Recent Submissions

  • Anaplastic thyroid carcinoma transformation in a lateral neck node metastasis - A case report and a review of the literature

    Gunnarsdottir, Agnes B; Briem, Birgir A; Jonasson, Larus; Tryggvason, Geir; [ 1 ] Skanes Univ Sjukhus Lund, Dept Otolaryngol & Head & Neck Canc, Lund, Sweden Show more [ 2 ] Landspitali Univ Hosp, Dept Otolaryngol Head & Neck Surg, IS-108 Reykjavik, Iceland Show more [ 3 ] Landspitali Univ Hosp, Dept Surg Pathol, Reykjavik, Iceland (Taylor & Francis, 2018)
    Anaplastic thyroid carcinoma is thought to be derived from previous existing papillary or follicular thyroid carcinoma that dedifferentiates into its anaplastic counterpart. We present a case where this type of dedifferentiation occurs at a metastatic site in a regional lymph node, years after the primary papillary thyroid tumor had metastasized.
  • Towards an Individualized Nutrition Treatment: Role of the Gastrointestinal Microbiome in the Interplay Between Diet and Obesity.

    Adalsteinsdottir, Solveig A; Magnusdottir, Ola K; Halldorsson, Thorhallur I; Birgisdottir, Bryndis E; 1 Unit for Nutrition Research, Faculty of Food Science and Nutrition, Landspitali University Hospital, University of Iceland, Eiriksgata 29, 101, Reykjavik, Iceland. 2 Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, DK-2300, Copenhagen, Denmark. 3 Unit for Nutrition Research, Faculty of Food Science and Nutrition, Landspitali University Hospital, University of Iceland, Eiriksgata 29, 101, Reykjavik, Iceland. (Springer, 2018-12-01)
    Dietary treatments for obesity have relatively low long-term success. Recent studies have identified the gastrointestinal microbiome as a factor of high relevance. The current knowledge on the interplay between diet, obesity, and the gastrointestinal microbiome and the potential for individualized dietary treatment will be discussed. Studies indicate that each individual digests and metabolizes identical food substances differently depending on their gastrointestinal microbiome composition. Factors related to this crosstalk may improve our understanding of weight homeostasis and treatment of obesity. Long-time dietary intake is the key in the composition of the gastrointestinal microbiome which seems to be an important factor for energy balance, resulting in emerging opportunities for increasingly varied obesity treatment. Compliance to dietary treatment is critical for long-term success as enduring changes in gastrointestinal microbiome seem to slow over time. More research is urgently needed to investigate this missing link in our understanding of obesity.
  • Giant gastric lipoma successfully removed by endoscopic submucosal dissection: case report and systematic review.

    Ingason, Arnar B; Theodors, Asgeir; Agustsson, Arnar S; Arnarson, Adalsteinn; 1 a Department of Medicine , University of Iceland , Reykjavik , Iceland. 2 b Department of Gastroenterology , Landspitali University Hospital , Reykjavik , Iceland. 3 c Department of General Surgery , Landspitali University Hospital , Reykjavik , Iceland. (Taylor & Francis, 2018-08-01)
    Gastric lipomas are rare adipose tumors that constitute less than 1% of gastric tumors. While lipomas generally do not need removal unless symptomatic, endoscopic resection has been proposed as safe for gastric lipomas smaller than 2 cm. Yet, there is no consensus on the optimal treatment method for larger lipomas. We report a case of a giant 7-cm gastric lipoma successfully removed by endoscopic submucosal dissection (ESD) and systematically review the literature for gastric lipomas removed by ESD. Systematic review was conducted by searching PubMed and Scopus databases, up to 15 February 2018, using combinations of relevant terms. We report a 55-year-old male with known gastroesophageal reflux disease and asthma, who sought medical attention due to chronic heartburn and asthma exacerbations. These symptoms were attributed to a large 7 cm × 3 cm gastric lipoma that caused gastric outlet obstruction. The lipoma was safely removed by ESD, allowing quick recovery and alleviation of symptoms. In our review, we identified 20 gastric lipomas treated with ESD, with 15 (75%) being 2 cm or larger. The average size of the lipomas was 4 cm (range: 1.2-9 cm). All lipomas were limited to the submucosa, with 80% of the tumors located in the antrum. Three lipomas were removed by submucosal tunneling. All tumors were successfully removed en bloc and no major complications were reported. Our findings support the conclusion that ESD may be a safe alternative to conventional surgery for removal of large symptomatic gastric lipomas.
  • Editor's Choice - The Impact of Centralisation and Endovascular Aneurysm Repair on Treatment of Ruptured Abdominal Aortic Aneurysms Based on International Registries.

