Inflammatory cytokines in relation to adrenal response following total hip replacement

2.50
Hdl Handle:
http://hdl.handle.net/2336/9826
Title:
Inflammatory cytokines in relation to adrenal response following total hip replacement
Authors:
Bjornsson, G L; Thorsteinsson, L; Gudmundsson, K O; Jonsson, H; Gudmundsson, S; Gudbjornsson, B
Citation:
Scand. J. Immunol. 2007, 65(1):99-105
Issue Date:
1-Jan-2007
Abstract:
Our objective was to investigate the initiation and course of pro- and anti-inflammatory cytokines in early inflammatory response and to elucidate the cytokine system in relation to the adrenal response caused by stress. Seven blood samples were collected, pre- and postoperatively (0-72 h) after total hip replacement (THR) due to osteoarthritis. The following cytokines were measured using Cytometric Bead Array: interleukin-1beta (IL-1beta), IL-6, tumour necrosis factor-alpha, IL-8, IL-12 and IL-10 (B&D). Thirteen patients took part in the study (67 +/- 9 years). C-reactive protein increased from <6 to over 200 mg/l on the second post-op day. The concentration of IL-6 increased 10-fold just 3 h post-op (4-47 pg/ml) and reached its maximum value 6 h post-op (77 pg/ml; Wilcoxon test P < 0.01) Repeated measurements were also significant (Friedman P < 0.05). The concentration of IL-8 doubled the day of surgery but did not reach a significant level (Friedman test =0.069). None of the other cytokines showed any significant changes. The diurnal cortisol rhythm was interrupted after the surgery and there was a significant correlation between the cortisol secretion and IL-6 response. This study demonstrates an isolated elevation in IL-6 levels with only a minor elevation in IL-8 following THR. This pro-inflammatory response seemed to decline without activation of anti-inflammatory cytokines (IL-10), but cortisol seemed to play a complicated role in halting the acute inflammatory response.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.blackwell-synergy.com/doi/full/10.1111/j.1365-3083.2006.01872.x

Full metadata record

DC FieldValue Language
dc.contributor.authorBjornsson, G L-
dc.contributor.authorThorsteinsson, L-
dc.contributor.authorGudmundsson, K O-
dc.contributor.authorJonsson, H-
dc.contributor.authorGudmundsson, S-
dc.contributor.authorGudbjornsson, B-
dc.date.accessioned2007-03-07T08:47:33Z-
dc.date.available2007-03-07T08:47:33Z-
dc.date.issued2007-01-01-
dc.date.submitted2007-03-06-
dc.identifier.citationScand. J. Immunol. 2007, 65(1):99-105en
dc.identifier.issn0300-9475-
dc.identifier.pmid17212773-
dc.identifier.doi10.1111/j.1365-3083.2006.01872.x-
dc.identifier.otherBAB12-
dc.identifier.otherRHE12-
dc.identifier.otherORT12-
dc.identifier.urihttp://hdl.handle.net/2336/9826-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOur objective was to investigate the initiation and course of pro- and anti-inflammatory cytokines in early inflammatory response and to elucidate the cytokine system in relation to the adrenal response caused by stress. Seven blood samples were collected, pre- and postoperatively (0-72 h) after total hip replacement (THR) due to osteoarthritis. The following cytokines were measured using Cytometric Bead Array: interleukin-1beta (IL-1beta), IL-6, tumour necrosis factor-alpha, IL-8, IL-12 and IL-10 (B&D). Thirteen patients took part in the study (67 +/- 9 years). C-reactive protein increased from <6 to over 200 mg/l on the second post-op day. The concentration of IL-6 increased 10-fold just 3 h post-op (4-47 pg/ml) and reached its maximum value 6 h post-op (77 pg/ml; Wilcoxon test P < 0.01) Repeated measurements were also significant (Friedman P < 0.05). The concentration of IL-8 doubled the day of surgery but did not reach a significant level (Friedman test =0.069). None of the other cytokines showed any significant changes. The diurnal cortisol rhythm was interrupted after the surgery and there was a significant correlation between the cortisol secretion and IL-6 response. This study demonstrates an isolated elevation in IL-6 levels with only a minor elevation in IL-8 following THR. This pro-inflammatory response seemed to decline without activation of anti-inflammatory cytokines (IL-10), but cortisol seemed to play a complicated role in halting the acute inflammatory response.en
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/full/10.1111/j.1365-3083.2006.01872.xen
dc.subject.meshAdrenal Glandsen
dc.subject.meshAged, 80 and overen
dc.subject.meshAgeden
dc.subject.meshArthroplasty, Replacement, Hipen
dc.subject.meshC-Reactive Proteinen
dc.subject.meshCytokinesen
dc.subject.meshHumansen
dc.subject.meshFemaleen
dc.subject.meshHydrocortisoneen
dc.subject.meshInterleukin-10en
dc.subject.meshInterleukin-6en
dc.subject.meshInterleukin-8en
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.titleInflammatory cytokines in relation to adrenal response following total hip replacementen
dc.typeArticleen
dc.identifier.journalScandinavian journal of immunologyen
dc.format.digYES-

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