Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia

2.50
Hdl Handle:
http://hdl.handle.net/2336/90596
Title:
Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia
Authors:
Haraldsson, Haraldur Magnus; Ettinger, Ulrich; Magnusdottir, Brynja B; Sigmundsson, Thordur; Sigurdsson, Engilbert; Ingason, Andres; Petursson, Hannes
Citation:
Schizophr Bull. 2010, 36(1):157-64
Issue Date:
1-Jan-2010
Abstract:
The catechol-O-methyltransferase (COMT) enzyme catabolizes dopamine. The val(158)met single nucleotide polymorphism (rs4680) in the COMT gene has received considerable attention as a candidate gene for schizophrenia as well as for frontally mediated cognitive functions. Antisaccade performance is a good measure of frontal lobe integrity. Deficits on the task are considered a trait marker for schizophrenia. The aim of this study was to investigate the association of COMT val(158)met polymorphism with antisaccade eye movements in schizophrenia patients and healthy controls. Schizophrenia patients (N = 105) and healthy controls (N = 95) underwent infrared oculographic assessment of antisaccades. Subjects were genotyped for COMT val(158)met and divided into 3 groups according to genotype (val/val, val/met, and met/met). Patients displayed significantly more reflexive errors, longer and more variable latency, and lower amplitude gain than controls (all P < 0.02). A greater number of val(158) alleles was associated with shorter (P = 0.045) and less variable (P = 0.028) antisaccade latency and, nonsignificantly, with lower reflexive error rate (P = 0.056). None of these variables showed a group-by-genotype interaction (P > 0.1). There were no significant associations of genotype with measures of amplitude gain or spatial error (P > 0.2). The results suggest that COMT val(158) carrier status is associated with better performance on the antisaccade task. Possible explanations of this finding are discussed.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1093/schbul/sbn064

Full metadata record

DC FieldValue Language
dc.contributor.authorHaraldsson, Haraldur Magnusen
dc.contributor.authorEttinger, Ulrichen
dc.contributor.authorMagnusdottir, Brynja Ben
dc.contributor.authorSigmundsson, Thorduren
dc.contributor.authorSigurdsson, Engilberten
dc.contributor.authorIngason, Andresen
dc.contributor.authorPetursson, Hannesen
dc.date.accessioned2010-01-26T10:07:53Z-
dc.date.available2010-01-26T10:07:53Z-
dc.date.issued2010-01-01-
dc.date.submitted2010-01-26-
dc.identifier.citationSchizophr Bull. 2010, 36(1):157-64en
dc.identifier.issn1745-1701-
dc.identifier.pmid18562342-
dc.identifier.doi10.1093/schbul/sbn064-
dc.identifier.urihttp://hdl.handle.net/2336/90596-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe catechol-O-methyltransferase (COMT) enzyme catabolizes dopamine. The val(158)met single nucleotide polymorphism (rs4680) in the COMT gene has received considerable attention as a candidate gene for schizophrenia as well as for frontally mediated cognitive functions. Antisaccade performance is a good measure of frontal lobe integrity. Deficits on the task are considered a trait marker for schizophrenia. The aim of this study was to investigate the association of COMT val(158)met polymorphism with antisaccade eye movements in schizophrenia patients and healthy controls. Schizophrenia patients (N = 105) and healthy controls (N = 95) underwent infrared oculographic assessment of antisaccades. Subjects were genotyped for COMT val(158)met and divided into 3 groups according to genotype (val/val, val/met, and met/met). Patients displayed significantly more reflexive errors, longer and more variable latency, and lower amplitude gain than controls (all P < 0.02). A greater number of val(158) alleles was associated with shorter (P = 0.045) and less variable (P = 0.028) antisaccade latency and, nonsignificantly, with lower reflexive error rate (P = 0.056). None of these variables showed a group-by-genotype interaction (P > 0.1). There were no significant associations of genotype with measures of amplitude gain or spatial error (P > 0.2). The results suggest that COMT val(158) carrier status is associated with better performance on the antisaccade task. Possible explanations of this finding are discussed.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://dx.doi.org/10.1093/schbul/sbn064en
dc.subject.meshGenotypeen
dc.subject.meshCatechol O-Methyltransferaseen
dc.subject.meshSchizophreniaen
dc.subject.meshDopamineen
dc.subject.meshValineen
dc.titleCatechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophreniaen
dc.typeArticleen
dc.contributor.departmentDivision of Psychiatry, Landspitali University Hospital, Hringbraut, 101 Reykjavik, Iceland. hmagnus@landspitali.isen
dc.identifier.journalSchizophrenia bulletinen

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