2.50
Hdl Handle:
http://hdl.handle.net/2336/84874
Title:
Many sequence variants affecting diversity of adult human height
Authors:
Gudbjartsson, Daniel F; Walters, G Bragi; Thorleifsson, Gudmar; Stefansson, Hreinn; Halldorsson, Bjarni V; Zusmanovich, Pasha; Sulem, Patrick; Thorlacius, Steinunn; Gylfason, Arnaldur; Steinberg, Stacy; Helgadottir, Anna; Ingason, Andres; Steinthorsdottir, Valgerdur; Olafsdottir, Elinborg J; Olafsdottir, Gudridur H; Jonsson, Thorvaldur; Borch-Johnsen, Knut; Hansen, Torben; Andersen, Gitte; Jorgensen, Torben; Pedersen, Oluf; Aben, Katja K; Witjes, J Alfred; Swinkels, Dorine W; den Heijer, Martin; Franke, Barbara; Verbeek, Andre L M; Becker, Diane M; Yanek, Lisa R; Becker, Lewis C; Tryggvadottir, Laufey; Rafnar, Thorunn; Gulcher, Jeffrey; Kiemeney, Lambertus A; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
Citation:
Nat. Genet. 2008, 40(5):609-15
Issue Date:
1-May-2008
Abstract:
Adult human height is one of the classical complex human traits. We searched for sequence variants that affect height by scanning the genomes of 25,174 Icelanders, 2,876 Dutch, 1,770 European Americans and 1,148 African Americans. We then combined these results with previously published results from the Diabetes Genetics Initiative on 3,024 Scandinavians and tested a selected subset of SNPs in 5,517 Danes. We identified 27 regions of the genome with one or more sequence variants showing significant association with height. The estimated effects per allele of these variants ranged between 0.3 and 0.6 cm and, taken together, they explain around 3.7% of the population variation in height. The genes neighboring the identified loci cluster in biological processes related to skeletal development and mitosis. Association to three previously reported loci are replicated in our analyses, and the strongest association was with SNPs in the ZBTB38 gene.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.122

Full metadata record

DC FieldValue Language
dc.contributor.authorGudbjartsson, Daniel Fen
dc.contributor.authorWalters, G Bragien
dc.contributor.authorThorleifsson, Gudmaren
dc.contributor.authorStefansson, Hreinnen
dc.contributor.authorHalldorsson, Bjarni Ven
dc.contributor.authorZusmanovich, Pashaen
dc.contributor.authorSulem, Patricken
dc.contributor.authorThorlacius, Steinunnen
dc.contributor.authorGylfason, Arnalduren
dc.contributor.authorSteinberg, Stacyen
dc.contributor.authorHelgadottir, Annaen
dc.contributor.authorIngason, Andresen
dc.contributor.authorSteinthorsdottir, Valgerduren
dc.contributor.authorOlafsdottir, Elinborg Jen
dc.contributor.authorOlafsdottir, Gudridur Hen
dc.contributor.authorJonsson, Thorvalduren
dc.contributor.authorBorch-Johnsen, Knuten
dc.contributor.authorHansen, Torbenen
dc.contributor.authorAndersen, Gitteen
dc.contributor.authorJorgensen, Torbenen
dc.contributor.authorPedersen, Olufen
dc.contributor.authorAben, Katja Ken
dc.contributor.authorWitjes, J Alfreden
dc.contributor.authorSwinkels, Dorine Wen
dc.contributor.authorden Heijer, Martinen
dc.contributor.authorFranke, Barbaraen
dc.contributor.authorVerbeek, Andre L Men
dc.contributor.authorBecker, Diane Men
dc.contributor.authorYanek, Lisa Ren
dc.contributor.authorBecker, Lewis Cen
dc.contributor.authorTryggvadottir, Laufeyen
dc.contributor.authorRafnar, Thorunnen
dc.contributor.authorGulcher, Jeffreyen
dc.contributor.authorKiemeney, Lambertus Aen
dc.contributor.authorKong, Augustineen
dc.contributor.authorThorsteinsdottir, Unnuren
dc.contributor.authorStefansson, Karien
dc.date.accessioned2009-10-26T13:27:10Z-
dc.date.available2009-10-26T13:27:10Z-
dc.date.issued2008-05-01-
dc.date.submitted2009-10-26-
dc.identifier.citationNat. Genet. 2008, 40(5):609-15en
dc.identifier.issn1546-1718-
dc.identifier.pmid18391951-
dc.identifier.doi10.1038/ng.122-
dc.identifier.urihttp://hdl.handle.net/2336/84874-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractAdult human height is one of the classical complex human traits. We searched for sequence variants that affect height by scanning the genomes of 25,174 Icelanders, 2,876 Dutch, 1,770 European Americans and 1,148 African Americans. We then combined these results with previously published results from the Diabetes Genetics Initiative on 3,024 Scandinavians and tested a selected subset of SNPs in 5,517 Danes. We identified 27 regions of the genome with one or more sequence variants showing significant association with height. The estimated effects per allele of these variants ranged between 0.3 and 0.6 cm and, taken together, they explain around 3.7% of the population variation in height. The genes neighboring the identified loci cluster in biological processes related to skeletal development and mitosis. Association to three previously reported loci are replicated in our analyses, and the strongest association was with SNPs in the ZBTB38 gene.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.122en
dc.subject.meshAdulten
dc.subject.meshBody Heighten
dc.subject.meshBone Developmenten
dc.subject.meshDNA-Binding Proteinsen
dc.subject.meshFemaleen
dc.subject.meshGene Frequencyen
dc.subject.meshGenome, Humanen
dc.subject.meshHumansen
dc.subject.meshLinkage (Genetics)en
dc.subject.meshMaleen
dc.subject.meshMitosisen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshRepressor Proteinsen
dc.titleMany sequence variants affecting diversity of adult human heighten
dc.typeArticleen
dc.contributor.departmentdeCODE Genetics, 101 Reykjavik, Iceland. daniel.gudbjartsson@decode.isen
dc.identifier.journalNature geneticsen

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