Áhrif sýruvarinna og óhúðaðra naproxen taflna á slímhúð í maga og skeifugörn : stýrð meðferðarprófun hjá tólf heilbrigðum einstaklingum
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Issue Date
1989-04-15
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Læknablaðið 1989, 5(4):121-3Abstract
In order to compare the damaging effect of enteric-coated and plain naproxen tablets on the gastric and duodenal mucosa, 12 healthy subjects were studied before and after two 7 days treatment-periods in a randomized, double-blind, double-dummy, cross-over trial. Both preparations of the drug caused mucosal lesions, but the extent of damage was significantly less in the stomach and duodenum after enteric-coated as compared to plain naproxen tablets. The subjects however were asymptomatic and did therefore not have preference for either preparation. The morning plasma naproxen concentration was significantly higher after treatment with enteric-coated naproxen than after treatment with plain tablets. The results of the study indicate that NSAIDs damage the mucosa of the stomach and duodenum partly through a local effect which can be partially prevented by enteric-coating of the tablets.Tilgangur rannsóknarinnar sem sagt er frá í þessari grein var að kanna skaðleg áhrif á magaslímhúð hjá heilbrigðum einstaklingum, sem fengu naproxen sýruvarðar töflur (húðaðar töflur með sýruheldum hjúp) og óhúðaðar naproxen töflur.
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