Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility

2.50
Hdl Handle:
http://hdl.handle.net/2336/84474
Title:
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
Authors:
Gudmundsson, Julius; Sulem, Patrick; Gudbjartsson, Daniel F; Blondal, Thorarinn; Gylfason, Arnaldur; Agnarsson, Bjarni A; Benediktsdottir, Kristrun R; Magnusdottir, Droplaug N; Orlygsdottir, Gudbjorg; Jakobsdottir, Margret; Stacey, Simon N; Sigurdsson, Asgeir; Wahlfors, Tiina; Tammela, Teuvo; Breyer, Joan P; McReynolds, Kate M; Bradley, Kevin M; Saez, Berta; Godino, Javier; Navarrete, Sebastian; Fuertes, Fernando; Murillo, Laura; Polo, Eduardo; Aben, Katja K; van Oort, Inge M; Suarez, Brian K; Helfand, Brian T; Kan, Donghui; Zanon, Carlo; Frigge, Michael L; Kristjansson, Kristleifur; Gulcher, Jeffrey R; Einarsson, Gudmundur V; Jonsson, Eirikur; Catalona, William J; Mayordomo, Jose I; Kiemeney, Lambertus A; Smith, Jeffrey R; Schleutker, Johanna; Barkardottir, Rosa B; Kong, Augustine; Thorsteinsdottir, Unnur; Rafnar, Thorunn; Stefansson, Kari
Citation:
Nat. Genet. 2009, 41(10):1122-6
Issue Date:
1-Oct-2009
Abstract:
We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.448; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562712/; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562712/
Rights:
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DC FieldValue Language
dc.contributor.authorGudmundsson, Juliusen
dc.contributor.authorSulem, Patricken
dc.contributor.authorGudbjartsson, Daniel Fen
dc.contributor.authorBlondal, Thorarinnen
dc.contributor.authorGylfason, Arnalduren
dc.contributor.authorAgnarsson, Bjarni Aen
dc.contributor.authorBenediktsdottir, Kristrun Ren
dc.contributor.authorMagnusdottir, Droplaug Nen
dc.contributor.authorOrlygsdottir, Gudbjorgen
dc.contributor.authorJakobsdottir, Margreten
dc.contributor.authorStacey, Simon Nen
dc.contributor.authorSigurdsson, Asgeiren
dc.contributor.authorWahlfors, Tiinaen
dc.contributor.authorTammela, Teuvoen
dc.contributor.authorBreyer, Joan Pen
dc.contributor.authorMcReynolds, Kate Men
dc.contributor.authorBradley, Kevin Men
dc.contributor.authorSaez, Bertaen
dc.contributor.authorGodino, Javieren
dc.contributor.authorNavarrete, Sebastianen
dc.contributor.authorFuertes, Fernandoen
dc.contributor.authorMurillo, Lauraen
dc.contributor.authorPolo, Eduardoen
dc.contributor.authorAben, Katja Ken
dc.contributor.authorvan Oort, Inge Men
dc.contributor.authorSuarez, Brian Ken
dc.contributor.authorHelfand, Brian Ten
dc.contributor.authorKan, Donghuien
dc.contributor.authorZanon, Carloen
dc.contributor.authorFrigge, Michael Len
dc.contributor.authorKristjansson, Kristleifuren
dc.contributor.authorGulcher, Jeffrey Ren
dc.contributor.authorEinarsson, Gudmundur Ven
dc.contributor.authorJonsson, Eirikuren
dc.contributor.authorCatalona, William Jen
dc.contributor.authorMayordomo, Jose Ien
dc.contributor.authorKiemeney, Lambertus Aen
dc.contributor.authorSmith, Jeffrey Ren
dc.contributor.authorSchleutker, Johannaen
dc.contributor.authorBarkardottir, Rosa Ben
dc.contributor.authorKong, Augustineen
dc.contributor.authorThorsteinsdottir, Unnuren
dc.contributor.authorRafnar, Thorunnen
dc.contributor.authorStefansson, Karien
dc.date.accessioned2009-10-20T09:24:50Zen
dc.date.available2009-10-20T09:24:50Zen
dc.date.issued2009-10-01en
dc.date.submitted2009-10-20en
dc.identifier.citationNat. Genet. 2009, 41(10):1122-6en
dc.identifier.issn1546-1718en
dc.identifier.pmid19767754en
dc.identifier.doi10.1038/ng.448en
dc.identifier.urihttp://hdl.handle.net/2336/84474en
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.en
dc.description.sponsorshipinfo:eu-repo/grantAgreement/EC/FP7/218071 European Union 202059 V Foundation US Department of Veterans Affairs Academy of Finland Sigrid Juselius Foundation Pirkanmaa Hospital District, Tampere University Hospitalen
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/218071en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.448en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562712/en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562712/en
dc.rightsopenAccessen
dc.subject.meshDNAen
dc.subject.meshDNA Replicationen
dc.subject.meshDisease Susceptibilityen
dc.subject.meshEuropean Continental Ancestry Groupen
dc.subject.meshGenome, Humanen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshProstatic Neoplasmsen
dc.subject.meshRisk Factorsen
dc.titleGenome-wide association and replication studies identify four variants associated with prostate cancer susceptibilityen
dc.typeArticleen
dc.contributor.departmentdeCODE Genetics, Reykjavik, Iceland.en
dc.identifier.journalNature geneticsen

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