    Budtz-Lilly, Jacob; Björck, Martin; Venermo, Maarit; Debus, Sebastian; Behrendt, Christian-Alexander; Altreuther, Martin; Beiles, Barry; Szeberin, Zoltan; Eldrup, Nikolaj; Danielsson, Gudmundur; Thomson, Ian; Wigger, Pius; Khashram, Manar; Loftus, Ian; Mani, Kevin; 1 Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden; Department of Cardio-Thoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark. Electronic address: 2 Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden. 3 Department of Vascular Surgery, Helsinki University Hospital, Helsinki, Finland. 4 Department of Vascular Medicine, University Heart Centre Hamburg - Eppendorf, Hamburg, Germany. 5 Department of Vascular Surgery, St Olavs Hospital, Trondheim, Norway. 6 Australian and New Zealand Society for Vascular Surgery, East Melbourne, Australia. 7 Department of Vascular Surgery, Semmelweis University, Budapest, Hungary. 8 Department of Cardio-Thoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark. 9 National University Hospital of Iceland, Department of Surgery, Reykjavík, Iceland. 10 Department of Vascular Surgery, Dunedin School of Medicine, Dunedin Hospital, Dunedin, New Zealand. 11 Department of Cardiovascular Surgery, Kantonsspital Winterthur, Switzerland. 12 Department of Surgery, University of Otago, Christchurch, New Zealand. 13 Department of Vascular Surgery, St George's University of London, London, UK. (W.B. Saunders, 2018-08-01)
    Current management of ruptured abdominal aortic aneurysms (RAAA) varies among centres and countries, particularly in the degree of implementation of endovascular aneurysm repair (EVAR) and levels of vascular surgery centralisation. This study assesses these variations and the impact they have on outcomes. RAAA repairs from vascular surgical registries in 11 countries, 2010-2013, were investigated. Data were analysed overall, per country, per treatment modality (EVAR or open aortic repair [OAR]), centre volume (quintiles IV), and whether centres were predominantly EVAR (≥50% of RAAA performed with EVAR [EVAR(p)]) or predominantly OAR [OAR(p)]. Primary outcome was peri-operative mortality. Data are presented as either mean values or percentages with 95% CI within parentheses, and compared with chi-square tests, as well as with adjusted OR. There were 9273 patients included. Mean age was 74.7 (74.5-74.9) years, and 82.7% of patients were men (81.9-83.6). Mean AAA diameter at rupture was 7.6 cm (7.5-7.6). Of these aneurysms, 10.7% (10.0-11.4) were less than 5.5 cm. EVAR was performed in 23.1% (22.3-24.0). There were 6817 procedures performed in OAR(p) centres and 1217 performed in EVAR(p) centres. Overall peri-operative mortality was 28.8% (27.9-29.8). Peri-operative mortality for OAR was 32.1% (31.0-33.2) and for EVAR 17.9% (16.3-19.6), p < .001, and the adjusted OR was 0.38 (0.31-0.47), p < .001. The peri-operative mortality was 23.0% in EVAR(p) centres (20.6-25.4), 29.7% in OAR(p) centres (28.6-30.8), p < .001; adjusted OR = 0.60 (0.46-0.78), p < .001. Peri-operative mortality was lower in the highest volume centres (QI > 22 repairs per year), 23.3% (21.2-25.4) than in QII-V, 30.0% (28.9-31.1), p < .001. Peri-operative mortality after OAR was lower in high volume centres compared with the other centres, 25.3% (23.0-27.6) and 34.0% (32.7-35.4), respectively, p < .001. There was no significant difference in peri-operative mortality after EVAR between centres based on volume. Peri-operative mortality is lower in centres with a primary EVAR approach or with high case volume. Most repairs, however, are still performed in low volume centres and in centres with a primary OAR strategy. Reorganisation of acute vascular surgical services may improve outcomes of RAAA repair.
  • Dramatically improved survival in multiple myeloma patients in the recent decade: results from a Swedish population-based study.

