Familial predisposition to monoclonal gammopathy of unknown significance, Waldenström's macroglobulinemia, and multiple myeloma

2.50
Hdl Handle:
http://hdl.handle.net/2336/84475
Title:
Familial predisposition to monoclonal gammopathy of unknown significance, Waldenström's macroglobulinemia, and multiple myeloma
Authors:
Ogmundsdottir, Helga M; Einarsdottir, Helga K; Steingrimsdottir, Hlif; Haraldsdottir, Vilhelmina
Citation:
Clin Lymphoma Myeloma. 2009, 9(1):27-9
Issue Date:
1-Mar-2009
Abstract:
The medical literature contains reports of around 130 families with two or more cases of MM, MGUS, or WM. An Icelandic family with multiple cases of MGUS, WM, and lymphoma was first described in 1978. In vitro testing of peripheral blood lymphocytes revealed increased production of immunoglobulins in response to poke-weed mitogen in 10 out of 35 family members, referred to as hyperresponders (HR). Enhanced B-cell survival after stimulation was associated with prolonged expression of Bcl-2. A population-based cancer registry study of 218 MM patients identified 7 additional families. Nine new cases of monoclonal gammopathy were detected by the screening of 350 family members. Further testing confirmed previously identified HR in the originally described family as well as detecting new cases. Only two HR were found in the recently identified families. The long-term aim is to identify the genetic background(s) and biology predisposing to the emergence of a persistent clone of immunoglobulin-producing cells.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.3816/CLM.2009.n.005

Full metadata record

DC FieldValue Language
dc.contributor.authorOgmundsdottir, Helga Men
dc.contributor.authorEinarsdottir, Helga Ken
dc.contributor.authorSteingrimsdottir, Hlifen
dc.contributor.authorHaraldsdottir, Vilhelminaen
dc.date.accessioned2009-10-20T09:38:07Z-
dc.date.available2009-10-20T09:38:07Z-
dc.date.issued2009-03-01-
dc.date.submitted2009-10-20-
dc.identifier.citationClin Lymphoma Myeloma. 2009, 9(1):27-9en
dc.identifier.issn1557-9190-
dc.identifier.pmid19362965-
dc.identifier.doi10.3816/CLM.2009.n.005-
dc.identifier.urihttp://hdl.handle.net/2336/84475-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe medical literature contains reports of around 130 families with two or more cases of MM, MGUS, or WM. An Icelandic family with multiple cases of MGUS, WM, and lymphoma was first described in 1978. In vitro testing of peripheral blood lymphocytes revealed increased production of immunoglobulins in response to poke-weed mitogen in 10 out of 35 family members, referred to as hyperresponders (HR). Enhanced B-cell survival after stimulation was associated with prolonged expression of Bcl-2. A population-based cancer registry study of 218 MM patients identified 7 additional families. Nine new cases of monoclonal gammopathy were detected by the screening of 350 family members. Further testing confirmed previously identified HR in the originally described family as well as detecting new cases. Only two HR were found in the recently identified families. The long-term aim is to identify the genetic background(s) and biology predisposing to the emergence of a persistent clone of immunoglobulin-producing cells.en
dc.language.isoenen
dc.publisherCancer Information Groupen
dc.relation.urlhttp://dx.doi.org/10.3816/CLM.2009.n.005en
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMultiple Myelomaen
dc.subject.meshParaproteinemiasen
dc.subject.meshWaldenstrom Macroglobulinemiaen
dc.titleFamilial predisposition to monoclonal gammopathy of unknown significance, Waldenström's macroglobulinemia, and multiple myelomaen
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, University of Iceland, Reykjavik, Iceland. helgaogm@hi.isen
dc.identifier.journalClinical lymphoma & myelomaen

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