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dc.contributor.authorFallest-Strobl, P C
dc.contributor.authorOlafsdottir, E
dc.contributor.authorWiebe, D A
dc.contributor.authorWestgard, J O
dc.date.accessioned2010-09-15T11:09:18Z
dc.date.available2010-09-15T11:09:18Z
dc.date.issued1997-11-01
dc.date.submitted2010-09-15
dc.identifier.citationClin. Chem. 1997, 43(11):2164-8en
dc.identifier.issn0009-9147
dc.identifier.pmid9365403
dc.identifier.urihttp://hdl.handle.net/2336/111198
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe National Cholesterol Education Program (NCEP) performance specifications for methods that measure triglycerides, HDL-cholesterol, and LDL-cholesterol have been evaluated by deriving operating specifications from the NCEP analytical total error requirements and the clinical requirements for interpretation of the tests. We determined the maximum imprecision and inaccuracy that would be allowable to control routine methods with commonly used single and multirule quality-control procedures having 2 and 4 control measurements per run, and then compared these estimates with the NCEP guidelines. The NCEP imprecision specifications meet the operating imprecision necessary to assure meeting the NCEP clinical quality requirements for triglycerides and HDL-cholesterol but not for LDL-cholesterol. More importantly, the NCEP imprecision specifications are not adequate to assure meeting the NCEP analytical total error requirements for any of these three tests. Our findings indicate that the NCEP recommendations fail to adequately consider the quality-control requirements necessary to detect medically important systematic errors.
dc.language.isoenen
dc.publisherAmerican Association For Clinical Chemistryen
dc.relation.urlhttp://www.clinchem.org/cgi/content/abstract/43/11/2164en
dc.subject.meshCholesterol, HDLen
dc.subject.meshCholesterol, LDLen
dc.subject.meshHumansen
dc.subject.meshQuality Controlen
dc.subject.meshReference Standardsen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshTriglyceridesen
dc.subject.meshUnited Statesen
dc.titleComparison of NCEP performance specifications for triglycerides, HDL-, and LDL-cholesterol with operating specifications based on NCEP clinical and analytical goalsen
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53792, USA.en
dc.identifier.journalClinical chemistryen
html.description.abstractThe National Cholesterol Education Program (NCEP) performance specifications for methods that measure triglycerides, HDL-cholesterol, and LDL-cholesterol have been evaluated by deriving operating specifications from the NCEP analytical total error requirements and the clinical requirements for interpretation of the tests. We determined the maximum imprecision and inaccuracy that would be allowable to control routine methods with commonly used single and multirule quality-control procedures having 2 and 4 control measurements per run, and then compared these estimates with the NCEP guidelines. The NCEP imprecision specifications meet the operating imprecision necessary to assure meeting the NCEP clinical quality requirements for triglycerides and HDL-cholesterol but not for LDL-cholesterol. More importantly, the NCEP imprecision specifications are not adequate to assure meeting the NCEP analytical total error requirements for any of these three tests. Our findings indicate that the NCEP recommendations fail to adequately consider the quality-control requirements necessary to detect medically important systematic errors.


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