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dc.contributor.authorTrotti, Lynn Marie
dc.contributor.authorBliwise, Donald L
dc.contributor.authorGreer, Sophia A
dc.contributor.authorSigurdsson, Albert P
dc.contributor.authorGudmundsdottir, Gudbjorg Birna
dc.contributor.authorWessel, Thomas
dc.contributor.authorOrganisak, Lisa M
dc.contributor.authorSigthorsson, Thor
dc.contributor.authorKristjansson, Kristleifur
dc.contributor.authorSigmundsson, Thordur
dc.contributor.authorRye, David B
dc.date.accessioned2010-06-16T14:15:03Z
dc.date.available2010-06-16T14:15:03Z
dc.date.issued2009-06-01
dc.date.submitted2010-06-16
dc.identifier.citationSleep Med. 2009, 10(6):668-71en
dc.identifier.pmid19022704
dc.identifier.doi10.1016/j.sleep.2008.06.009
dc.identifier.urihttp://hdl.handle.net/2336/104908
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: Night-to-night variability of periodic leg movements (PLMs) in restless legs syndrome (RLS) was examined to define the range of intra-subject values, impact upon diagnosing RLS, and clinical correlates. METHODS: Twenty RLS patients were monitored for 10-15 nights using a validated, tri-axial accelerometer worn on the ankle. RESULTS: The mean difference in PLMs index (PLMI) between the lowest and highest night was 25.1/h (range: 3.9-73.8). Inter-subject differences accounted for nearly five times the variance in PLMI relative to between nights within an individual. Based on a single night of recording, PLMI criterion thresholds of 5, 10, and 15/h were exceeded on approximately 70.1%, 51.9% and 34.1% of individual nights among these patients. Based on five randomly sampled nights of recordings, the likelihood that such thresholds were met on at least a single night increased to 91.2%, 80.8% and 62.7%, respectively. Women exhibited greater variability. CONCLUSIONS: Variability in PLMs within RLS subjects was substantial, yet individuals' characteristic PLM level represented a quantitative trait. Variability was unrelated to age or scores on scales of RLS severity, sleepiness, functional status, and mood. A larger number of recording nights increased the likelihood that any criterion was reached.
dc.language.isoenen
dc.publisherElsevier Scienceen
dc.relation.urlhttp://dx.doi.org/10.1016/j.sleep.2008.06.009en
dc.subject.meshAdulten
dc.subject.meshAnalysis of Varianceen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIndividualityen
dc.subject.meshLikelihood Functionsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshMonitoring, Physiologicen
dc.subject.meshNocturnal Myoclonus Syndromeen
dc.subject.meshPolysomnographyen
dc.subject.meshRestless Legs Syndromeen
dc.subject.meshSex Factorsen
dc.subject.meshYoung Adulten
dc.titleCorrelates of PLMs variability over multiple nights and impact upon RLS diagnosisen
dc.typeArticleen
dc.identifier.eissn1878-5506
dc.contributor.departmentDepartment of Neurology and Program in Sleep, Emory University, 101 Woodruff Circle-WMRB, Suite 6000, Atlanta, GA 30322, USA. lbecke2@emory.eduen
dc.identifier.journalSleep medicineen
html.description.abstractOBJECTIVE: Night-to-night variability of periodic leg movements (PLMs) in restless legs syndrome (RLS) was examined to define the range of intra-subject values, impact upon diagnosing RLS, and clinical correlates. METHODS: Twenty RLS patients were monitored for 10-15 nights using a validated, tri-axial accelerometer worn on the ankle. RESULTS: The mean difference in PLMs index (PLMI) between the lowest and highest night was 25.1/h (range: 3.9-73.8). Inter-subject differences accounted for nearly five times the variance in PLMI relative to between nights within an individual. Based on a single night of recording, PLMI criterion thresholds of 5, 10, and 15/h were exceeded on approximately 70.1%, 51.9% and 34.1% of individual nights among these patients. Based on five randomly sampled nights of recordings, the likelihood that such thresholds were met on at least a single night increased to 91.2%, 80.8% and 62.7%, respectively. Women exhibited greater variability. CONCLUSIONS: Variability in PLMs within RLS subjects was substantial, yet individuals' characteristic PLM level represented a quantitative trait. Variability was unrelated to age or scores on scales of RLS severity, sleepiness, functional status, and mood. A larger number of recording nights increased the likelihood that any criterion was reached.


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