Possible association of a cholecystokinin promotor polymorphism (CCK-36CT) with panic disorder
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationAm. J. Med. Genet. 1998, 81(3):228-34
AbstractWe searched for mutations in the CCK gene in panic disorder with single-strand conformational polymorphism (SSCP) analysis of the three exons and promotor region of the gene. We found a C-->T transition at position -36 (CCK(-36C-->T)) in a GC box, a binding site for transcription factor Sp1, in the promotor region. The allele frequency was 0.168 (95% CI, 0.116-0.221) in 98 persons with panic disorder and 0.083 (95% CI, 0.059-0.107) in 247 geographically matched, unscreened controls. A transmission disequilibrium test based on panic disorder as the affected phenotype was nonsignificant (chi2 = 0.93), but when panic disorder or attacks were considered as affected, statistically significant transmission disequilibrium was detected (chi2 = 4.00, P < 0.05). Linkage analysis was uninformative. In exploratory analyses to search for clinical correlations, the "T" allele was found in 59% of 22 persons with panic attacks but not panic disorder, compared with 31% of those who met the criteria for panic disorder. An association between the CCK polymorphism and panic disorder cannot be considered established due to the inconsistencies in the results noted above, but if the provisional association can be replicated, the findings are consistent with CCK(-36C-->T) being a disease-susceptibility allele that alone is neither necessary nor sufficient to cause panic disorder but that increases vulnerability by acting epistatically.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder.
- Authors: Hösing VG, Schirmacher A, Kuhlenbäumer G, Freitag C, Sand P, Schlesiger C, Jacob C, Fritze J, Franke P, Rietschel M, Garritsen H, Nöthen MM, Fimmers R, Stögbauer F, Deckert J
- Issue date: 2004
- Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder.
- Authors: Kato T, Wang ZW, Zoega T, Crowe RR
- Issue date: 1996 Jul 26
- Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia.
- Authors: Hattori E, Ebihara M, Yamada K, Ohba H, Shibuya H, Yoshikawa T
- Issue date: 2001 Jul
- No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder.
- Authors: Hamilton SP, Slager SL, Helleby L, Heiman GA, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA
- Issue date: 2001 Jan
- Investigation of cholecystokinin system genes in panic disorder.
- Authors: Kennedy JL, Bradwejn J, Koszycki D, King N, Crowe R, Vincent J, Fourie O
- Issue date: 1999 May