyle from the Reykjavik Eye Study database provided additional information. RESULTS: Current alcohol consumption decreased the risk for drusen. Being married rather than divorced or widowed decreased the risk for soft drusen; being single decreased the risk of hypopigmentation as compared with being divorced or married. Both consuming dietary fiber-rich vegetables and meat and meat products once a week or less frequently was a risk factor for developing soft drusen and decreased the risk of pigmentary abnormalities. Those who had smoked 20 pack-years or more as compared with nonsmokers had decreased survival rate over the five years (odds ratio (OR) 0.46, 95% confidence interval (CI) 0.27 to 0.80; P = .006). CONCLUSIONS: Risk factors for drusen appear to differ from risk factors for pigmentary abnormalities. The effect of smoking on developing AMD is partly masked by selective mortality.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1016/j.ajo.2006.04.015

Full metadata record

DC FieldValue Language
dc.contributor.authorArnarsson, Arsaellen
dc.contributor.authorSverrisson, Thorduren
dc.contributor.authorStefansson, Einaren
dc.contributor.authorSigurdsson, Haralduren
dc.contributor.authorSasaki, Hiroshien
dc.contributor.authorSasaki, Kazuyukien
dc.contributor.authorJonasson, Fridberten
dc.date.accessioned2009-09-28T11:00:52Z-
dc.date.available2009-09-28T11:00:52Z-
dc.date.issued2006-09-01-
dc.date.submitted2009-09-28-
dc.identifier.citationAm. J. Ophthalmol. 2006, 142(3):419-28en
dc.identifier.issn0002-9394-
dc.identifier.pmid16935586-
dc.identifier.doi10.1016/j.ajo.2006.04.015-
dc.identifier.urihttp://hdl.handle.net/2336/82836-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: To establish risk factors for five-year incidence of age-related macular degeneration (AMD). DESIGN: Population-based, prospective cohort study, and risk analysis. METHODS: A random sample from the Reykjavik Population Census for individuals 50 years and older was selected. We took fundus stereo color photographs and used standard grading system to study the five-year incidence of drusen, pigmentary abnormalities, and AMD and to examine possible risk factors. A questionnaire including information on disease, medication, diet, and lifestyle from the Reykjavik Eye Study database provided additional information. RESULTS: Current alcohol consumption decreased the risk for drusen. Being married rather than divorced or widowed decreased the risk for soft drusen; being single decreased the risk of hypopigmentation as compared with being divorced or married. Both consuming dietary fiber-rich vegetables and meat and meat products once a week or less frequently was a risk factor for developing soft drusen and decreased the risk of pigmentary abnormalities. Those who had smoked 20 pack-years or more as compared with nonsmokers had decreased survival rate over the five years (odds ratio (OR) 0.46, 95% confidence interval (CI) 0.27 to 0.80; P = .006). CONCLUSIONS: Risk factors for drusen appear to differ from risk factors for pigmentary abnormalities. The effect of smoking on developing AMD is partly masked by selective mortality.en
dc.language.isoenen
dc.publisherElsevier Scienceen
dc.relation.urlhttp://dx.doi.org/10.1016/j.ajo.2006.04.015en
dc.subject.meshAgeden
dc.subject.meshDieten
dc.subject.meshDiet Recordsen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshIncidenceen
dc.subject.meshMacular Degenerationen
dc.subject.meshMiddle Ageden
dc.subject.meshProspective Studiesen
dc.subject.meshQuestionnairesen
dc.subject.meshRetinal Drusenen
dc.subject.meshRisk Factorsen
dc.subject.meshSmokingen
dc.titleRisk factors for five-year incident age-related macular degeneration: the Reykjavik Eye Studyen
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, University of Iceland, Reykjavik, Iceland.en
dc.identifier.journalAmerican journal of ophthalmologyen

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