Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients

2.50
Hdl Handle:
http://hdl.handle.net/2336/86554
Title:
Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients
Authors:
Thomsen, N. O. B; Englund, E.; Thrainsdottir, S; Rosén, I; Dahlin, L. B
Citation:
Diabet Med. 2009, 26(11):1120-6
Issue Date:
1-Nov-2009
Abstract:
Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies were obtained in conjunction with surgical carpal tunnel release. Biopsies were immunostained with anti-protein gene product (PGP) 9.5. The IENFD was quantified using manual counting by light microscopy. Results We could not demonstrate significant differences in IENFD between diabetic or non-diabetic patients. Additionally, no differences were found between patients with Type 1 and Type 2 diabetes or in diabetic patients with and without neurophysiologic signs of mild peripheral neuropathy. However, the IENFD was significantly higher in hairy skin compared with glabrous skin. Furthermore, the IENFD was significantly higher in females than in males and correlated with age, but not with duration of diabetes or glycated haemoglobin (HbA1c). Conclusions In mild neuropathy no difference in IENFD at the wrist level could be detected between diabetic and non-diabetic patients. Independent of diabetes, we found IENFD to be higher in hairy skin compared with glabrous skin and higher in females than in males. These results must be taken into consideration when assessing small nerve fibre pathology in the upper extremity.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1111/j.1464-5491.2009.02823.x

Full metadata record

DC FieldValue Language
dc.contributor.authorThomsen, N. O. Ben
dc.contributor.authorEnglund, E.en
dc.contributor.authorThrainsdottir, Sen
dc.contributor.authorRosén, Ien
dc.contributor.authorDahlin, L. Ben
dc.date.accessioned2009-11-20T09:51:33Z-
dc.date.available2009-11-20T09:51:33Z-
dc.date.issued2009-11-01-
dc.date.submitted2009-11-20-
dc.identifier.citationDiabet Med. 2009, 26(11):1120-6en
dc.identifier.issn07423071-
dc.identifier.issn14645491-
dc.identifier.doi10.1111/j.1464-5491.2009.02823.x-
dc.identifier.urihttp://hdl.handle.net/2336/86554-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractAims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies were obtained in conjunction with surgical carpal tunnel release. Biopsies were immunostained with anti-protein gene product (PGP) 9.5. The IENFD was quantified using manual counting by light microscopy. Results We could not demonstrate significant differences in IENFD between diabetic or non-diabetic patients. Additionally, no differences were found between patients with Type 1 and Type 2 diabetes or in diabetic patients with and without neurophysiologic signs of mild peripheral neuropathy. However, the IENFD was significantly higher in hairy skin compared with glabrous skin. Furthermore, the IENFD was significantly higher in females than in males and correlated with age, but not with duration of diabetes or glycated haemoglobin (HbA1c). Conclusions In mild neuropathy no difference in IENFD at the wrist level could be detected between diabetic and non-diabetic patients. Independent of diabetes, we found IENFD to be higher in hairy skin compared with glabrous skin and higher in females than in males. These results must be taken into consideration when assessing small nerve fibre pathology in the upper extremity.en
dc.language.isoisen
dc.publisherBlackwell Publishing Inc.en
dc.relation.urlhttp://dx.doi.org/10.1111/j.1464-5491.2009.02823.xen
dc.subject.meshDiabetesen
dc.subject.meshCarpal Tunnel Syndromeen
dc.titleIntraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patientsis
dc.typeArticleen
dc.identifier.journalDiabetic medicine : a journal of the British Diabetic Associationen
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