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High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients

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Authors
Johannesdottir, G
Gudmundsson, J
Bergthorsson, J T
Arason, A
Agnarsson, B A
Eiriksdottir, G
Johannsson, O T
Borg, A
Ingvarsson, S
Easton, D F
Egilsson, V
Barkardottir, R B
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Issue Date
1996-08-15

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Citation
Cancer Res. 1996, 56(16):3663-5
Abstract
Studies on Icelandic breast cancer families have shown that most of them segregate a 999del5 BRCA2 mutation. Here, we report the frequency of the 999del5 BRCA2 mutation in an Icelandic control population and four different groups of cancer patients diagnosed with (a) breast cancer; (b) ovarian cancer; (c) prostate cancer (patients younger than 65 years); and (d) other cancer types. The proportions of individuals carrying the mutation were 0.4% in the control population and in the patient groups 8.5%, 7.9%, 2.7%, and 1.0%, respectively. Our results indicate that BRCA2 confers a very high risk of breast cancer and is responsible for a substantial fraction of breast and ovarian cancer in Iceland, but only a small proportion of other cancers.
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http://cancerres.aacrjournals.org/content/56/16/3663.abstract
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English Journal Articles (Peer Reviewed)

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