Effects of weight loss and seafood consumption on inflammation parameters in young, overweight and obese European men and women during 8 weeks of energy restriction
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationEur J Clin Nutr. 2010, 64(9):987-93
AbstractBackground/Objectives:In vitro studies have shown that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) can affect inflammation; however, results from intervention studies in overweight or obese individuals are contradicting. The aim of this study was to investigate the effects of weight loss and seafood consumption on inflammation parameters during energy restriction.Subjects/Methods:In this 8-week intervention trial, 324 subjects (aged 20-40 years, body mass index 27.5-32.5 kg/m(2) from Iceland, Spain and Ireland) were randomized to one of four energy-restricted diets (-30% relative to estimated requirements): salmon (3 x 150 g/week, 2.1 g LC n-3 PUFA per day); cod (3 x 150 g/week, 0.3 g LC n-3 PUFA per day); fish oil capsules (1.3 g LC n-3 PUFA per day); and control (sunflower oil capsules, no seafood). Body weight, high-sensitivity C-reactive protein (CRP), interleukin-6 (IL-6), glutathione reductase and prostaglandin F2 alpha (PGEF2alpha) were measured at baseline and end point.Results:Subjects experienced weight loss (-5.2+/-3.2 kg, P<0.001). Taken together for all subjects, there were significant decreases in all inflammation parameters. On a group level, salmon consumption was most effective, three of the four inflammation parameters decreased in the salmon group (high-sensitivity CRP=-32.0%; IL-6=-18.4%; PGEF2alpha=-18.5%; all P<0.05). Cod consumption decreased high-sensitivity CRP and IL-6 (-21.5 and -10.8%, respectively, both P<0.05). Changes in the other two groups were not significant, which can be partly explained by the large s.d.Conclusions:The mean concentrations of inflammation parameters decreased during a period of weight loss and dietary intervention. In our study, salmon consumption was most effective, three of the four measured inflammation parameters decreased significantly in the salmon group.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Moderate consumption of fatty fish reduces diastolic blood pressure in overweight and obese European young adults during energy restriction.
- Authors: Ramel A, Martinez JA, Kiely M, Bandarra NM, Thorsdottir I
- Issue date: 2010 Feb
- Consumption of cod and weight loss in young overweight and obese adults on an energy reduced diet for 8-weeks.
- Authors: Ramel A, Jonsdottir MT, Thorsdottir I
- Issue date: 2009 Dec
- Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults.
- Authors: Ramel A, Martinéz A, Kiely M, Morais G, Bandarra NM, Thorsdottir I
- Issue date: 2008 Jul
- Fish consumption among young overweight European adults and compliance to varying seafood content in four weight loss intervention diets.
- Authors: Thorsdottir I, Birgisdottir B, Kiely M, Martinez J, Bandarra N
- Issue date: 2009 May
- A diet rich in long chain omega-3 fatty acids modulates satiety in overweight and obese volunteers during weight loss.
- Authors: Parra D, Ramel A, Bandarra N, Kiely M, Martínez JA, Thorsdottir I
- Issue date: 2008 Nov