5.00
Hdl Handle:
http://hdl.handle.net/2336/86463
Title:
Liver cirrhosis in Iceland and Sweden: incidence, aetiology and outcomes
Authors:
Gunnarsdottir, S A; Olsson, R; Olafsson, S; Cariglia, N; Westin, J; Thjodleifsson, B; Bjornsson, E
Citation:
Scand. J. Gastroenterol. 2009, 44(8):984-93
Issue Date:
1-Aug-2009
Abstract:
Objective . The objectives of this study were to investigate the incidence, aetiology and mortality of liver cirrhosis in Iceland and in Gothenburg in Sweden. Further objectives were prognosis in relation to different aetiologies and to evaluate the relationship between alcohol consumption in these countries and the incidence of alcoholic cirrhosis in recent decades. The incidence and mortality of liver cirrhosis in Iceland has been reported to be the lowest in the Western world. There are very few data on aetiology, incidence and prognosis among cirrhotics in Sweden. Material and methods . All patients diagnosed with liver cirrhosis in Gothenburg (600,000 inhabitants) and Iceland (300,000 inhabitants) during the period 1994-2003 were included. Results . A total of 918 patients in Gothenburg and 98 in Iceland were identified. The annual incidence in Gothenburg was 15.3+/-2.4/100,000 compared to 3.3+/-1.2/100,000 in Iceland (p<0.0001). In Gothenburg, 69% were male and in Iceland 52% (p<0.001). In Gothenburg, 50% of the patients had alcoholic cirrhosis compared to 29% in Iceland (p<0.0001). In Gothenburg, the patients had a higher Child-Pugh score (9.0) (SD 2.5) compared to Iceland (7.3) (SD 2.7) (p<0.0001). There was no difference in survival between patients with alcoholic liver disease and those with other aetiologies. Conclusions . The incidence of liver cirrhosis is low in Iceland, i.e. 24% of the incidence in Gothenburg, due to the lower incidence of alcoholic and hepatitis C cirrhosis in Iceland. No increasing trends in the incidence of cirrhosis in these two countries were observed during the study period.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1080/00365520902912571

Full metadata record

DC FieldValue Language
dc.contributor.authorGunnarsdottir, S Aen
dc.contributor.authorOlsson, Ren
dc.contributor.authorOlafsson, Sen
dc.contributor.authorCariglia, Nen
dc.contributor.authorWestin, Jen
dc.contributor.authorThjodleifsson, Ben
dc.contributor.authorBjornsson, Een
dc.date.accessioned2009-11-19T12:56:23Z-
dc.date.available2009-11-19T12:56:23Z-
dc.date.issued2009-08-01-
dc.date.submitted2009-11-19-
dc.identifier.citationScand. J. Gastroenterol. 2009, 44(8):984-93en
dc.identifier.issn1502-7708-
dc.identifier.pmid19437344-
dc.identifier.doi10.1080/00365520902912571-
dc.identifier.urihttp://hdl.handle.net/2336/86463-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractObjective . The objectives of this study were to investigate the incidence, aetiology and mortality of liver cirrhosis in Iceland and in Gothenburg in Sweden. Further objectives were prognosis in relation to different aetiologies and to evaluate the relationship between alcohol consumption in these countries and the incidence of alcoholic cirrhosis in recent decades. The incidence and mortality of liver cirrhosis in Iceland has been reported to be the lowest in the Western world. There are very few data on aetiology, incidence and prognosis among cirrhotics in Sweden. Material and methods . All patients diagnosed with liver cirrhosis in Gothenburg (600,000 inhabitants) and Iceland (300,000 inhabitants) during the period 1994-2003 were included. Results . A total of 918 patients in Gothenburg and 98 in Iceland were identified. The annual incidence in Gothenburg was 15.3+/-2.4/100,000 compared to 3.3+/-1.2/100,000 in Iceland (p<0.0001). In Gothenburg, 69% were male and in Iceland 52% (p<0.001). In Gothenburg, 50% of the patients had alcoholic cirrhosis compared to 29% in Iceland (p<0.0001). In Gothenburg, the patients had a higher Child-Pugh score (9.0) (SD 2.5) compared to Iceland (7.3) (SD 2.7) (p<0.0001). There was no difference in survival between patients with alcoholic liver disease and those with other aetiologies. Conclusions . The incidence of liver cirrhosis is low in Iceland, i.e. 24% of the incidence in Gothenburg, due to the lower incidence of alcoholic and hepatitis C cirrhosis in Iceland. No increasing trends in the incidence of cirrhosis in these two countries were observed during the study period.en
dc.languageENG-
dc.language.ison/aen
dc.publisherInforma Healthcareen
dc.relation.urlhttp://dx.doi.org/10.1080/00365520902912571en
dc.subject.meshLiver Cirrhosis, Alcoholicen
dc.subject.meshLiver Cirrhosisen
dc.subject.meshMortalityen
dc.titleLiver cirrhosis in Iceland and Sweden: incidence, aetiology and outcomesn/a
dc.typeArticleen
dc.contributor.departmentDepartment of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg, Sweden.en
dc.identifier.journalScandinavian journal of gastroenterologyen

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