The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology

2.50
Hdl Handle:
http://hdl.handle.net/2336/82937
Title:
The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology
Authors:
Stefansson, E
Citation:
Acta Ophthalmol Scand. 2001, 79(5):435-40
Issue Date:
1-Oct-2001
Abstract:
The physiologic mechanism of photocoagulation can been seen in the following steps. The physical light energy is absorbed in the melanin of the retinal pigment epithelium. The adjacent photoreceptors are destroyed and are replaced by a glial scar and the oxygen consumption of the outer retina is reduced. Oxygen that normally diffuses from the choriocapillaris into the retina can now diffuse through the laser scars in the photoreceptor layer without being consumed in the mitochondria of the photoreceptors. This oxygen flux reaches the inner retina to relieve inner retinal hypoxia and raise the oxygen tension. As a result, the retinal arteries constrict and the bloodflow decreases. Hypoxia relief reduces production of growth factors such as VEGF and neovascularization is reduced or stopped. Vasoconstriction increases arteriolar resistance, decreases hydrostatic pressure in capillaries and venules and reduces edema formation according to Starling's law. Vitrectomy also improves retinal oxygenation by allowing oxygen and other nutrients to be transported in water currents in the vitreous cavity from well oxygenated to ischemic areas of the retina. Vitrectomy and retinal photocoagulation both improve retinal oxygenation and both reduce diabetic macular edema and retinal neovascularization.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www3.interscience.wiley.com/journal/120709497/abstract

Full metadata record

DC FieldValue Language
dc.contributor.authorStefansson, Een
dc.date.accessioned2009-09-29T11:46:07Z-
dc.date.available2009-09-29T11:46:07Z-
dc.date.issued2001-10-01-
dc.date.submitted2009-09-29-
dc.identifier.citationActa Ophthalmol Scand. 2001, 79(5):435-40en
dc.identifier.issn1395-3907-
dc.identifier.pmid11594975-
dc.identifier.doi10.1111/j.1600-0420.2001.790502.x-
dc.identifier.urihttp://hdl.handle.net/2336/82937-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe physiologic mechanism of photocoagulation can been seen in the following steps. The physical light energy is absorbed in the melanin of the retinal pigment epithelium. The adjacent photoreceptors are destroyed and are replaced by a glial scar and the oxygen consumption of the outer retina is reduced. Oxygen that normally diffuses from the choriocapillaris into the retina can now diffuse through the laser scars in the photoreceptor layer without being consumed in the mitochondria of the photoreceptors. This oxygen flux reaches the inner retina to relieve inner retinal hypoxia and raise the oxygen tension. As a result, the retinal arteries constrict and the bloodflow decreases. Hypoxia relief reduces production of growth factors such as VEGF and neovascularization is reduced or stopped. Vasoconstriction increases arteriolar resistance, decreases hydrostatic pressure in capillaries and venules and reduces edema formation according to Starling's law. Vitrectomy also improves retinal oxygenation by allowing oxygen and other nutrients to be transported in water currents in the vitreous cavity from well oxygenated to ischemic areas of the retina. Vitrectomy and retinal photocoagulation both improve retinal oxygenation and both reduce diabetic macular edema and retinal neovascularization.en
dc.language.isoenen
dc.publisherBlackwellen
dc.relation.urlhttp://www3.interscience.wiley.com/journal/120709497/abstracten
dc.subject.meshDiabetic Retinopathyen
dc.subject.meshEyeen
dc.subject.meshHumansen
dc.subject.meshLaser Coagulationen
dc.subject.meshMacular Edemaen
dc.subject.meshModels, Biologicalen
dc.subject.meshOxygenen
dc.subject.meshRetinal Neovascularizationen
dc.subject.meshRetinal Vein Occlusionen
dc.subject.meshRetinal Vesselsen
dc.subject.meshVitrectomyen
dc.subject.meshVitreous Bodyen
dc.titleThe therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiologyen
dc.typeArticleen
dc.contributor.departmentDepartment of Ophthalmology, Landspitali, University of Iceland, Reykjavik, Iceland. estefans@hi.isen
dc.identifier.journalActa ophthalmologica Scandinavicaen

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