• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Antoniou, Antonis C
Sinilnikova, Olga M
Simard, Jacques
Léoné, Mélanie
Dumont, Martine
Neuhausen, Susan L
Struewing, Jeffery P
Stoppa-Lyonnet, Dominique
Barjhoux, Laure
Hughes, David J
Coupier, Isabelle
Belotti, Muriel
Lasset, Christine
Bonadona, Valérie
Bignon, Yves-Jean
Rebbeck, Timothy R
Wagner, Theresa
Lynch, Henry T
Domchek, Susan M
Nathanson, Katherine L
Garber, Judy E
Weitzel, Jeffrey
Narod, Steven A
Tomlinson, Gail
Olopade, Olufunmilayo I
Godwin, Andrew
Isaacs, Claudine
Jakubowska, Anna
Lubinski, Jan
Gronwald, Jacek
Górski, Bohdan
Byrski, Tomasz
Huzarski, Tomasz
Peock, Susan
Cook, Margaret
Baynes, Caroline
Murray, Alexandra
Rogers, Mark
Daly, Peter A
Dorkins, Huw
Schmutzler, Rita K
Versmold, Beatrix
Engel, Christoph
Meindl, Alfons
Arnold, Norbert
Niederacher, Dieter
Deissler, Helmut
Spurdle, Amanda B
Chen, Xiaoqing
Waddell, Nicola
Cloonan, Nicole
Kirchhoff, Tomas
Offit, Kenneth
Friedman, Eitan
Kaufmann, Bella
Laitman, Yael
Galore, Gilli
Rennert, Gad
Lejbkowicz, Flavio
Raskin, Leon
Andrulis, Irene L
Ilyushik, Eduard
Ozcelik, Hilmi
Devilee, Peter
Vreeswijk, Maaike P G
Greene, Mark H
Prindiville, Sheila A
Osorio, Ana
Benitez, Javier
Zikan, Michal
Szabo, Csilla I
Kilpivaara, Outi
Nevanlinna, Heli
Hamann, Ute
Durocher, Francine
Arason, Adalgeir
Couch, Fergus J
Easton, Douglas F
Chenevix-Trench, Georgia
Show allShow less
Issue Date
2007-12-01

Metadata
Show full item record
Citation
Am. J. Hum. Genet. 2007, 81(6):1186-1200
Abstract
RAD51 is an important component of double-stranded DNA-repair mechanisms that interacts with both BRCA1 and BRCA2. A single-nucleotide polymorphism (SNP) in the 5' untranslated region (UTR) of RAD51, 135G-->C, has been suggested as a possible modifier of breast cancer risk in BRCA1 and BRCA2 mutation carriers. We pooled genotype data for 8,512 female mutation carriers from 19 studies for the RAD51 135G-->C SNP. We found evidence of an increased breast cancer risk in CC homozygotes (hazard ratio [HR] 1.92 [95% confidence interval {CI} 1.25-2.94) but not in heterozygotes (HR 0.95 [95% CI 0.83-1.07]; P=.002, by heterogeneity test with 2 degrees of freedom [df]). When BRCA1 and BRCA2 mutation carriers were analyzed separately, the increased risk was statistically significant only among BRCA2 mutation carriers, in whom we observed HRs of 1.17 (95% CI 0.91-1.51) among heterozygotes and 3.18 (95% CI 1.39-7.27) among rare homozygotes (P=.0007, by heterogeneity test with 2 df). In addition, we determined that the 135G-->C variant affects RAD51 splicing within the 5' UTR. Thus, 135G-->C may modify the risk of breast cancer in BRCA2 mutation carriers by altering the expression of RAD51. RAD51 is the first gene to be reliably identified as a modifier of risk among BRCA1/2 mutation carriers.
Description
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links
http://dx.doi.org/10.1086/522611
ae974a485f413a2113503eed53cd6c53
10.1086/522611
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers.
  • Authors: Levy-Lahad E, Lahad A, Eisenberg S, Dagan E, Paperna T, Kasinetz L, Catane R, Kaufman B, Beller U, Renbaum P, Gershoni-Baruch R
  • Issue date: 2001 Mar 13
  • RAD51 135G>C does not modify breast cancer risk in non-BRCA1/2 mutation carriers: evidence from a meta-analysis of 12 studies.
  • Authors: Yu KD, Yang C, Fan L, Chen AX, Shao ZM
  • Issue date: 2011 Apr
  • A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers.
  • Authors: Kadouri L, Kote-Jarai Z, Hubert A, Durocher F, Abeliovich D, Glaser B, Hamburger T, Eeles RA, Peretz T
  • Issue date: 2004 May 17
  • A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
  • Authors: Wang WW, Spurdle AB, Kolachana P, Bove B, Modan B, Ebbers SM, Suthers G, Tucker MA, Kaufman DJ, Doody MM, Tarone RE, Daly M, Levavi H, Pierce H, Chetrit A, Yechezkel GH, Chenevix-Trench G, Offit K, Godwin AK, Struewing JP
  • Issue date: 2001 Sep
  • RAD51 135G>C polymorphism and breast cancer risk: a meta-analysis.
  • Authors: Zhou GW, Hu J, Peng XD, Li Q
  • Issue date: 2011 Jan

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.