Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche

2.50
Hdl Handle:
http://hdl.handle.net/2336/84839
Title:
Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche
Authors:
Sulem, P; Gudbjartsson, D F; Rafnar, T; Holm, H; Olafsdottir, E J; Olafsdottir, G H; Jonsson, T; Alexandersen, P; Feenstra, B; Boyd, H A; Aben, K K; Verbeek, A L; Roeleveld, N; Jonasdottir, A; Styrkarsdottir, U; Steinthorsdottir, V; Karason, A; Stacey, S N; Gudmundsson, J; Jakobsdottir, M; Thorleifsson, G; Hardarson, G; Gulcher, J; Kong, A; Kiemeney, LA; Melbye, M; Christiansen, C; Tryggvadottir, L; Thorsteinsdottir, U; Stefansson, K
Citation:
Nat. Genet. 2009, 41(6):734-8
Issue Date:
17-May-2009
Abstract:
Earlier menarche correlates with shorter adult height and higher childhood body fat. We conducted a genome-wide association study of age at menarche (AAM) on 15,297 Icelandic women. Combined analysis with replication sets from Iceland, Denmark and the Netherlands (N = 10,040) yielded a significant association between rs314280[T] on 6q21, near the LIN28B gene, and AAM (effect = 1.2 months later per allele; P = 1.8 x 10(-14)). A second SNP within the same linkage disequilibrium (LD) block, rs314277, splits rs314280[T] into two haplotypes with different effects (0.9 months and 1.9 months per allele). These variants have been associated with greater adult height. The association with adult height did not account for the association with AAM or vice versa. Other variants, previously associated with height, did not associate significantly with AAM. Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.383

Full metadata record

DC FieldValue Language
dc.contributor.authorSulem, Pen
dc.contributor.authorGudbjartsson, D Fen
dc.contributor.authorRafnar, Ten
dc.contributor.authorHolm, Hen
dc.contributor.authorOlafsdottir, E Jen
dc.contributor.authorOlafsdottir, G Hen
dc.contributor.authorJonsson, Ten
dc.contributor.authorAlexandersen, Pen
dc.contributor.authorFeenstra, Ben
dc.contributor.authorBoyd, H Aen
dc.contributor.authorAben, K Ken
dc.contributor.authorVerbeek, A Len
dc.contributor.authorRoeleveld, Nen
dc.contributor.authorJonasdottir, Aen
dc.contributor.authorStyrkarsdottir, Uen
dc.contributor.authorSteinthorsdottir, Ven
dc.contributor.authorKarason, Aen
dc.contributor.authorStacey, S Nen
dc.contributor.authorGudmundsson, Jen
dc.contributor.authorJakobsdottir, Men
dc.contributor.authorThorleifsson, Gen
dc.contributor.authorHardarson, Gen
dc.contributor.authorGulcher, Jen
dc.contributor.authorKong, Aen
dc.contributor.authorKiemeney, LAen
dc.contributor.authorMelbye, Men
dc.contributor.authorChristiansen, Cen
dc.contributor.authorTryggvadottir, Len
dc.contributor.authorThorsteinsdottir, Uen
dc.contributor.authorStefansson, Ken
dc.date.accessioned2009-10-26T11:38:47Z-
dc.date.available2009-10-26T11:38:47Z-
dc.date.issued2009-05-17-
dc.date.submitted2009-10-26-
dc.identifier.citationNat. Genet. 2009, 41(6):734-8en
dc.identifier.issn1546-1718-
dc.identifier.pmid19448622-
dc.identifier.doi10.1038/ng.383-
dc.identifier.urihttp://hdl.handle.net/2336/84839-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractEarlier menarche correlates with shorter adult height and higher childhood body fat. We conducted a genome-wide association study of age at menarche (AAM) on 15,297 Icelandic women. Combined analysis with replication sets from Iceland, Denmark and the Netherlands (N = 10,040) yielded a significant association between rs314280[T] on 6q21, near the LIN28B gene, and AAM (effect = 1.2 months later per allele; P = 1.8 x 10(-14)). A second SNP within the same linkage disequilibrium (LD) block, rs314277, splits rs314280[T] into two haplotypes with different effects (0.9 months and 1.9 months per allele). These variants have been associated with greater adult height. The association with adult height did not account for the association with AAM or vice versa. Other variants, previously associated with height, did not associate significantly with AAM. Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM.en
dc.languageENG-
dc.language.ison/aen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.383en
dc.subject.meshPubMed in processen
dc.titleGenome-wide association study identifies sequence variants on 6q21 associated with age at menarchen/a
dc.typeArticleen
dc.contributor.department[1] deCODE Genetics, Reykjavik, Iceland. [2] These authors contributed equally to this work.en
dc.identifier.journalNature geneticsen

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