A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

2.50
Hdl Handle:
http://hdl.handle.net/2336/84801
Title:
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
Authors:
Gudbjartsson, Daniel F; Holm, Hilma; Gretarsdottir, Solveig; Thorleifsson, Gudmar; Walters, G Bragi; Thorgeirsson, Gudmundur; Gulcher, Jeffrey; Mathiesen, Ellisiv B; Njølstad, Inger; Nyrnes, Audhild; Wilsgaard, Tom; Hald, Erin M; Hveem, Kristian; Stoltenberg, Camilla; Kucera, Gayle; Stubblefield, Tanya; Carter, Shannon; Roden, Dan; Ng, Maggie C Y; Baum, Larry; So, Wing Yee; Wong, Ka Sing; Chan, Juliana C N; Gieger, Christian; Wichmann, H-Erich; Gschwendtner, Andreas; Dichgans, Martin; Kuhlenbäumer, Gregor; Berger, Klaus; Ringelstein, E Bernd; Bevan, Steve; Markus, Hugh S; Kostulas, Konstantinos; Hillert, Jan; Sveinbjörnsdóttir, Sigurlaug; Valdimarsson, Einar M; Løchen, Maja-Lisa; Ma, Ronald C W; Darbar, Dawood; Kong, Augustine; Arnar, David O; Thorsteinsdottir, Unnur; Stefansson, Kari
Citation:
Nat. Genet. 2009, 41(8):876-8
Issue Date:
1-Aug-2009
Abstract:
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.
Description:
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open
Additional Links:
http://dx.doi.org/10.1038/ng.417

Full metadata record

DC FieldValue Language
dc.contributor.authorGudbjartsson, Daniel Fen
dc.contributor.authorHolm, Hilmaen
dc.contributor.authorGretarsdottir, Solveigen
dc.contributor.authorThorleifsson, Gudmaren
dc.contributor.authorWalters, G Bragien
dc.contributor.authorThorgeirsson, Gudmunduren
dc.contributor.authorGulcher, Jeffreyen
dc.contributor.authorMathiesen, Ellisiv Ben
dc.contributor.authorNjølstad, Ingeren
dc.contributor.authorNyrnes, Audhilden
dc.contributor.authorWilsgaard, Tomen
dc.contributor.authorHald, Erin Men
dc.contributor.authorHveem, Kristianen
dc.contributor.authorStoltenberg, Camillaen
dc.contributor.authorKucera, Gayleen
dc.contributor.authorStubblefield, Tanyaen
dc.contributor.authorCarter, Shannonen
dc.contributor.authorRoden, Danen
dc.contributor.authorNg, Maggie C Yen
dc.contributor.authorBaum, Larryen
dc.contributor.authorSo, Wing Yeeen
dc.contributor.authorWong, Ka Singen
dc.contributor.authorChan, Juliana C Nen
dc.contributor.authorGieger, Christianen
dc.contributor.authorWichmann, H-Erichen
dc.contributor.authorGschwendtner, Andreasen
dc.contributor.authorDichgans, Martinen
dc.contributor.authorKuhlenbäumer, Gregoren
dc.contributor.authorBerger, Klausen
dc.contributor.authorRingelstein, E Bernden
dc.contributor.authorBevan, Steveen
dc.contributor.authorMarkus, Hugh Sen
dc.contributor.authorKostulas, Konstantinosen
dc.contributor.authorHillert, Janen
dc.contributor.authorSveinbjörnsdóttir, Sigurlaugen
dc.contributor.authorValdimarsson, Einar Men
dc.contributor.authorLøchen, Maja-Lisaen
dc.contributor.authorMa, Ronald C Wen
dc.contributor.authorDarbar, Dawooden
dc.contributor.authorKong, Augustineen
dc.contributor.authorArnar, David Oen
dc.contributor.authorThorsteinsdottir, Unnuren
dc.contributor.authorStefansson, Karien
dc.date.accessioned2009-10-23T14:23:48Z-
dc.date.available2009-10-23T14:23:48Z-
dc.date.issued2009-08-01-
dc.date.submitted2009-10-23-
dc.identifier.citationNat. Genet. 2009, 41(8):876-8en
dc.identifier.issn1546-1718-
dc.identifier.pmid19597491-
dc.identifier.doi10.1038/ng.417-
dc.identifier.urihttp://hdl.handle.net/2336/84801-
dc.descriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Openen
dc.description.abstractWe expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.en
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1038/ng.417en
dc.subject.meshAtrial Fibrillationen
dc.subject.meshBase Sequenceen
dc.subject.meshBrain Ischemiaen
dc.subject.meshChromosomes, Human, Pair 16en
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHomeodomain Proteinsen
dc.subject.meshHumansen
dc.subject.meshMutationen
dc.subject.meshStrokeen
dc.titleA sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.en
dc.typeArticleen
dc.contributor.departmentDeCode Genetics, Reykjavik, Iceland. daniel.gudbjartsson@decode.isen
dc.identifier.journalNature geneticsen

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