Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

2.50
Hdl Handle:
http://hdl.handle.net/2336/87460
Title:
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
Authors:
Gudmundsson, Julius; Sulem, Patrick; Rafnar, Thorunn; Bergthorsson, Jon T; Manolescu, Andrei; Gudbjartsson, Daniel; Agnarsson, Bjarni A; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R; Blondal, Thorarinn; Jakobsdottir, Margret; Stacey, Simon N; Kostic, Jelena; Kristinsson, Kari T; Birgisdottir, Birgitta; Ghosh, Shyamali; Magnusdottir, Droplaug N; Thorlacius, Steinunn; Thorleifsson, Gudmar; Zheng, S Lilly; Sun, Jielin; Chang, Bao-Li; Elmore, J Bradford; Breyer, Joan P; McReynolds, Kate M; Bradley, Kevin M; Yaspan, Brian L; Wiklund, Fredrik; Stattin, Par; Lindström, Sara; Adami, Hans-Olov; McDonnell, Shannon K; Schaid, Daniel J; Cunningham, Julie M; Wang, Liang; Cerhan, James R; St Sauver, Jennifer L; Isaacs, Sara D; Wiley, Kathleen E; Partin, Alan W; Walsh, Patrick C; Polo, Sonia; Ruiz-Echarri, Manuel; Navarrete, Sebastian; Fuertes, Fernando; Saez, Berta; Godino, Javier; Weijerman, Philip C; Swinkels, Dorine W; Aben, Katja K; Witjes, J Alfred; Suarez, Brian K; Helfand, Brian T; Frigge, Michael L; Kristjansson, Kristleifur; Ober, Carole; Jonsson, Eirikur; Einarsson, Gudmundur V; Xu, Jianfeng; Gronberg, Henrik; Smith, Jeffrey R; Thibodeau, Stephen N; Isaacs, William B; Catalona, William J; Mayordomo, Jose I; Kiemeney, Lambertus A; Barkardottir, Rosa B; Gulcher, Jeffrey R; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari
Citation:
Nat. Genet. 2008, 40(3):281-3
Issue Date:
1-Mar-2008
Abstract:
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
Description:
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open
Additional Links:
http://dx.doi.org/10.1038/ng.89

Full metadata record

DC FieldValue Language
dc.contributor.authorGudmundsson, Juliusen
dc.contributor.authorSulem, Patricken
dc.contributor.authorRafnar, Thorunnen
dc.contributor.authorBergthorsson, Jon Ten
dc.contributor.authorManolescu, Andreien
dc.contributor.authorGudbjartsson, Danielen
dc.contributor.authorAgnarsson, Bjarni Aen
dc.contributor.authorSigurdsson, Asgeiren
dc.contributor.authorBenediktsdottir, Kristrun Ren
dc.contributor.authorBlondal, Thorarinnen
dc.contributor.authorJakobsdottir, Margreten
dc.contributor.authorStacey, Simon Nen
dc.contributor.authorKostic, Jelenaen
dc.contributor.authorKristinsson, Kari Ten
dc.contributor.authorBirgisdottir, Birgittaen
dc.contributor.authorGhosh, Shyamalien
dc.contributor.authorMagnusdottir, Droplaug Nen
dc.contributor.authorThorlacius, Steinunnen
dc.contributor.authorThorleifsson, Gudmaren
dc.contributor.authorZheng, S Lillyen
dc.contributor.authorSun, Jielinen
dc.contributor.authorChang, Bao-Lien
dc.contributor.authorElmore, J Bradforden
dc.contributor.authorBreyer, Joan Pen
dc.contributor.authorMcReynolds, Kate Men
dc.contributor.authorBradley, Kevin Men
dc.contributor.authorYaspan, Brian Len
dc.contributor.authorWiklund, Fredriken
dc.contributor.authorStattin, Paren
dc.contributor.authorLindström, Saraen
dc.contributor.authorAdami, Hans-Oloven
dc.contributor.authorMcDonnell, Shannon Ken
dc.contributor.authorSchaid, Daniel Jen
dc.contributor.authorCunningham, Julie Men
dc.contributor.authorWang, Liangen
dc.contributor.authorCerhan, James Ren
dc.contributor.authorSt Sauver, Jennifer Len
dc.contributor.authorIsaacs, Sara Den
dc.contributor.authorWiley, Kathleen Een
dc.contributor.authorPartin, Alan Wen
dc.contributor.authorWalsh, Patrick Cen
dc.contributor.authorPolo, Soniaen
dc.contributor.authorRuiz-Echarri, Manuelen
dc.contributor.authorNavarrete, Sebastianen
dc.contributor.authorFuertes, Fernandoen
dc.contributor.authorSaez, Bertaen
dc.contributor.authorGodino, Javieren
dc.contributor.authorWeijerman, Philip Cen
dc.contributor.authorSwinkels, Dorine Wen
dc.contributor.authorAben, Katja Ken
dc.contributor.authorWitjes, J Alfreden
dc.contributor.authorSuarez, Brian Ken
dc.contributor.authorHelfand, Brian Ten
dc.contributor.authorFrigge, Michael Len
dc.contributor.authorKristjansson, Kristleifuren
dc.contributor.authorOber, Caroleen
dc.contributor.authorJonsson, Eirikuren
dc.contributor.authorEinarsson, Gudmundur Ven
dc.contributor.authorXu, Jianfengen
dc.contributor.authorGronberg, Henriken
dc.contributor.authorSmith, Jeffrey Ren
dc.contributor.authorThibodeau, Stephen Nen
dc.contributor.authorIsaacs, William Ben
dc.contributor.authorCatalona, William Jen
dc.contributor.authorMayordomo, Jose Ien
dc.contributor.authorKiemeney, Lambertus Aen
dc.contributor.authorBarkardottir, Rosa Ben
dc.contributor.authorGulcher, Jeffrey Ren
dc.contributor.authorThorsteinsdottir, Unnuren
dc.contributor.authorKong, Augustineen
dc.contributor.authorStefansson, Karien
dc.date.accessioned2009-12-07T14:07:29Zen
dc.date.available2009-12-07T14:07:29Zen
dc.date.issued2008-03-01en
dc.date.submitted2009-12-07en
dc.identifier.citationNat. Genet. 2008, 40(3):281-3en
dc.identifier.issn1546-1718en
dc.identifier.pmid18264098en
dc.identifier.doi10.1038/ng.89en
dc.identifier.urihttp://hdl.handle.net/2336/87460en
dc.descriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Openen
dc.description.abstractWe conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.89en
dc.subject.meshCase-Control Studiesen
dc.subject.meshChromosomes, Human, Pair 2en
dc.subject.meshChromosomes, Human, Xen
dc.subject.meshGene Frequencyen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenetic Screeningen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLinkage Disequilibriumen
dc.subject.meshMaleen
dc.subject.meshNetherlandsen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshProstatic Neoplasmsen
dc.subject.meshSpainen
dc.subject.meshSwedenen
dc.subject.meshUnited Statesen
dc.titleCommon sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.en
dc.typeArticleen
dc.contributor.departmentdeCODE genetics, 101 Reykjavik, Iceland. julius@decode.isen
dc.identifier.journalNature geneticsen

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