    Thorsteinsdottir, Sigrun; Dickman, Paul W; Landgren, Ola; Blimark, Cecilie; Hultcrantz, Malin; Turesson, Ingemar; Björkholm, Magnus; Kristinsson, Sigurdur Y; 1 Department of Internal Medicine, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. 2 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 3 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 4 Myeloma Service, Division of Hematologic Oncology, Memorial Sloan-Kettering Cancer Center, NY, USA. 5 Department of Internal Medicine, Hematology Section, Sahlgrenska University Hospital, Gothenburg, Sweden. 6 Department of Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. 7 Department of Hematology and Coagulation Disorders, Skane University Hospital, Malmo, Sweden. 8 Department of Internal Medicine, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland (Ferrata Storti Foundation, 2018-09-01)
  • Adrenergic and metabolic effects of electrical weapons: review and meta-analysis of human data.

    Kunz, S N; Calkins, H G; Adamec, J; Kroll, M W; [ 1 ] Landspitali Univ Hosp, Dept Forens Pathol, IS-101 Reykjavik, Iceland Show more [ 2 ] Johns Hopkins Med Inst, Baltimore, MD 21205 USA Show more [ 3 ] Ludwig Maximilians Univ Munchen, Inst Forens Med, Munich, Germany Show more [ 4 ] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN USA Show more [ 5 ] Calif Polytech Inst, San Luis Obispo, CA USA (Springer, 2018-09-01)
    Electronic control with the CEW (conducted electrical weapon) has gained widespread acceptance as the preferred force option due to its significant injury reduction. However, a CEW application does stress the human body. In the case of the CEW, the human body response is similar to the challenge of physical exercise combined with emotional stress over a very short time interval. There has been concern whether the tension of the skeletal-muscle system together with the emotional stress of being exposed to the effects of a CEW, can lead to severe metabolic dysfunction. A systematic and careful search of the MedLine database was performed to find publications describing pathophysiological effects of CEWs. Additional publications were collected through a manual search of reference lists in retrieved articles. After preliminary exclusions, we carefully reviewed the remaining publications and found 24 papers reporting prospective human clinical research data on adrenergic, ventilation, or metabolic effects. Where there were multiple studies on the same endpoints, we performed meta-analyses. A CEW exposure provides a clinically insignificant increase in heart rate (7.5 BPM) and a drop in both systolic and diastolic blood pressure. Alpha-amylase goes down but cortisol levels increase-both epinephrine and norepinephrine levels are increased by levels similar to mild exercise. A CEW exposure increases ventilation but does not appear to interfere with gas exchange. Lactate is increased slightly while the pH is decreased slightly with changes equivalent to mild exercise. The lactate and pH changes appear quickly and do not appear to be affected by increasing the exposure duration from 5 to 30 s. Thorough review and meta-analyses show that electrical weapon exposures have mixed and mild adrenergic effects. Ventilation is increased and there are metabolic changes similar to mild exercise.
  • Cardiac and skeletal muscle effects of electrical weapons : A review of human and animal studies.

    Kunz, Sebastian N; Calkins, Hugh; Adamec, Jiri; Kroll, Mark W; [ 1 ] Landspitali Univ Hosp, Dept Forens Pathol, V Baronstig 101, Reykjavik, Iceland Show more [ 2 ] Univ Iceland, Reykjavik, Iceland Show more [ 3 ] Johns Hopkins Med Inst, Baltimore, MD 21205 USA Show more [ 4 ] Ludwig Maximilians Univ Munchen, Inst Forens Med, Munich, Germany Show more [ 5 ] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN USA Show more [ 6 ] Calif Polytech Inst, San Luis Obispo, CA USA (Humana Press, 2018-09-01)
    Conducted Electrical Weapons (CEWs) are being used as the preferred non-lethal force option for police and special forces worldwide. This new technology challenges an exposed opponent similarly to the way they would be challenged by physical exercise combined with emotional stress. While adrenergic and metabolic effects have been meta-analyzed and reviewed, there has been no systematic review of the effects of CEWs on skeletal and cardiac muscle. A systematic and careful search of the MedLine database was performed to find publications describing pathophysiological cardiac and skeletal muscle effects of CEWs. For skeletal muscle effects, we analyzed all publications providing changes in creatine kinase, myoglobin and potassium. For cardiac effects, we analyzed reported troponin changes and arrhythmias related to short dart-to-heart-distances. Conducted electrical weapons satisfy all relevant electrical safety standards and there are, to date, no proven electrocution incidents caused by CEWs. A potential cardiovascular risk has been recognized by some of the experimental animal data. The effects on the heart appear to be limited to instances when there is a short dart-to-heart-distance. The effect on the skeletal muscle system appears to be negligible. A responsible use of a CEW on a healthy adult, within the guidelines proposed by the manufacturer, does not imply a significant health risk for that healthy adult.
  • Corrigendum to "Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency" [J. Chromatogr. B 1036-1037 (2016) 170-177].

