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dc.contributor.authorKølendorf, Klaus
dc.contributor.authorEriksson, Johan
dc.contributor.authorBirkeland, Kåre I
dc.contributor.authorKjellström, Thomas
dc.contributor.authorHreidarsson, Astradur B
dc.date.accessioned2010-08-31T09:58:30Z
dc.date.available2010-08-31T09:58:30Z
dc.date.issued2004-04-01
dc.date.submitted2010-08-31
dc.identifier.citationDiabetes Res. Clin. Pract. 2004, 64(1):33-40en
dc.identifier.issn0168-8227
dc.identifier.pmid15036825
dc.identifier.doi10.1016/j.diabres.2003.10.006
dc.identifier.urihttp://hdl.handle.net/2336/110493
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractA total of 385 drug-therapy naïve patients, with inadequately controlled type 2 diabetes, were randomised into a multinational, parallel-group study to compare two strategies for dose titration of the oral hypoglycaemic agent repaglinide. Patients were allocated to either a fasting blood glucose (FBG) monitoring group with titration target 4.4-6.1 mmol/l or to a post-prandial blood glucose (PPBG) monitoring group with titration target 4.4-8.0 mmol/l. An initial titration period of up to 8 weeks was followed by a 12-week treatment period. Glycaemic control and hypoglycaemic outcomes were compared for the respective groups. HbA(1c) decreased significantly more in the FBG monitoring group by a mean of 1.38% compared to the PPBG group by a mean of 1.22% (P=0.03). The glycaemic control targets were met by fewer patients in the FBG group than in the PPBG group (57% versus 86% (P<0.001)) despite a higher mean dose of repaglinide in the FBG group. The within-patient blood glucose variability was significantly lower in the FBG group than in the PPBG group (P<0.001). In conclusion, repaglinide lowered the HbA(1c) effectively and safely in both groups and self-monitored FBG is a suitable parameter for titration of repaglinide. Whether a lower PPBG target might be as good a guide as FBG for titration of repaglinide should be addressed in a future study.
dc.language.isoenen
dc.publisherElsevier Scientific Publishersen
dc.relation.urlhttp://dx.doi.org/10.1016/j.diabres.2003.10.006en
dc.subject.meshAdulten
dc.subject.meshBlood Glucoseen
dc.subject.meshCarbamatesen
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshFastingen
dc.subject.meshFemaleen
dc.subject.meshHemoglobin A, Glycosylateden
dc.subject.meshHumansen
dc.subject.meshHypoglycemic Agentsen
dc.subject.meshMaleen
dc.subject.meshPiperidinesen
dc.subject.meshPostprandial Perioden
dc.subject.meshSafetyen
dc.titleDose titration of repaglinide in patients with inadequately controlled type 2 diabetesen
dc.typeArticleen
dc.contributor.departmentRoskilde County Hospital, Koge 4000, Denmark. klaus@kolendorf.dken
dc.identifier.journalDiabetes research and clinical practiceen
html.description.abstractA total of 385 drug-therapy naïve patients, with inadequately controlled type 2 diabetes, were randomised into a multinational, parallel-group study to compare two strategies for dose titration of the oral hypoglycaemic agent repaglinide. Patients were allocated to either a fasting blood glucose (FBG) monitoring group with titration target 4.4-6.1 mmol/l or to a post-prandial blood glucose (PPBG) monitoring group with titration target 4.4-8.0 mmol/l. An initial titration period of up to 8 weeks was followed by a 12-week treatment period. Glycaemic control and hypoglycaemic outcomes were compared for the respective groups. HbA(1c) decreased significantly more in the FBG monitoring group by a mean of 1.38% compared to the PPBG group by a mean of 1.22% (P=0.03). The glycaemic control targets were met by fewer patients in the FBG group than in the PPBG group (57% versus 86% (P<0.001)) despite a higher mean dose of repaglinide in the FBG group. The within-patient blood glucose variability was significantly lower in the FBG group than in the PPBG group (P<0.001). In conclusion, repaglinide lowered the HbA(1c) effectively and safely in both groups and self-monitored FBG is a suitable parameter for titration of repaglinide. Whether a lower PPBG target might be as good a guide as FBG for titration of repaglinide should be addressed in a future study.


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