Accumulation of coronary artery disease risk factors over three years: data from an international inception cohort.

2.50
Hdl Handle:
http://hdl.handle.net/2336/85224
Title:
Accumulation of coronary artery disease risk factors over three years: data from an international inception cohort.
Authors:
Urowitz, M B; Gladman, D; Ibañez, D; Fortin, P; Sanchez-Guerrero, J; Bae, S; Clarke, A; Bernatsky, S; Gordon, C; Hanly, J; Wallace, D; Isenberg, D; Ginzler, E; Merrill, J; Alarcón, G S; Steinsson, K; Petri, M; Dooley, M A; Bruce, I; Manzi, S; Khamashta, M; Ramsey-Goldman, R; Zoma, A; Sturfelt, G; Nived, O; Maddison, P; Font, J; van Vollenhoven, R; Aranow, C; Kalunian, K; Stoll, T
Citation:
Arthritis Rheum. 2008, 59(2):176-80
Issue Date:
15-Feb-2008
Abstract:
OBJECTIVE: To examine the accumulation of risk factors over 3 years in a multicenter, international inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: The Systemic Lupus International Collaborating Clinics registry for atherosclerosis comprises 27 centers from 11 countries. An inception cohort of 935 patients with SLE was assembled, according to a standardized protocol, from 2000 to 2006 to study risk factors for atherosclerosis. Both classic and other coronary artery disease (CAD) risk factors were collected at entry and through 3 years of followup. Therapy was documented over the 3 years. The Framingham 10-year risk factor profile was calculated for each patient at year 1 and year 3. RESULTS: A total of 278 patients from the inception cohort were followed for 3 years and constituted the population for this study. At enrollment a substantial number of patients already demonstrated several risk factors for CAD, both classic and other. All risk factors increased from enrollment over the 3 years of followup. Treatment of hypertension and hypercholesterolemia also increased over 3 years, but less so for hypercholesterolemia. The Framingham 10-year CAD risk profile was higher in men than in women both at entry and at 3 years, and remained unchanged over the 3 years. Corticosteroid use increased only slightly over 3 years, but use of antimalarials and immunosuppressive agents increased to a greater extent. CONCLUSION: Patients with SLE should be monitored for CAD risk factors from the time of diagnosis and appropriate treatment should be instituted early.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1002/art.23353

Full metadata record

DC FieldValue Language
dc.contributor.authorUrowitz, M Ben
dc.contributor.authorGladman, Den
dc.contributor.authorIbañez, Den
dc.contributor.authorFortin, Pen
dc.contributor.authorSanchez-Guerrero, Jen
dc.contributor.authorBae, Sen
dc.contributor.authorClarke, Aen
dc.contributor.authorBernatsky, Sen
dc.contributor.authorGordon, Cen
dc.contributor.authorHanly, Jen
dc.contributor.authorWallace, Den
dc.contributor.authorIsenberg, Den
dc.contributor.authorGinzler, Een
dc.contributor.authorMerrill, Jen
dc.contributor.authorAlarcón, G Sen
dc.contributor.authorSteinsson, Ken
dc.contributor.authorPetri, Men
dc.contributor.authorDooley, M Aen
dc.contributor.authorBruce, Ien
dc.contributor.authorManzi, Sen
dc.contributor.authorKhamashta, Men
dc.contributor.authorRamsey-Goldman, Ren
dc.contributor.authorZoma, Aen
dc.contributor.authorSturfelt, Gen
dc.contributor.authorNived, Oen
dc.contributor.authorMaddison, Pen
dc.contributor.authorFont, Jen
dc.contributor.authorvan Vollenhoven, Ren
dc.contributor.authorAranow, Cen
dc.contributor.authorKalunian, Ken
dc.contributor.authorStoll, Ten
dc.date.accessioned2009-11-03T13:43:49Z-
dc.date.available2009-11-03T13:43:49Z-
dc.date.issued2008-02-15-
dc.date.submitted2009-11-03-
dc.identifier.citationArthritis Rheum. 2008, 59(2):176-80en
dc.identifier.issn0004-3591-
dc.identifier.pmid18240193-
dc.identifier.doi10.1002/art.23353-
dc.identifier.urihttp://hdl.handle.net/2336/85224-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To examine the accumulation of risk factors over 3 years in a multicenter, international inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: The Systemic Lupus International Collaborating Clinics registry for atherosclerosis comprises 27 centers from 11 countries. An inception cohort of 935 patients with SLE was assembled, according to a standardized protocol, from 2000 to 2006 to study risk factors for atherosclerosis. Both classic and other coronary artery disease (CAD) risk factors were collected at entry and through 3 years of followup. Therapy was documented over the 3 years. The Framingham 10-year risk factor profile was calculated for each patient at year 1 and year 3. RESULTS: A total of 278 patients from the inception cohort were followed for 3 years and constituted the population for this study. At enrollment a substantial number of patients already demonstrated several risk factors for CAD, both classic and other. All risk factors increased from enrollment over the 3 years of followup. Treatment of hypertension and hypercholesterolemia also increased over 3 years, but less so for hypercholesterolemia. The Framingham 10-year CAD risk profile was higher in men than in women both at entry and at 3 years, and remained unchanged over the 3 years. Corticosteroid use increased only slightly over 3 years, but use of antimalarials and immunosuppressive agents increased to a greater extent. CONCLUSION: Patients with SLE should be monitored for CAD risk factors from the time of diagnosis and appropriate treatment should be instituted early.en
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1002/art.23353en
dc.subject.meshAdrenal Cortex Hormonesen
dc.subject.meshAdulten
dc.subject.meshAsiaen
dc.subject.meshCohort Studiesen
dc.subject.meshCoronary Artery Diseaseen
dc.subject.meshEuropeen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHumansen
dc.subject.meshHypercholesterolemiaen
dc.subject.meshHypertensionen
dc.subject.meshLupus Erythematosus, Systemicen
dc.subject.meshMaleen
dc.subject.meshNorth Americaen
dc.subject.meshRegistriesen
dc.subject.meshRisk Assessmenten
dc.subject.meshRisk Factorsen
dc.titleAccumulation of coronary artery disease risk factors over three years: data from an international inception cohort.en
dc.typeArticleen
dc.contributor.departmentCentre for Prognosis Studies, Toronto Western Hospital, Toronto, Ontario, Canada. m.urowitz@toronto.caen
dc.identifier.journalArthritis and rheumatismen

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