Coronary heart disease mortality amongst non-insulin-dependent diabetic subjects in Iceland: the independent effect of diabetes. The Reykjavik Study 17-year follow up

2.50
Hdl Handle:
http://hdl.handle.net/2336/93617
Title:
Coronary heart disease mortality amongst non-insulin-dependent diabetic subjects in Iceland: the independent effect of diabetes. The Reykjavik Study 17-year follow up
Authors:
Vilbergsson, S; Sigurdsson, G; Sigvaldason, H; Sigfusson, N
Citation:
J. Intern. Med. 1998, 244(4):309-16
Issue Date:
1-Oct-1998
Abstract:
OBJECTIVES: The main aim of this study was to estimate the independent risk for coronary heart disease (CHD) death associated with non-insulin dependent (Type 2) diabetes (NIDDM) and effect on life expectancy. DESIGN AND SETTING: The Reykjavik Study is a prospective cardiovascular population study which started in 1967. A randomized selection procedure identified individuals for invitation to participate, based on their year and date of birth. Participants were examined in the years 1967-91 in one research clinic in Reykjavik. SUBJECTS AND METHODS: The population in this survey were Icelandic Caucasian males and females, born 1907-35 and therefore 34-79 years old when their examination was performed. Altogether 9139 males and 9773 females attended, and of those 267 males and 210 female were NIDDM as defined by a questionnaire or an oral glucose tolerance test. Other factors measured in the study included systolic and diastolic blood pressure, fasting total cholesterol, triglycerides, uric acid, smoking habits, height, and weight. The causes of death were determined by a review of all death certificates. Results. The relative risk of death from CHD (95% confidence limits), independently associated with NIDDM, was 2.0 (1.5-2.6) for males and 2.4 (1.6-3.6) for females. The relative risk of death from all causes was 1.9 (1.6-2.3) and 1.7 (1.3-2.1), respectively, for male and female diabetic patients. CONCLUSIONS: Non-insulin dependent diabetes mellitus carried twice the risk of CHD death in both sexes, independently of other risk factors. The diagnosis of NIDDM at the age 55 years reduced an individual's life expectancy by about five years, mostly because of increased CHD death rate.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1046/j.1365-2796.1998.00368.x

Full metadata record

DC FieldValue Language
dc.contributor.authorVilbergsson, Sen
dc.contributor.authorSigurdsson, Gen
dc.contributor.authorSigvaldason, Hen
dc.contributor.authorSigfusson, Nen
dc.date.accessioned2010-03-04T11:29:51Z-
dc.date.available2010-03-04T11:29:51Z-
dc.date.issued1998-10-01-
dc.date.submitted2010-03-04-
dc.identifier.citationJ. Intern. Med. 1998, 244(4):309-16en
dc.identifier.issn0954-6820-
dc.identifier.pmid9797494-
dc.identifier.doi10.1046/j.1365-2796.1998.00368.x-
dc.identifier.urihttp://hdl.handle.net/2336/93617-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVES: The main aim of this study was to estimate the independent risk for coronary heart disease (CHD) death associated with non-insulin dependent (Type 2) diabetes (NIDDM) and effect on life expectancy. DESIGN AND SETTING: The Reykjavik Study is a prospective cardiovascular population study which started in 1967. A randomized selection procedure identified individuals for invitation to participate, based on their year and date of birth. Participants were examined in the years 1967-91 in one research clinic in Reykjavik. SUBJECTS AND METHODS: The population in this survey were Icelandic Caucasian males and females, born 1907-35 and therefore 34-79 years old when their examination was performed. Altogether 9139 males and 9773 females attended, and of those 267 males and 210 female were NIDDM as defined by a questionnaire or an oral glucose tolerance test. Other factors measured in the study included systolic and diastolic blood pressure, fasting total cholesterol, triglycerides, uric acid, smoking habits, height, and weight. The causes of death were determined by a review of all death certificates. Results. The relative risk of death from CHD (95% confidence limits), independently associated with NIDDM, was 2.0 (1.5-2.6) for males and 2.4 (1.6-3.6) for females. The relative risk of death from all causes was 1.9 (1.6-2.3) and 1.7 (1.3-2.1), respectively, for male and female diabetic patients. CONCLUSIONS: Non-insulin dependent diabetes mellitus carried twice the risk of CHD death in both sexes, independently of other risk factors. The diagnosis of NIDDM at the age 55 years reduced an individual's life expectancy by about five years, mostly because of increased CHD death rate.en
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://dx.doi.org/10.1046/j.1365-2796.1998.00368.xen
dc.subject.meshAdulten
dc.subject.meshAge Distributionen
dc.subject.meshAgeden
dc.subject.meshCoronary Diseaseen
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshGlucose Tolerance Testen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLife Expectancyen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshProportional Hazards Modelsen
dc.subject.meshRisken
dc.subject.meshRisk Factorsen
dc.subject.meshSurvival Rateen
dc.titleCoronary heart disease mortality amongst non-insulin-dependent diabetic subjects in Iceland: the independent effect of diabetes. The Reykjavik Study 17-year follow upen
dc.typeArticleen
dc.contributor.departmentThe Icelandic Heart Association, University of Iceland, Department of Medicine, Reykjavik.en
dc.identifier.journalJournal of internal medicineen

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