2.50
Hdl Handle:
http://hdl.handle.net/2336/8330
Title:
No evidence of association between genetic variants of the PDCD1 ligands and SLE
Authors:
Abelson, A K; Johansson, C M; Kozyrev, S V; Kristjansdottir, H; Gunnarsson, I; Svenungsson, E; Jönsen, A; Lima, G; Scherbarth, H R; Gamron, S; Allievi, A; Palatnik, S A; Alvarellos, A; Paira, S; Graf, C; Guillerón, C; Catoggio, L J; Prigione, C; Battagliotti, C G; Berbotto, G A; García, M A; Perandones, C E; Truedsson, L; Steinsson, K; Sturfelt, G; Pons-Estel, B; Alarcón-Riquelme, M E
Citation:
Genes Immun. 2007, 8(1):69-74
Issue Date:
1-Jan-2007
Abstract:
PDCD1, an immunoreceptor involved in peripheral tolerance has previously been shown to be genetically associated with systemic lupus erythematosus (SLE). PDCD1 has two ligands whose genes are located in close proximity on chromosome 9p24. Our attention was drawn to these ligands after finding suggestive linkage to a marker (gata62f03, Z=2.27) located close to their genes in a genome scan of Icelandic families multiplex for SLE. Here, we analyse Swedish trios (N=149) for 23 single nucleotide polymorphisms (SNPs) within the genes of the PDCD1 ligands. Initially, indication of association to eight SNPs was observed, and these SNPs were therefore also analysed in Mexican trios (N=90), as well as independent sets of patients and controls from Sweden (152 patients, 448 controls) and Argentina (288 patients, 288 controls). We do not find support for genetic association to SLE. This is the first genetic study of SLE and the PDCD1 ligands and the lack of association in several cohorts implies that these genes are not major risk factors for SLE.Genes and Immunity (2007) 8, 69-74. doi:10.1038/sj.gene.6364360; published online 30 November 2006.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.nature.com/gene/journal/v8/n1/full/6364360a.html

Full metadata record

DC FieldValue Language
dc.contributor.authorAbelson, A K-
dc.contributor.authorJohansson, C M-
dc.contributor.authorKozyrev, S V-
dc.contributor.authorKristjansdottir, H-
dc.contributor.authorGunnarsson, I-
dc.contributor.authorSvenungsson, E-
dc.contributor.authorJönsen, A-
dc.contributor.authorLima, G-
dc.contributor.authorScherbarth, H R-
dc.contributor.authorGamron, S-
dc.contributor.authorAllievi, A-
dc.contributor.authorPalatnik, S A-
dc.contributor.authorAlvarellos, A-
dc.contributor.authorPaira, S-
dc.contributor.authorGraf, C-
dc.contributor.authorGuillerón, C-
dc.contributor.authorCatoggio, L J-
dc.contributor.authorPrigione, C-
dc.contributor.authorBattagliotti, C G-
dc.contributor.authorBerbotto, G A-
dc.contributor.authorGarcía, M A-
dc.contributor.authorPerandones, C E-
dc.contributor.authorTruedsson, L-
dc.contributor.authorSteinsson, K-
dc.contributor.authorSturfelt, G-
dc.contributor.authorPons-Estel, B-
dc.contributor.authorAlarcón-Riquelme, M E-
dc.date.accessioned2007-02-12T12:43:48Z-
dc.date.available2007-02-12T12:43:48Z-
dc.date.issued2007-01-01-
dc.date.submitted2007-02-12-
dc.identifier.citationGenes Immun. 2007, 8(1):69-74en
dc.identifier.issn1466-4879-
dc.identifier.pmid17136123-
dc.identifier.doi10.1038/sj.gene.6364360-
dc.identifier.otherRHE12-
dc.identifier.urihttp://hdl.handle.net/2336/8330-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPDCD1, an immunoreceptor involved in peripheral tolerance has previously been shown to be genetically associated with systemic lupus erythematosus (SLE). PDCD1 has two ligands whose genes are located in close proximity on chromosome 9p24. Our attention was drawn to these ligands after finding suggestive linkage to a marker (gata62f03, Z=2.27) located close to their genes in a genome scan of Icelandic families multiplex for SLE. Here, we analyse Swedish trios (N=149) for 23 single nucleotide polymorphisms (SNPs) within the genes of the PDCD1 ligands. Initially, indication of association to eight SNPs was observed, and these SNPs were therefore also analysed in Mexican trios (N=90), as well as independent sets of patients and controls from Sweden (152 patients, 448 controls) and Argentina (288 patients, 288 controls). We do not find support for genetic association to SLE. This is the first genetic study of SLE and the PDCD1 ligands and the lack of association in several cohorts implies that these genes are not major risk factors for SLE.Genes and Immunity (2007) 8, 69-74. doi:10.1038/sj.gene.6364360; published online 30 November 2006.en
dc.language.isoenen
dc.publisherNature Pub. Groupen
dc.relation.urlhttp://www.nature.com/gene/journal/v8/n1/full/6364360a.htmlen
dc.subject.meshAntigens, CDen
dc.subject.meshApoptosis Regulatory Proteinsen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshIntercellular Signaling Peptides and Proteinsen
dc.subject.meshLupus Erythematosus, Systemicen
dc.titleNo evidence of association between genetic variants of the PDCD1 ligands and SLEen
dc.typeArticleen
dc.format.digYES-

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