Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationCrit Care. 2007, 11(6):R129
AbstractINTRODUCTION: Vasopressin has been shown to increase blood pressure in catecholamine-resistant septic shock. The aim of this study was to measure the effects of low-dose vasopressin on regional (hepato-splanchnic and renal) and microcirculatory (liver, pancreas, and kidney) blood flow in septic shock. METHODS: Thirty-two pigs were anesthetized, mechanically ventilated, and randomly assigned to one of four groups (n = 8 in each). Group S (sepsis) and group SV (sepsis/vasopressin) were exposed to fecal peritonitis. Group C and group V were non-septic controls. After 240 minutes, both septic groups were resuscitated with intravenous fluids. After 300 minutes, groups V and SV received intravenous vasopressin 0.06 IU/kg per hour. Regional blood flow was measured in the hepatic and renal arteries, the portal vein, and the celiac trunk by means of ultrasonic transit time flowmetry. Microcirculatory blood flow was measured in the liver, kidney, and pancreas by means of laser Doppler flowmetry. RESULTS: In septic shock, vasopressin markedly decreased blood flow in the portal vein, by 58% after 1 hour and by 45% after 3 hours (p < 0.01), whereas flow remained virtually unchanged in the hepatic artery and increased in the celiac trunk. Microcirculatory blood flow decreased in the pancreas by 45% (p < 0.01) and in the kidney by 16% (p < 0.01) but remained unchanged in the liver. CONCLUSION: Vasopressin caused marked redistribution of splanchnic regional and microcirculatory blood flow, including a significant decrease in portal, pancreatic, and renal blood flows, whereas hepatic artery flow remained virtually unchanged. This study also showed that increased urine output does not necessarily reflect increased renal blood flow.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock.
- Authors: Hiltebrand LB, Krejci V, Jakob SM, Takala J, Sigurdsson GH
- Issue date: 2007 Jun
- Dynamic study of the distribution of microcirculatory blood flow in multiple splanchnic organs in septic shock.
- Authors: Hiltebrand LB, Krejci V, Banic A, Erni D, Wheatley AM, Sigurdsson GH
- Issue date: 2000 Sep
- Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis.
- Authors: Krejci V, Hiltebrand LB, Sigurdsson GH
- Issue date: 2006 May
- Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock.
- Authors: Krejci V, Hiltebrand LB, Erni D, Sigurdsson GH
- Issue date: 2003 Jan
- The effects of vasopressin on systemic and splanchnic hemodynamics and metabolism in endotoxin shock.
- Authors: Martikainen TJ, Tenhunen JJ, Uusaro A, Ruokonen E
- Issue date: 2003 Dec