2.50
Hdl Handle:
http://hdl.handle.net/2336/87178
Title:
Familial aggregation of IgAD and autoimmunity
Authors:
Jorgensen, Gudmundur H; Thorsteinsdottir, Ingunn; Gudmundsson, Sveinn; Hammarstrom, Lennart; Ludviksson, Bjorn R
Citation:
Clin. Immunol. 2009, 131(2):233-9
Issue Date:
1-May-2009
Abstract:
BACKGROUND: The prevalence of autoimmunity is thought to be increased among IgA deficient (IgAD) individuals. However, it is currently unclear if the two conditions coincide within families. OBJECTIVE: To evaluate the prevalence of autoimmunity among IgAD individuals and their 1 degrees relatives. MATERIAL AND METHODS: A total of 43 IgAD individuals (32 adults and 11 children) and all available 1 degrees relatives were evaluated by a physician. A family history of autoimmunity was obtained, together with physical examination and a structured questionnaire that focused on symptoms and signs suggestive of autoimmunity. RESULTS: Eight of the 32 (25%) adult IgAD, were found to have definite autoimmunity, with organ specific- and systemic autoimmune diseases equally distributed. None of the IgAD children had autoimmunity. Among the 1 degrees relatives, 27/269 (10%) had autoimmunity, compared to an estimate of 5% in the general population (p<0.05). CONCLUSION: Autoimmune diseases are highly prevalent in individuals with IgAD and more common in their 1 degrees relatives than expected, thus, suggesting a possible common genetic component.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1016/j.clim.2008.11.013

Full metadata record

DC FieldValue Language
dc.contributor.authorJorgensen, Gudmundur Hen
dc.contributor.authorThorsteinsdottir, Ingunnen
dc.contributor.authorGudmundsson, Sveinnen
dc.contributor.authorHammarstrom, Lennarten
dc.contributor.authorLudviksson, Bjorn Ren
dc.date.accessioned2009-12-01T16:23:19Z-
dc.date.available2009-12-01T16:23:19Z-
dc.date.issued2009-05-01-
dc.date.submitted2009-12-01-
dc.identifier.citationClin. Immunol. 2009, 131(2):233-9en
dc.identifier.issn1521-7035-
dc.identifier.pmid19167929-
dc.identifier.doi10.1016/j.clim.2008.11.013-
dc.identifier.urihttp://hdl.handle.net/2336/87178-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: The prevalence of autoimmunity is thought to be increased among IgA deficient (IgAD) individuals. However, it is currently unclear if the two conditions coincide within families. OBJECTIVE: To evaluate the prevalence of autoimmunity among IgAD individuals and their 1 degrees relatives. MATERIAL AND METHODS: A total of 43 IgAD individuals (32 adults and 11 children) and all available 1 degrees relatives were evaluated by a physician. A family history of autoimmunity was obtained, together with physical examination and a structured questionnaire that focused on symptoms and signs suggestive of autoimmunity. RESULTS: Eight of the 32 (25%) adult IgAD, were found to have definite autoimmunity, with organ specific- and systemic autoimmune diseases equally distributed. None of the IgAD children had autoimmunity. Among the 1 degrees relatives, 27/269 (10%) had autoimmunity, compared to an estimate of 5% in the general population (p<0.05). CONCLUSION: Autoimmune diseases are highly prevalent in individuals with IgAD and more common in their 1 degrees relatives than expected, thus, suggesting a possible common genetic component.en
dc.language.isoenen
dc.relation.urlhttp://dx.doi.org/10.1016/j.clim.2008.11.013en
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAge of Onseten
dc.subject.meshAgeden
dc.subject.meshAutoimmunityen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshIgA Deficiencyen
dc.subject.meshImmunoglobulin Aen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPedigreeen
dc.subject.meshQuestionnairesen
dc.titleFamilial aggregation of IgAD and autoimmunityen
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine, University of Iceland, Reykjavík, Iceland.en
dc.identifier.journalClinical immunology (Orlando, Fla.)en

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