2.50
Hdl Handle:
http://hdl.handle.net/2336/84794
Title:
Variant in the sequence of the LINGO1 gene confers risk of essential tremor
Authors:
Stefansson, Hreinn; Steinberg, Stacy; Petursson, Hjorvar; Gustafsson, Omar; Gudjonsdottir, Iris H; Jonsdottir, Gudrun A; Palsson, Stefan T; Jonsson, Thorlakur; Saemundsdottir, Jona; Bjornsdottir, Gyda; Böttcher, Yvonne; Thorlacius, Theodora; Haubenberger, Dietrich; Zimprich, Alexander; Auff, Eduard; Hotzy, Christoph; Testa, Claudia M; Miyatake, Lisa A; Rosen, Ami R; Kristleifsson, Kristleifur; Rye, David; Asmus, Friedrich; Schöls, Ludger; Dichgans, Martin; Jakobsson, Finnbogi; Benedikz, John; Thorsteinsdottir, Unnur; Gulcher, Jeffrey; Kong, Augustine; Stefansson, Kari
Citation:
Nat. Genet. 2009, 41(3):277-9
Issue Date:
1-Mar-2009
Abstract:
We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.299

Full metadata record

DC FieldValue Language
dc.contributor.authorStefansson, Hreinnen
dc.contributor.authorSteinberg, Stacyen
dc.contributor.authorPetursson, Hjorvaren
dc.contributor.authorGustafsson, Omaren
dc.contributor.authorGudjonsdottir, Iris Hen
dc.contributor.authorJonsdottir, Gudrun Aen
dc.contributor.authorPalsson, Stefan Ten
dc.contributor.authorJonsson, Thorlakuren
dc.contributor.authorSaemundsdottir, Jonaen
dc.contributor.authorBjornsdottir, Gydaen
dc.contributor.authorBöttcher, Yvonneen
dc.contributor.authorThorlacius, Theodoraen
dc.contributor.authorHaubenberger, Dietrichen
dc.contributor.authorZimprich, Alexanderen
dc.contributor.authorAuff, Eduarden
dc.contributor.authorHotzy, Christophen
dc.contributor.authorTesta, Claudia Men
dc.contributor.authorMiyatake, Lisa Aen
dc.contributor.authorRosen, Ami Ren
dc.contributor.authorKristleifsson, Kristleifuren
dc.contributor.authorRye, Daviden
dc.contributor.authorAsmus, Friedrichen
dc.contributor.authorSchöls, Ludgeren
dc.contributor.authorDichgans, Martinen
dc.contributor.authorJakobsson, Finnbogien
dc.contributor.authorBenedikz, Johnen
dc.contributor.authorThorsteinsdottir, Unnuren
dc.contributor.authorGulcher, Jeffreyen
dc.contributor.authorKong, Augustineen
dc.contributor.authorStefansson, Karien
dc.date.accessioned2009-10-23T13:32:03Z-
dc.date.available2009-10-23T13:32:03Z-
dc.date.issued2009-03-01-
dc.date.submitted2009-10-22-
dc.identifier.citationNat. Genet. 2009, 41(3):277-9en
dc.identifier.issn1546-1718-
dc.identifier.pmid19182806-
dc.identifier.doi10.1038/ng.299-
dc.identifier.urihttp://hdl.handle.net/2336/84794-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]en
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1038/ng.299en
dc.subject.meshAnimalsen
dc.subject.meshAustriaen
dc.subject.meshEssential Tremoren
dc.subject.meshGene Frequencyen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenetics, Populationen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshGermanyen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLinkage Disequilibriumen
dc.subject.meshMembrane Proteinsen
dc.subject.meshMiceen
dc.subject.meshMice, Knockouten
dc.subject.meshNerve Tissue Proteinsen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshRisk Factorsen
dc.subject.meshUnited Statesen
dc.titleVariant in the sequence of the LINGO1 gene confers risk of essential tremoren
dc.typeArticleen
dc.contributor.departmentdeCODE genetics, Sturlugata 8, IS-101 Reykjavík, Iceland.en
dc.identifier.journalNature geneticsen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.