2.50
Hdl Handle:
http://hdl.handle.net/2336/93632
Title:
The effects of IL-6 on cell adhesion and e-cadherin expression in breast cancer.
Authors:
Asgeirsson, K S; Olafsdóttir, K; Jonasson, J G; Ogmundsdottir, H M
Citation:
Cytokine. 1998, 10(9):720-8
Issue Date:
1-Sep-1998
Abstract:
Interleukin 6 (IL-6) is a pleiotropic inflammatory cytokine and its role in cancer is not yet clear. The effects of IL-6 on four breast cancer cell lines and normal mammary epithelium, cultured from milk were tested. Four different patterns of response to IL-6 were found depending on the differentiation status of the cells. In normal mammary epithelial cultures, the effects of IL-6 were mainly growth inhibitory, whereas in MCF-7, IL-6 had growth inhibitory and anti-adhesive effects. In T-47D and ZR-75-1 the anti-adhesive effects were prominent although the growth inhibitory effects were not. These anti-adhesive effects were associated with epithelioid to fibroblastoid morphological changes and a local decrease in E-cadherin expression. In the highly invasive cell line MDA-MB-231, which does not express E-cadherin, no effects of IL-6 were seen. IL-6 levels in the serum of 60 breast cancer patients were found to be increased in 27% (16/60) compared to 2% (1/50) in a control group. Furthermore, it was found that altered E-cadherin expression was seen in 69% of the primary tumours, although no significant association was found between raised serum IL-6 levels and altered E-cadherin expression. Finally IL-6 serum levels did not effect the survival of breast cancer patients. The authors therefore implicate IL-6 as a possible factor important in breast cancer progression and metastasis formation, although the clinical significance of this cytokine in breast cancer patients could not be established.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1006/cyto.1998.0349

Full metadata record

DC FieldValue Language
dc.contributor.authorAsgeirsson, K Sen
dc.contributor.authorOlafsdóttir, Ken
dc.contributor.authorJonasson, J Gen
dc.contributor.authorOgmundsdottir, H Men
dc.date.accessioned2010-03-04T13:48:25Z-
dc.date.available2010-03-04T13:48:25Z-
dc.date.issued1998-09-01-
dc.date.submitted2010-03-04-
dc.identifier.citationCytokine. 1998, 10(9):720-8en
dc.identifier.issn1043-4666-
dc.identifier.pmid9770334-
dc.identifier.doi10.1006/cyto.1998.0349-
dc.identifier.urihttp://hdl.handle.net/2336/93632-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractInterleukin 6 (IL-6) is a pleiotropic inflammatory cytokine and its role in cancer is not yet clear. The effects of IL-6 on four breast cancer cell lines and normal mammary epithelium, cultured from milk were tested. Four different patterns of response to IL-6 were found depending on the differentiation status of the cells. In normal mammary epithelial cultures, the effects of IL-6 were mainly growth inhibitory, whereas in MCF-7, IL-6 had growth inhibitory and anti-adhesive effects. In T-47D and ZR-75-1 the anti-adhesive effects were prominent although the growth inhibitory effects were not. These anti-adhesive effects were associated with epithelioid to fibroblastoid morphological changes and a local decrease in E-cadherin expression. In the highly invasive cell line MDA-MB-231, which does not express E-cadherin, no effects of IL-6 were seen. IL-6 levels in the serum of 60 breast cancer patients were found to be increased in 27% (16/60) compared to 2% (1/50) in a control group. Furthermore, it was found that altered E-cadherin expression was seen in 69% of the primary tumours, although no significant association was found between raised serum IL-6 levels and altered E-cadherin expression. Finally IL-6 serum levels did not effect the survival of breast cancer patients. The authors therefore implicate IL-6 as a possible factor important in breast cancer progression and metastasis formation, although the clinical significance of this cytokine in breast cancer patients could not be established.en
dc.language.isoenen
dc.publisherAcademic Pressen
dc.relation.urlhttp://dx.doi.org/10.1006/cyto.1998.0349en
dc.subject.meshBreasten
dc.subject.meshBreast Neoplasmsen
dc.subject.meshCadherinsen
dc.subject.meshCell Adhesionen
dc.subject.meshCell Divisionen
dc.subject.meshEpithelial Cellsen
dc.subject.meshFemaleen
dc.subject.meshGene Expression Regulation, Neoplasticen
dc.subject.meshGrowth Inhibitorsen
dc.subject.meshHumansen
dc.subject.meshInterleukin-6en
dc.subject.meshNeoplasm Proteinsen
dc.subject.meshTumor Cells, Cultureden
dc.titleThe effects of IL-6 on cell adhesion and e-cadherin expression in breast cancer.en
dc.typeArticleen
dc.contributor.departmentMolecular and Cell Biology Laboratory, Icelandic Cancer Society, P.O. Box 5420, Reykjavik, Iceland.en
dc.identifier.journalCytokineen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.