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dc.contributor.authorJohannsson, O T
dc.contributor.authorIdvall, I
dc.contributor.authorAnderson, C
dc.contributor.authorBorg, A
dc.contributor.authorBarkardottir, R B
dc.contributor.authorEgilsson, V
dc.contributor.authorOlsson, H
dc.date.accessioned2010-09-21T15:40:59Z
dc.date.available2010-09-21T15:40:59Z
dc.date.issued1997-03-01
dc.date.submitted2010-09-21
dc.identifier.citationEur. J. Cancer. 1997, 33(3):362-71en
dc.identifier.issn0959-8049
dc.identifier.pmid9155518
dc.identifier.urihttp://hdl.handle.net/2336/111569
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBRCA1 mutations, although implicated in disease predisposition in a major part of the hereditary breast cancer population, do not seem to be crucially involved in tumorigenesis of sporadic breast and ovarian cancers. This suggests that tumours arising in BRCA1 mutation carriers may differ from BRCA1 negative hereditary and sporadic cancer in genetic and biological features, as well as in clinical behaviour. Prior to BRCA1 analysis, 79 breast and 19 ovarian tumours from 57 breast and breast-ovarian cancer families, and 170 tumours from a comparison group of stage II breast cancers were studied with regard to histopathological features; immunohistochemistry [c-erbB-2, p53, oestrogen receptor (ER) and progesterone receptor (PR)], DNA flow cytometry and S-phase fraction. BRCA1 mutations were found in 40 breast and 15 ovarian tumours. The BRCA1 positive breast tumours were significantly more often of ductal type, histological grade III and manifested a heavy lymphocyte infiltration. Additionally, as compared to BRCA1 negative tumours, the BRCA1 positive tumours were significantly more often ER, PgR and c-erbB-2 negative. Furthermore, they were significantly more often DNA non-diploid, as well as being characterised by higher S-phase fraction values. These results suggest that BRCA1-induced breast cancers may manifest distinct tumour biological features of clinical importance.
dc.language.isoenen
dc.publisherElsevier BVen
dc.relation.urlhttp://dx.doi.org/10.1016/S0959-8049(97)89007-7en
dc.subject.meshAdulten
dc.subject.meshAge Distributionen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshBreast Neoplasmsen
dc.subject.meshFemaleen
dc.subject.meshFlow Cytometryen
dc.subject.meshGenes, BRCA1en
dc.subject.meshHumansen
dc.subject.meshImmunoenzyme Techniquesen
dc.subject.meshMiddle Ageden
dc.subject.meshMutationen
dc.subject.meshNeoplastic Syndromes, Hereditaryen
dc.subject.meshOvarian Neoplasmsen
dc.subject.meshTumor Markers, Biologicalen
dc.titleTumour biological features of BRCA1-induced breast and ovarian canceren
dc.typeArticleen
dc.contributor.departmentDepartment of Oncology, University Hospital, Lund, Sweden.en
dc.identifier.journalEuropean journal of cancer (Oxford, England : 1990)en
html.description.abstractBRCA1 mutations, although implicated in disease predisposition in a major part of the hereditary breast cancer population, do not seem to be crucially involved in tumorigenesis of sporadic breast and ovarian cancers. This suggests that tumours arising in BRCA1 mutation carriers may differ from BRCA1 negative hereditary and sporadic cancer in genetic and biological features, as well as in clinical behaviour. Prior to BRCA1 analysis, 79 breast and 19 ovarian tumours from 57 breast and breast-ovarian cancer families, and 170 tumours from a comparison group of stage II breast cancers were studied with regard to histopathological features; immunohistochemistry [c-erbB-2, p53, oestrogen receptor (ER) and progesterone receptor (PR)], DNA flow cytometry and S-phase fraction. BRCA1 mutations were found in 40 breast and 15 ovarian tumours. The BRCA1 positive breast tumours were significantly more often of ductal type, histological grade III and manifested a heavy lymphocyte infiltration. Additionally, as compared to BRCA1 negative tumours, the BRCA1 positive tumours were significantly more often ER, PgR and c-erbB-2 negative. Furthermore, they were significantly more often DNA non-diploid, as well as being characterised by higher S-phase fraction values. These results suggest that BRCA1-induced breast cancers may manifest distinct tumour biological features of clinical importance.


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