A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13

2.50
Hdl Handle:
http://hdl.handle.net/2336/84473
Title:
A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13
Authors:
Arngrimsson, R; Sigurardottir, S; Frigge, M L; Bjarnad ttir, R I; Jonsson, T; Stefansson, H; Baldursdottir, A; Einarsdottir, A S; Palsson, B; Snorradottir, S; Lachmeijer, A M; Nicolae, D; Kong, A; Bragason, B T; Gulcher, J R; Geirsson, R T; Stefansson, K
Citation:
Hum. Mol. Genet. 1999, 8(9):1799-805
Issue Date:
1-Sep-1999
Abstract:
Pre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and proteinuria. Unlike most other human disorders it impacts two individuals, the mother and the child, both of whom can be severely affected. The pathophysiology of the disorder is incompletely understood, but familial clustering of the disease is apparent. Here we report the results of a genome-wide screen of Icelandic families representing 343 affected women. Including those patients with non-proteinuric pre-eclampsia (gestational hypertension), proteinuric pre-eclampsia and eclampsia, we detected a significant locus on 2p13 with a lod score of 4.70 (single point P < 3.49 x 10(-6)). This is the first reported locus for pre-eclampsia meeting the criteria for genome-wide significance.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1093/hmg/8.9.1799

Full metadata record

DC FieldValue Language
dc.contributor.authorArngrimsson, Ren
dc.contributor.authorSigurardottir, Sen
dc.contributor.authorFrigge, M Len
dc.contributor.authorBjarnad ttir, R Ien
dc.contributor.authorJonsson, Ten
dc.contributor.authorStefansson, Hen
dc.contributor.authorBaldursdottir, Aen
dc.contributor.authorEinarsdottir, A Sen
dc.contributor.authorPalsson, Ben
dc.contributor.authorSnorradottir, Sen
dc.contributor.authorLachmeijer, A Men
dc.contributor.authorNicolae, Den
dc.contributor.authorKong, Aen
dc.contributor.authorBragason, B Ten
dc.contributor.authorGulcher, J Ren
dc.contributor.authorGeirsson, R Ten
dc.contributor.authorStefansson, Ken
dc.date.accessioned2009-10-20T09:10:58Z-
dc.date.available2009-10-20T09:10:58Z-
dc.date.issued1999-09-01-
dc.date.submitted2009-10-20-
dc.identifier.citationHum. Mol. Genet. 1999, 8(9):1799-805en
dc.identifier.issn0964-6906-
dc.identifier.pmid10441346-
dc.identifier.doi10.1093/hmg/8.9.1799-
dc.identifier.urihttp://hdl.handle.net/2336/84473-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPre-eclampsia is a common and serious disease and a major cause of maternal and infant mortality. Antenatal care systems world-wide screen for signs of the disease such as hypertension and proteinuria. Unlike most other human disorders it impacts two individuals, the mother and the child, both of whom can be severely affected. The pathophysiology of the disorder is incompletely understood, but familial clustering of the disease is apparent. Here we report the results of a genome-wide screen of Icelandic families representing 343 affected women. Including those patients with non-proteinuric pre-eclampsia (gestational hypertension), proteinuric pre-eclampsia and eclampsia, we detected a significant locus on 2p13 with a lod score of 4.70 (single point P < 3.49 x 10(-6)). This is the first reported locus for pre-eclampsia meeting the criteria for genome-wide significance.en
dc.language.isoenen
dc.publisherIRL Press at Oxford University Pressen
dc.relation.urlhttp://dx.doi.org/10.1093/hmg/8.9.1799en
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 2en
dc.subject.meshFemaleen
dc.subject.meshGenetic Markersen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenome, Humanen
dc.subject.meshGenotypeen
dc.subject.meshHaplotypesen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLinkage (Genetics)en
dc.subject.meshLod Scoreen
dc.subject.meshPedigreeen
dc.subject.meshPre-Eclampsiaen
dc.subject.meshPregnancyen
dc.titleA genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13en
dc.typeArticleen
dc.identifier.eissn1460-2083-
dc.contributor.departmentMedical Genetics Unit, Faculty of Medicine, University of Iceland, Medical School Building, Vatnsmrarvegur, 101 Reykjavík, Iceland.en
dc.identifier.journalHuman molecular geneticsen

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