A strong heritability of psoriatic arthritis over four generations--the Reykjavik Psoriatic Arthritis Study

2.50
Hdl Handle:
http://hdl.handle.net/2336/84853
Title:
A strong heritability of psoriatic arthritis over four generations--the Reykjavik Psoriatic Arthritis Study
Authors:
Karason, A; Love, T J; Gudbjornsson, B
Citation:
Rheumatology (Oxford). 2009, 48(11):1424-8
Issue Date:
1-Nov-2009
Abstract:
OBJECTIVE: We have studied the prevalence of PsA in Reykjavik, Iceland, in a population-based cohort, and using the Icelandic genealogy database we have estimated the risk ratio (RR) spanning five generations. METHODS: The national identification numbers of all 220 living Icelanders in Reykjavik known to have PsA were linked with the genealogy database. RRs for developing PsA were estimated in first-degree relatives (FDRs) to fifth-degree relatives of PsA cases. The kinship coefficient (KC) for PsA was also calculated. The control populations were 1000 and 10,000 sets of matched Icelandic subjects for each proband, respectively. RESULTS: FDRs to fourth-degree relatives of patients with PsA had RRs of 39, 12, 3.6 and 2.3, respectively (all P-values < 0.0001), reflecting a strong genetic component, whereas the fifth-degree relatives had an RR of 1.2 (P = 0.236). KCs of 5.0, 3.4, 1.7, 1.3, 1.0, 0.8 and 0.7 were observed for the first seven excluded meioses (all P-values < 0.0001), confirming the familial risk. CONCLUSIONS: Patients with PsA in Reykjavik, Iceland, are significantly more related to each other than to randomly sampled control subjects. This is in agreement with previous reports, but the present study examines the inheritance in more distantly related individuals. These findings indicate that in addition to a strong and complex genetic component in PsA, there is an important environmental contribution.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1093/rheumatology/kep243

Full metadata record

DC FieldValue Language
dc.contributor.authorKarason, Aen
dc.contributor.authorLove, T Jen
dc.contributor.authorGudbjornsson, Ben
dc.date.accessioned2009-10-26T11:09:59Z-
dc.date.available2009-10-26T11:09:59Z-
dc.date.issued2009-11-01-
dc.date.submitted2009-10-26-
dc.identifier.citationRheumatology (Oxford). 2009, 48(11):1424-8en
dc.identifier.issn1462-0332-
dc.identifier.pmid19741010-
dc.identifier.doi10.1093/rheumatology/kep243-
dc.identifier.urihttp://hdl.handle.net/2336/84853-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: We have studied the prevalence of PsA in Reykjavik, Iceland, in a population-based cohort, and using the Icelandic genealogy database we have estimated the risk ratio (RR) spanning five generations. METHODS: The national identification numbers of all 220 living Icelanders in Reykjavik known to have PsA were linked with the genealogy database. RRs for developing PsA were estimated in first-degree relatives (FDRs) to fifth-degree relatives of PsA cases. The kinship coefficient (KC) for PsA was also calculated. The control populations were 1000 and 10,000 sets of matched Icelandic subjects for each proband, respectively. RESULTS: FDRs to fourth-degree relatives of patients with PsA had RRs of 39, 12, 3.6 and 2.3, respectively (all P-values < 0.0001), reflecting a strong genetic component, whereas the fifth-degree relatives had an RR of 1.2 (P = 0.236). KCs of 5.0, 3.4, 1.7, 1.3, 1.0, 0.8 and 0.7 were observed for the first seven excluded meioses (all P-values < 0.0001), confirming the familial risk. CONCLUSIONS: Patients with PsA in Reykjavik, Iceland, are significantly more related to each other than to randomly sampled control subjects. This is in agreement with previous reports, but the present study examines the inheritance in more distantly related individuals. These findings indicate that in addition to a strong and complex genetic component in PsA, there is an important environmental contribution.en
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1093/rheumatology/kep243en
dc.subject.meshArthritis, Psoriaticen
dc.subject.meshGeneticsen
dc.titleA strong heritability of psoriatic arthritis over four generations--the Reykjavik Psoriatic Arthritis Studyen
dc.typeArticleen
dc.contributor.departmentdeCODE Genetics, Reykjavik, Iceland.en
dc.identifier.journalRheumatology (Oxford, England)en

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