• Quantitative Dual-Energy Computed Tomography Supports a Vascular Etiology of Smoking-induced Inflammatory Lung Disease.

      Iyer, Krishna S; Newell, John D; Jin, Dakai; Fuld, Matthew K; Saha, Punam K; Hansdottir, Sif; Hoffman, Eric A; [ 1 ] Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA [ 2 ] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA [ 3 ] Univ Iowa, Dept Elect Engn, Iowa City, IA 52242 USA [ 4 ] Univ Iowa, Dept Internal Med, Div Pulm Med, Iowa City, IA 52242 USA [ 5 ] Siemens Med Solut Inc, Malvern, PA USA [ 6 ] Landspitali Univ Hosp, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital (Amer Thoracic Soc, 2016-03-15)
      Endothelial dysfunction is of interest in relation to smoking-associated emphysema, a component of chronic obstructive pulmonary disease (COPD). We previously demonstrated that computed tomography (CT)-derived pulmonary blood flow (PBF) heterogeneity is greater in smokers with normal pulmonary function tests (PFTs) but who have visual evidence of centriacinar emphysema (CAE) on CT.