Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing.

2.50
Hdl Handle:
http://hdl.handle.net/2336/82858
Title:
Indomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing.
Authors:
Pedersen, D B; Eysteinsson, T; Stefansson, E; Kiilgaard, J F; La Cour, M; Bang, K; Jensen, P K
Citation:
Br J Ophthalmol. 2004, 88(8):1088-91
Issue Date:
1-Aug-2004
Abstract:
BACKGROUND/AIMS: Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig. METHODS: Optic nerve oxygen tension was measured in 11 pigs with a polarographic oxygen electrode. The tip of the electrode was placed 0.5 mm above the optic disc. The effects of indomethacin, CO(2) breathing (3%) before and after indomethacin treatment, and carbonic anhydrase inhibition with or without indomethacin treatment were investigated. RESULTS: Administration of 300 mg indomethacin decreased optic nerve oxygen tension significantly. Carbonic anhydrase inhibition and CO(2) breathing increased ONPO(2) significantly. After indomethacin had been given, the rise in ONPO(2) caused by CO(2) breathing and carbonic anhydrase inhibition was significantly reduced. CONCLUSION: Systemic administration of indomethacin decreases the optic nerve oxygen tension; this is probably the result of decreased blood flow through vasoconstriction of vessels in the optic nerve. Additionally, indomethacin diminishes the ONPO(2) increasing effect of CO(2) breathing and carbonic anhydrase inhibition, thus affecting the reactivity of vessels in the optic nerve.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1136/bjo.2003.041251

Full metadata record

DC FieldValue Language
dc.contributor.authorPedersen, D Ben
dc.contributor.authorEysteinsson, Ten
dc.contributor.authorStefansson, Een
dc.contributor.authorKiilgaard, J Fen
dc.contributor.authorLa Cour, Men
dc.contributor.authorBang, Ken
dc.contributor.authorJensen, P Ken
dc.date.accessioned2009-09-28T14:56:42Z-
dc.date.available2009-09-28T14:56:42Z-
dc.date.issued2004-08-01-
dc.date.submitted2009-09-28-
dc.identifier.citationBr J Ophthalmol. 2004, 88(8):1088-91en
dc.identifier.issn0007-1161-
dc.identifier.pmid15258031-
dc.identifier.doi10.1136/bjo.2003.041251-
dc.identifier.urihttp://hdl.handle.net/2336/82858-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND/AIMS: Prostaglandins are important in blood flow regulation. Carbon dioxide (CO(2)) breathing and carbonic anhydrase inhibition increase the oxygen tension in the retina and optic nerve. To study the mechanism of this effect and the role of cyclo-oxygenase in the regulation of optic nerve oxygen tension (ONPO(2)), the authors investigated how indomethacin affects ONPO(2) and the ONPO(2) increases caused by CO(2) breathing and carbonic anhydrase inhibition in the pig. METHODS: Optic nerve oxygen tension was measured in 11 pigs with a polarographic oxygen electrode. The tip of the electrode was placed 0.5 mm above the optic disc. The effects of indomethacin, CO(2) breathing (3%) before and after indomethacin treatment, and carbonic anhydrase inhibition with or without indomethacin treatment were investigated. RESULTS: Administration of 300 mg indomethacin decreased optic nerve oxygen tension significantly. Carbonic anhydrase inhibition and CO(2) breathing increased ONPO(2) significantly. After indomethacin had been given, the rise in ONPO(2) caused by CO(2) breathing and carbonic anhydrase inhibition was significantly reduced. CONCLUSION: Systemic administration of indomethacin decreases the optic nerve oxygen tension; this is probably the result of decreased blood flow through vasoconstriction of vessels in the optic nerve. Additionally, indomethacin diminishes the ONPO(2) increasing effect of CO(2) breathing and carbonic anhydrase inhibition, thus affecting the reactivity of vessels in the optic nerve.en
dc.language.isoenen
dc.publisherBritish Medical Associationen
dc.relation.urlhttp://dx.doi.org/10.1136/bjo.2003.041251en
dc.subject.meshAnimalsen
dc.subject.meshCarbon Dioxideen
dc.subject.meshCarbonic Anhydrase Inhibitorsen
dc.subject.meshCyclooxygenase Inhibitorsen
dc.subject.meshIndomethacinen
dc.subject.meshOptic Nerveen
dc.subject.meshOxygenen
dc.subject.meshSwineen
dc.titleIndomethacin lowers optic nerve oxygen tension and reduces the effect of carbonic anhydrase inhibition and carbon dioxide breathing.en
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, 2061, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. daniella@dadlnet.dken
dc.identifier.journalBritish journal of ophthalmologyen

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