2.50
Hdl Handle:
http://hdl.handle.net/2336/85056
Title:
Algengi hjartavöðvaþykknunar meðal karla á Íslandi
Authors:
Uggi Agnarsson; Þórður Harðarson; Jónas Hallgrímsson; Nikulás Sigfússon
Citation:
Læknablaðið 1992, 78(6):213-9
Issue Date:
1-Aug-1992
Abstract:
This study was designed to assess the prevalence of hypertrophic cardiomyopathy in a population sample of 3607 adult Icelandic men previously screened for cardiac risk factors. In this population 3155 men had a normal and 452 (group A) had an abnormal electrocardiogram. We used 2D-and M-mode echocardiography, reviewed and reexamined autopsy records of men from this cohort to identify men with hypertrophic cardiomyopathy. All men in group A as well as an echocardiographic control (group B) (n=128) with a normal original electrocardiogram were subjects of this study. The prevalence of hypertrophic cardiomyopathy among men with an abnormal electrocardiogram was 3.6%, and 0.8% among men with a normal electrocardiogram. During the 8 year interval between this study and the original screening (Reykjavik) study 59 of the 452 men in group A died, two of whom had hypertrophic cardiomyopathy diagnosed at autopsy. Among all men with a normal electrocardiogram there had been 130 deaths, two of whom had hypertrophic cardiomyopathy at autopsy. The annual mortality rate among men with hypertrophic cardiomyopathy in this population is 1.6% versus 0.5% among men with a normal (p<0.001) and 1.7% among men with an abnormal electrocardiogram (NS) in the absence of hypertrophic cardiomyopathy. Among the echo control group B we did not find any cases of hypertrophic cardiomyopathy. We estimated 41 case of hypertrophic cardiomyopathy among the 3607 men in the Reykjavik study and the overall calculated prevalence of hypertrophic cardiomyopathy was 1.1% with a 95% confidence interval of 0.3-3.2%. Men with hypertrophic cardiomyopathy more often reported angina (50%) and dyspnea (42%) than the other groups (p<0.05-0.001) where hypertrophic cardiomyopathy was not found, 25% were without symptoms and 45% had asymptomatic ventricular arrhythmias as determined by 24-hour ambulatory monitoring.; Hjartavöðvaþykknun (cardiomyopathia hypertrophica) einkennist af veggþykknun í vinstri slegli og sleglaskipt án víkkunar hjartahólfa og án þess að unnt sé að sýna fram á aðra sjúkdóma sem gætu leitt til þykknunar hjartaveggja (1). Rannsókn okkar var ætlað að meta algengi kvillans meðal fullorðinna karla í þýði sem valið var af handahófi. Ýmsar fyrri rannsóknir hafa bent til þess að 73-98% sjúklinga með hjartavöðvaþykknun hafi afbrigðilegt hjartarit (2-6). Hugmynd okkar var sú að hjartaritið væri næmt, en ósértækt greiningartæki hjartavöðvasjúkdóms í slembiúrtaki, þar sem margir einstaklingar eru án einkenna hjartasjúkdóms (7-9) og þannig væri hjartaritið gagnlegt til að velja einstaklinga til að rannsaka nánar og fá endanlega sjúkdómsgreiningu. Rannsókn Hjartavemdar hentar vel ef leita skal svara við spurningum af því tagi sem hér er lýst. Við ákváðum því að rannsaka hóp af körlum, sem höfðu reynst við fyrri rannsókn Hjartaverndar hafa afbrigðilegt hjartarit, en einnig var valinn samanburðarhópur sem hafði eðlilegt rit við fyrri skoðun Auk almennrar skoðunar og viðtals var ómskoðun á hjarta gerð hjá báðum hópunum.
