Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Antoniou, Antonis CSinilnikova, Olga M
McGuffog, Lesley
Healey, Sue
Nevanlinna, Heli
Heikkinen, Tuomas
Simard, Jacques
Spurdle, Amanda B
Beesley, Jonathan
Chen, Xiaoqing
Neuhausen, Susan L
Ding, Yuan C
Couch, Fergus J
Wang, Xianshu
Fredericksen, Zachary
Peterlongo, Paolo
Peissel, Bernard
Bonanni, Bernardo
Viel, Alessandra
Bernard, Loris
Radice, Paolo
Szabo, Csilla I
Foretova, Lenka
Zikan, Michal
Claes, Kathleen
Greene, Mark H
Mai, Phuong L
Rennert, Gad
Lejbkowicz, Flavio
Andrulis, Irene L
Ozcelik, Hilmi
Glendon, Gord
Gerdes, Anne-Marie
Thomassen, Mads
Sunde, Lone
Caligo, Maria A
Laitman, Yael
Kontorovich, Tair
Cohen, Shimrit
Kaufman, Bella
Dagan, Efrat
Baruch, Ruth Gershoni
Friedman, Eitan
Harbst, Katja
Barbany-Bustinza, Gisela
Rantala, Johanna
Ehrencrona, Hans
Karlsson, Per
Domchek, Susan M
Nathanson, Katherine L
Osorio, Ana
Blanco, Ignacio
Lasa, Adriana
Benítez, Javier
Hamann, Ute
Hogervorst, Frans B L
Rookus, Matti A
Collee, J Margriet
Devilee, Peter
Ligtenberg, Marjolijn J
van der Luijt, Rob B
Aalfs, Cora M
Waisfisz, Quinten
Wijnen, Juul
van Roozendaal, Cornelis E P
Peock, Susan
Cook, Margaret
Frost, Debra
Oliver, Clare
Platte, Radka
Evans, D Gareth
Lalloo, Fiona
Eeles, Rosalind
Izatt, Louise
Davidson, Rosemarie
Chu, Carol
Eccles, Diana
Cole, Trevor
Hodgson, Shirley
Godwin, Andrew K
Stoppa-Lyonnet, Dominique
Buecher, Bruno
Léoné, Mélanie
Bressac-de Paillerets, Brigitte
Remenieras, Audrey
Caron, Olivier
Lenoir, Gilbert M
Sevenet, Nicolas
Longy, Michel
Ferrer, Sandra Fert
Prieur, Fabienne
Goldgar, David
Miron, Alexander
John, Esther M
Buys, Saundra S
Daly, Mary B
Hopper, John L
Terry, Mary Beth
Yassin, Yosuf
Singer, Christian
Gschwantler-Kaulich, Daphne
Staudigl, Christine
Hansen, Thomas v O
Barkardottir, Rosa Bjork
Kirchhoff, Tomas
Pal, Prodipto
Kosarin, Kristi
Offit, Kenneth
Piedmonte, Marion
Rodriguez, Gustavo C
Wakeley, Katie
Boggess, John F
Basil, Jack
Schwartz, Peter E
Blank, Stephanie V
Toland, Amanda E
Montagna, Marco
Casella, Cinzia
Imyanitov, Evgeny N
Allavena, Anna
Schmutzler, Rita K
Versmold, Beatrix
Engel, Christoph
Meindl, Alfons
Ditsch, Nina
Arnold, Norbert
Niederacher, Dieter
Deissler, Helmut
Fiebig, Britta
Suttner, Christian
Schönbuchner, Ines
Gadzicki, Dorothea
Caldes, Trinidad
de la Hoya, Miguel
Pooley, Karen A
Easton, Douglas F
Chenevix-Trench, Georgia
Issue Date
2009-11-15
Metadata
Show full item recordCitation
Hum. Mol. Genet. 2009, 18(22):4442-56Abstract
Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risks in the general population. In a previous study, we demonstrated that the minor alleles at three of these SNPs, in FGFR2, TNRC9 and MAP3K1, also confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. Three additional SNPs rs3817198 at LSP1, rs13387042 at 2q35 and rs13281615 at 8q24 have since been reported to be associated with breast cancer in the general population, and in this study we evaluated their association with breast cancer risk in 9442 BRCA1 and 5665 BRCA2 mutation carriers from 33 study centres. The minor allele of rs3817198 was associated with increased breast cancer risk only for BRCA2 mutation carriers [hazard ratio (HR) = 1.16, 95% CI: 1.07-1.25, P-trend = 2.8 x 10(-4)]. The best fit for the association of SNP rs13387042 at 2q35 with breast cancer risk was a dominant model for both BRCA1 and BRCA2 mutation carriers (BRCA1: HR = 1.14, 95% CI: 1.04-1.25, P = 0.0047; BRCA2: HR = 1.18 95% CI: 1.04-1.33, P = 0.0079). SNP rs13281615 at 8q24 was not associated with breast cancer for either BRCA1 or BRCA2 mutation carriers, but the estimated association for BRCA2 mutation carriers (per-allele HR = 1.06, 95% CI: 0.98-1.14) was consistent with odds ratio estimates derived from population-based case-control studies. The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers. There was no evidence that the associations vary by mutation type depending on whether the mutated protein is predicted to be stable or not.Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAdditional Links
http://dx.doi.org/10.1093/hmg/ddp372ae974a485f413a2113503eed53cd6c53
10.1093/hmg/ddp372
Scopus Count
Collections