Possible locus for bipolar disorder near the dopamine transporter on chromosome 5
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsKelsoe, J R
Sadovnick, A D
Rapaport, M H
Spence, M A
Remick, R A
MetadataShow full item record
CitationAm. J. Med. Genet. 1996, 67(6):533-40
AbstractThe dopamine transporter (DAT) plays a key role in the regulation of dopaminergic neurotransmission by mediating the active reuptake of synaptic dopamine. It is an important candidate gene for bipolar disorder because of data implicating dopamine abnormalities in mania, and because it is the site of action of amphetamine, which has activating and psychotogenic properties. DAT has recently been cloned by its homology to a family of transporters, and mapped to chromosome 5p15.3. We tested DAT for linkage to bipolar disorder in a collection of 21 families from the general North American population (University of California, San Diego/University of British Columbia [UCSD/UBC] families), three Icelandic pedigrees, and Old Order Amish pedigree 110. We examined three markers at DAT, including a 5' TaqI RFLP (HDAT-TaqI), a highly polymorphic variable number of tandem repeats marker (VNTR) (HDAT-VNTR1), and a 3' 40-bp repeat marker (HDAT-PCR1), as well as two nearby microsatellite markers, D5S392 and D5S406. A maximum lod score of 2.38 was obtained at D5S392 in one of the UCSD/UBC families under an autosomal-dominant model. A lod score of 1.09 was also obtained under the same dominant model in the Amish at HDAT-PCR1. In the combined set of families, a maximum lod score of 1.76 was obtained under an autosomal-recessive model at HDAT-TaqI. Positive results were also obtained at several markers, using three nonparametric methods in the UCSD/UBC family set: the affected pedigree member method (P = 0.001), an affected sib pair method (ESPA, P = 0.0008), and the transmission disequilibrium test (P = 0.024). These results suggest the presence of a susceptibility locus for bipolar disorder near the DAT locus on chromosome 5.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Genetic linkage study of bipolar disorder and the serotonin transporter.
- Authors: Kelsoe JR, Remick RA, Sadovnick AD, Kristbjarnarson H, Flodman P, Spence MA, Morison M, Mroczkowski-Parker Z, Bergesch P, Rapaport MH, Mirow AL, Blakely RD, Helgason T, Egeland JA
- Issue date: 1996 Apr 9
- Bipolar disorder: dominant or recessive on chromosome 5?
- Authors: Homer JP, Flodman PL, Spence MA
- Issue date: 1997
- Serotonin transporter (5-HTT) gene and bipolar affective disorder.
- Authors: Esterling LE, Yoshikawa T, Turner G, Badner JA, Bengel D, Gershon ES, Berrettini WH, Detera-Wadleigh SD
- Issue date: 1998 Feb 7
- The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome.
- Authors: Gelernter J, Vandenbergh D, Kruger SD, Pauls DL, Kurlan R, Pakstis AJ, Kidd KK, Uhl G
- Issue date: 1995 Dec 10
- Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier.
- Authors: Kahlig KM, Javitch JA, Galli A
- Issue date: 2004 Mar 5