2.50
Hdl Handle:
http://hdl.handle.net/2336/96605
Title:
Several common variants modulate heart rate, PR interval and QRS duration
Authors:
Holm, Hilma; Gudbjartsson, Daniel F; Arnar, David O; Thorleifsson, Gudmar; Thorgeirsson, Gudmundur; Stefansdottir, Hrafnhildur; Gudjonsson, Sigurjon A; Jonasdottir, Aslaug; Mathiesen, Ellisiv B; Njølstad, Inger; Nyrnes, Audhild; Wilsgaard, Tom; Hald, Erin M; Hveem, Kristian; Stoltenberg, Camilla; Løchen, Maja-Lisa; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
Citation:
Nat. Genet. 2010, 42(2):117-22
Issue Date:
1-Feb-2010
Abstract:
Electrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate heart rate, PR interval and QRS duration in individuals of European descent, we performed a genome-wide association study in approximately 10,000 individuals and followed up the top signals in an additional approximately 10,000 individuals. We identified several genome-wide significant associations (with P < 1.6 x 10(-7)). We identified one locus for heart rate (MYH6), four for PR interval (TBX5, SCN10A, CAV1 and ARHGAP24) and four for QRS duration (TBX5, SCN10A, 6p21 and 10q21). We tested for association between these loci and subjects with selected arrhythmias in Icelandic and Norwegian case-control sample sets. We observed correlations between TBX5 and CAV1 and atrial fibrillation (P = 4.0 x 10(-5) and P = 0.00032, respectively), between TBX5 and advanced atrioventricular block (P = 0.0067), and between SCN10A and pacemaker implantation (P = 0.0029). We also replicated previously described associations with the QT interval.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.511

Full metadata record

DC FieldValue Language
dc.contributor.authorHolm, Hilmaen
dc.contributor.authorGudbjartsson, Daniel Fen
dc.contributor.authorArnar, David Oen
dc.contributor.authorThorleifsson, Gudmaren
dc.contributor.authorThorgeirsson, Gudmunduren
dc.contributor.authorStefansdottir, Hrafnhilduren
dc.contributor.authorGudjonsson, Sigurjon Aen
dc.contributor.authorJonasdottir, Aslaugen
dc.contributor.authorMathiesen, Ellisiv Ben
dc.contributor.authorNjølstad, Ingeren
dc.contributor.authorNyrnes, Audhilden
dc.contributor.authorWilsgaard, Tomen
dc.contributor.authorHald, Erin Men
dc.contributor.authorHveem, Kristianen
dc.contributor.authorStoltenberg, Camillaen
dc.contributor.authorLøchen, Maja-Lisaen
dc.contributor.authorKong, Augustineen
dc.contributor.authorThorsteinsdottir, Unnuren
dc.contributor.authorStefansson, Karien
dc.date.accessioned2010-04-15T15:14:51Z-
dc.date.available2010-04-15T15:14:51Z-
dc.date.issued2010-02-01-
dc.date.submitted2010-04-15-
dc.identifier.citationNat. Genet. 2010, 42(2):117-22en
dc.identifier.issn1546-1718-
dc.identifier.pmid20062063-
dc.identifier.doi10.1038/ng.511-
dc.identifier.urihttp://hdl.handle.net/2336/96605-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractElectrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate heart rate, PR interval and QRS duration in individuals of European descent, we performed a genome-wide association study in approximately 10,000 individuals and followed up the top signals in an additional approximately 10,000 individuals. We identified several genome-wide significant associations (with P < 1.6 x 10(-7)). We identified one locus for heart rate (MYH6), four for PR interval (TBX5, SCN10A, CAV1 and ARHGAP24) and four for QRS duration (TBX5, SCN10A, 6p21 and 10q21). We tested for association between these loci and subjects with selected arrhythmias in Icelandic and Norwegian case-control sample sets. We observed correlations between TBX5 and CAV1 and atrial fibrillation (P = 4.0 x 10(-5) and P = 0.00032, respectively), between TBX5 and advanced atrioventricular block (P = 0.0067), and between SCN10A and pacemaker implantation (P = 0.0029). We also replicated previously described associations with the QT interval.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.511en
dc.subject.meshAgeden
dc.subject.meshArrhythmias, Cardiacen
dc.subject.meshAtrial Fibrillationen
dc.subject.meshAtrioventricular Blocken
dc.subject.meshCardiac Myosinsen
dc.subject.meshElectrocardiographyen
dc.subject.meshFemaleen
dc.subject.meshGenetic Locien
dc.subject.meshGenetic Variationen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.meshHeart Conduction Systemen
dc.subject.meshHeart Rateen
dc.subject.meshIcelanden
dc.subject.meshInheritance Patternsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshMyosin Heavy Chainsen
dc.subject.meshPacemaker, Artificialen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshSick Sinus Syndromeen
dc.titleSeveral common variants modulate heart rate, PR interval and QRS durationen
dc.typeArticleen
dc.contributor.departmentdeCODE genetics, Reykjavik, Iceland. hilma.holm@decode.isen
dc.identifier.journalNature geneticsen

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