The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men

2.50
Hdl Handle:
http://hdl.handle.net/2336/97885
Title:
The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men
Authors:
Walderhaug, Espen; Herman, Aryeh Isaac; Magnusson, Andres; Morgan, Michael John; Landrø, Nils Inge
Citation:
Neurosci. Lett. 2010, 473(3):208-11
Issue Date:
1-Apr-2010
Abstract:
Reduced serotonergic neurotransmission is implicated in impulsive behavior. We studied the triallelic system of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and acute manipulation of serotonin together to further delineate the mechanisms by which serotonergic neurotransmission affects impulsivity. Fifty-two healthy participants (38 men and 14 women) underwent acute tryptophan depletion (ATD) or placebo in a randomized, double-blind, parallel group experiment. Impulsive response style was measured on two versions of the Continuous Performance Task (CPT), and calculated using signal detection theory. We observed a dose-dependent effect for the short (S') allele of the 5-HTTLPR on impulsive response style. Individuals who had the S'/S' genotype were more impulsive than individuals with the L/S' genotype. Participants with the L/S' genotype were more impulsive than those with the L/L genotype. ATD increased impulsivity in men, and decreased impulsivity in women. These data demonstrate for the first time that reduced serotonergic tone as a result of either 5-HTTLPR genotype, or experimental ATD, are both independently and additively, associated with elevated impulsive response style in Caucasian men.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1016/j.neulet.2010.02.048

Full metadata record

DC FieldValue Language
dc.contributor.authorWalderhaug, Espenen
dc.contributor.authorHerman, Aryeh Isaacen
dc.contributor.authorMagnusson, Andresen
dc.contributor.authorMorgan, Michael Johnen
dc.contributor.authorLandrø, Nils Ingeen
dc.date.accessioned2010-05-04T14:21:22Z-
dc.date.available2010-05-04T14:21:22Z-
dc.date.issued2010-04-01-
dc.date.submitted2010-05-04-
dc.identifier.citationNeurosci. Lett. 2010, 473(3):208-11en
dc.identifier.issn1872-7972-
dc.identifier.pmid20188795-
dc.identifier.doi10.1016/j.neulet.2010.02.048-
dc.identifier.urihttp://hdl.handle.net/2336/97885-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractReduced serotonergic neurotransmission is implicated in impulsive behavior. We studied the triallelic system of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and acute manipulation of serotonin together to further delineate the mechanisms by which serotonergic neurotransmission affects impulsivity. Fifty-two healthy participants (38 men and 14 women) underwent acute tryptophan depletion (ATD) or placebo in a randomized, double-blind, parallel group experiment. Impulsive response style was measured on two versions of the Continuous Performance Task (CPT), and calculated using signal detection theory. We observed a dose-dependent effect for the short (S') allele of the 5-HTTLPR on impulsive response style. Individuals who had the S'/S' genotype were more impulsive than individuals with the L/S' genotype. Participants with the L/S' genotype were more impulsive than those with the L/L genotype. ATD increased impulsivity in men, and decreased impulsivity in women. These data demonstrate for the first time that reduced serotonergic tone as a result of either 5-HTTLPR genotype, or experimental ATD, are both independently and additively, associated with elevated impulsive response style in Caucasian men.en
dc.language.isoenen
dc.publisherElsevier BVen
dc.relation.urlhttp://dx.doi.org/10.1016/j.neulet.2010.02.048en
dc.subject.meshGeneticsen
dc.subject.meshSerotoninen
dc.subject.meshTryptophanen
dc.subject.meshImpulsive Behavioren
dc.subject.meshMaleen
dc.subject.meshPubMed in Processen
dc.titleThe short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in menen
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA. espen.walderhaug@yale.eduen
dc.identifier.journalNeuroscience lettersen
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