• Antiepileptic drugs are associated with central hypothyroidism.

      Einarsdottir, Margret Jona; Olafsson, Elias; Sigurjonsdottir, Helga Agusta; 1 Department of Medicine, Landspitali University Hospital, Reykjavík, Iceland. 2 Department of Neurology, Landspitali University Hospital, Reykjavik, Iceland. 3 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 4 Department of Endocrinology, Landspitali University Hospital, Reykjavik, Iceland. (Wiley, 2019-01-01)
      Studies in children have shown an increased frequency of central hypothyroidism (CH) with long-term use of antiepileptic drugs (AEDs). The aim of this study was to search for CH in adults treated with AEDs and find whether the type of AEDs used matters. Adult epileptic patients treated at the neurology outpatient clinic at Landspitali University Hospital (LSH) from 1998 to 2011 were included. Patients were invited for a blood test if serum levels for TSH (s-TSH) or free-T We identified 165 patients (92 women), mean age 45.6 (±15.5, range: 20-92) years. The mean s-fT 21% of patients treated with AEDs had CH, more often patients taking carbamazepine or oxacarbazepine, and more often women. The s-fT