Comparison of spirometry criteria for the diagnosis of COPD: results from the BOLD study

2.50
Hdl Handle:
http://hdl.handle.net/2336/83347
Title:
Comparison of spirometry criteria for the diagnosis of COPD: results from the BOLD study
Authors:
Vollmer, W M; Gislason, T; Burney, P; Enright, P L; Gulsvik, A; Kocabas, A; Buist, A S
Citation:
Eur. Respir. J. 2009, 34(3):588-97
Issue Date:
1-Sep-2009
Abstract:
Published guidelines recommend spirometry to accurately diagnose chronic obstructive pulmonary disease (COPD). However, even spirometry-based COPD prevalence estimates can vary widely. We compared properties of several spirometry-based COPD definitions using data from the international Burden of Obstructive Lung Disease (BOLD)study. 14 sites recruited population-based samples of adults aged > or =40 yrs. Procedures included standardised questionnaires and post-bronchodilator spirometry. 10,001 individuals provided usable data. Use of the lower limit of normal (LLN) forced expiratory volume in 1 s (FEV(1)) to forced vital capacity (FVC) ratio reduced the age-related increases in COPD prevalence that are seen among healthy never-smokers when using the fixed ratio criterion (FEV(1)/FVC <0.7) recommended by the Global Initiative for Chronic Obstructive Lung Disease. The added requirement of an FEV(1) either <80% predicted or below the LLN further reduced age-related increases and also led to the least site-to-site variability in prevalence estimates after adjusting for potential confounders. Use of the FEV(1)/FEV(6) ratio in place of the FEV(1)/FVC yielded similar prevalence estimates. Use of the FEV(1)/FVC<LLN criterion instead of the FEV(1)/FVC <0.7 should minimise known age biases and better reflect clinically significant irreversible airflow limitation. Our study also supports the use of the FEV(1)/FEV(6) as a practical substitute for the FEV(1)/FVC.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1183/09031936.00164608

Full metadata record

DC FieldValue Language
dc.contributor.authorVollmer, W Men
dc.contributor.authorGislason, Ten
dc.contributor.authorBurney, Pen
dc.contributor.authorEnright, P Len
dc.contributor.authorGulsvik, Aen
dc.contributor.authorKocabas, Aen
dc.contributor.authorBuist, A Sen
dc.date.accessioned2009-10-02T15:36:46Z-
dc.date.available2009-10-02T15:36:46Z-
dc.date.issued2009-09-01-
dc.date.submitted2009-10-02-
dc.identifier.citationEur. Respir. J. 2009, 34(3):588-97en
dc.identifier.issn0903-1936-
dc.identifier.pmid19460786-
dc.identifier.doi10.1183/09031936.00164608-
dc.identifier.urihttp://hdl.handle.net/2336/83347-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPublished guidelines recommend spirometry to accurately diagnose chronic obstructive pulmonary disease (COPD). However, even spirometry-based COPD prevalence estimates can vary widely. We compared properties of several spirometry-based COPD definitions using data from the international Burden of Obstructive Lung Disease (BOLD)study. 14 sites recruited population-based samples of adults aged > or =40 yrs. Procedures included standardised questionnaires and post-bronchodilator spirometry. 10,001 individuals provided usable data. Use of the lower limit of normal (LLN) forced expiratory volume in 1 s (FEV(1)) to forced vital capacity (FVC) ratio reduced the age-related increases in COPD prevalence that are seen among healthy never-smokers when using the fixed ratio criterion (FEV(1)/FVC <0.7) recommended by the Global Initiative for Chronic Obstructive Lung Disease. The added requirement of an FEV(1) either <80% predicted or below the LLN further reduced age-related increases and also led to the least site-to-site variability in prevalence estimates after adjusting for potential confounders. Use of the FEV(1)/FEV(6) ratio in place of the FEV(1)/FVC yielded similar prevalence estimates. Use of the FEV(1)/FVC<LLN criterion instead of the FEV(1)/FVC <0.7 should minimise known age biases and better reflect clinically significant irreversible airflow limitation. Our study also supports the use of the FEV(1)/FEV(6) as a practical substitute for the FEV(1)/FVC.en
dc.language.isoenen
dc.publisherEuropean Respiratory Societyen
dc.relation.urlhttp://dx.doi.org/10.1183/09031936.00164608en
dc.subject.meshPulmonary Disease, Chronic Obstructiveen
dc.titleComparison of spirometry criteria for the diagnosis of COPD: results from the BOLD studyen
dc.typeArticleen
dc.identifier.eissn1399-3003-
dc.contributor.departmentKaiser Permanente, Center for Health Research, Portland, OR 97227-1110, USA. william.vollmer@kpchr.orgen
dc.identifier.journalEuropean respiratory journal : official journal of the European Society for Clinical Respiratory Physiologyen

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