• Circulating sclerostin associated with vertebral bone marrow fat in older men but not women.

      Ma, Yu-Heng Vivian; Schwartz, Ann V; Sigurdsson, Sigurdur; Hue, Trisha F; Lang, Thomas F; Harris, Tamara B; Rosen, Clifford J; Vittinghoff, Eric; Eiriksdottir, Gudny; Hauksdottir, Alda M; et al. (Endocrine Society, 2014-12)
      Osteocyte activity is crucial to the maintenance of bone quality. Sclerostin, an osteocyte product, inhibits bone formation, yet higher circulating sclerostin is associated with higher bone density. Bone marrow fat (MF) is associated with osteoporosis, but little is known about the relationship between osteocyte activity and MF.