Description:
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open
Additional Links:
http://www.laeknabladid.is

Full metadata record

DC FieldValue Language
dc.contributor.authorUggi Agnarssonen
dc.contributor.authorÞórður Harðarsonen
dc.contributor.authorJónas Hallgrímssonen
dc.contributor.authorNikulás Sigfússonen
dc.date.accessioned2009-10-30T13:14:27Z-
dc.date.available2009-10-30T13:14:27Z-
dc.date.issued1992-08-01-
dc.date.submitted2009-10-30-
dc.identifier.citationLæknablaðið 1992, 78(6):213-9en
dc.identifier.issn0023-7213-
dc.identifier.urihttp://hdl.handle.net/2336/85056-
dc.descriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Openen
dc.description.abstractThis study was designed to assess the prevalence of hypertrophic cardiomyopathy in a population sample of 3607 adult Icelandic men previously screened for cardiac risk factors. In this population 3155 men had a normal and 452 (group A) had an abnormal electrocardiogram. We used 2D-and M-mode echocardiography, reviewed and reexamined autopsy records of men from this cohort to identify men with hypertrophic cardiomyopathy. All men in group A as well as an echocardiographic control (group B) (n=128) with a normal original electrocardiogram were subjects of this study. The prevalence of hypertrophic cardiomyopathy among men with an abnormal electrocardiogram was 3.6%, and 0.8% among men with a normal electrocardiogram. During the 8 year interval between this study and the original screening (Reykjavik) study 59 of the 452 men in group A died, two of whom had hypertrophic cardiomyopathy diagnosed at autopsy. Among all men with a normal electrocardiogram there had been 130 deaths, two of whom had hypertrophic cardiomyopathy at autopsy. The annual mortality rate among men with hypertrophic cardiomyopathy in this population is 1.6% versus 0.5% among men with a normal (p<0.001) and 1.7% among men with an abnormal electrocardiogram (NS) in the absence of hypertrophic cardiomyopathy. Among the echo control group B we did not find any cases of hypertrophic cardiomyopathy. We estimated 41 case of hypertrophic cardiomyopathy among the 3607 men in the Reykjavik study and the overall calculated prevalence of hypertrophic cardiomyopathy was 1.1% with a 95% confidence interval of 0.3-3.2%. Men with hypertrophic cardiomyopathy more often reported angina (50%) and dyspnea (42%) than the other groups (p<0.05-0.001) where hypertrophic cardiomyopathy was not found, 25% were without symptoms and 45% had asymptomatic ventricular arrhythmias as determined by 24-hour ambulatory monitoring.en
dc.description.abstractHjartavöðvaþykknun (cardiomyopathia hypertrophica) einkennist af veggþykknun í vinstri slegli og sleglaskipt án víkkunar hjartahólfa og án þess að unnt sé að sýna fram á aðra sjúkdóma sem gætu leitt til þykknunar hjartaveggja (1). Rannsókn okkar var ætlað að meta algengi kvillans meðal fullorðinna karla í þýði sem valið var af handahófi. Ýmsar fyrri rannsóknir hafa bent til þess að 73-98% sjúklinga með hjartavöðvaþykknun hafi afbrigðilegt hjartarit (2-6). Hugmynd okkar var sú að hjartaritið væri næmt, en ósértækt greiningartæki hjartavöðvasjúkdóms í slembiúrtaki, þar sem margir einstaklingar eru án einkenna hjartasjúkdóms (7-9) og þannig væri hjartaritið gagnlegt til að velja einstaklinga til að rannsaka nánar og fá endanlega sjúkdómsgreiningu. Rannsókn Hjartavemdar hentar vel ef leita skal svara við spurningum af því tagi sem hér er lýst. Við ákváðum því að rannsaka hóp af körlum, sem höfðu reynst við fyrri rannsókn Hjartaverndar hafa afbrigðilegt hjartarit, en einnig var valinn samanburðarhópur sem hafði eðlilegt rit við fyrri skoðun Auk almennrar skoðunar og viðtals var ómskoðun á hjarta gerð hjá báðum hópunum.en
dc.language.isoisen
dc.publisherLæknafélag Íslands, Læknafélag Reykjavíkuren
dc.relation.urlhttp://www.laeknabladid.isen
dc.subjectHjartasjúkdómaren
dc.subject.meshCardiomyopathy, Hypertrophicen
dc.subject.meshIceland/epidemiologyen
dc.subject.meshMaleen
dc.titleAlgengi hjartavöðvaþykknunar meðal karla á Íslandiis
dc.typeAnimationen
dc.identifier.journalLæknablaðiðen
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