    Thorsteinsdottir, Margret; Thorsteinsdottir, Unnur A; Eiriksson, Finnur F; Runolfsdottir, Hrafnhildur L; Agustsdottir, Inger M Sch; Oddsdottir, Steinunn; Sigurdsson, Baldur B; Hardarson, Hordur K; Kamble, Nilesh R; Sigurdsson, Snorri Th; Edvardsson, Vidar O; Palsson, Runolfur; [ 1 ] Univ Iceland, Reykjavik, Iceland [ 2 ] ArcticMass, Reykjavik, Iceland [ 3 ] Landspitali Natl Univ Hosp Iceland, Childrens Med Ctr, Reykjavik, Iceland [ 4 ] Landspitali Natl Univ Hosp Iceland, Dept Clin Biochem, Reykjavik, Iceland Show more [ 5 ] European Acad Bolzano Bozen, Ctr Biomed, Bolzano, Italy [ 6 ] Landspitali Natl Univ Hosp Iceland, Div Nephrol, Reykjavik, Iceland (Elsevier Science, 2018-08-15)
  • Inflammatory Breast Cancer: What surgeons need to know.

    Rafnsdóttir, Svanheiður Lóa; Audisio, Riccardo A; 1 Oncoplastic Breast Surgery, Department of Surgery, Landspitali University Hospital, 13-A Hringbraut, IS-101, Reykjavik, Iceland; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Blå Stråket 5, 413 45, Göteborg, Sweden. Electronic address: 2 Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Blå Stråket 5, 413 45, Göteborg, Sweden. Electronic address: (Elsevier, 2018-01-01)
    Strict criteria to identify Inflammatory Breast Cancer (IBC) have been made available - these are based on pathological as well as clinical observations. It is mandatory to confirm the criteria used in any further report. Scientific evidence accumulated so far is confusing, and unclear therefore no hard conclusion can be drawn from the available literature on the management of IBC. The advent of new medications results into an up-to-date management and different outcomes. It is mandatory to follow these criteria if reliable guidelines are to be made available in the next future.
  • A Case of Complete Scotoma Following Intake of Conjugated Linoleic Acid Supplement

    Eliasson, Jon H.; Birgisdottir, Bryndis E.; Gudmundsson, Larus S.; 1 ] Centralsjukhuset, Dept Neurol, Kristianstad, Sweden Show more [ 2 ] Univ Iceland, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland Show more [ 3 ] Landspitali Univ Hosp, Reykjavik, Iceland Show more [ 4 ] Univ Iceland, Fac Pharmaceut Sci, Hagi Hofsvallagata 53, IS-107 Reykjavik, Iceland; Department of Neurology; Centralsjukhuset; Kristianstad Sweden; Unit for Nutrition Research; Faculty of Food Science and Nutrition University of Iceland and Landspitali University Hospital; Reykjavik Iceland; Faculty of Pharmaceutical Sciences; University of Iceland; Reykjavik Iceland (Wiley, 2018-05)
  • Port-site Metastases After Robot-assisted Radical Cystectomy: Is There a Publication Bias?

    Jancke, Georg; Aljabery, Firas; Gudjonsson, Sigurdur; Hosseini, Abolfazl; Sörenby, Anne; Wiklund, Peter; Liedberg, Fredrik; [ 1 ] Skane Univ Hosp, Dept Urol, Jan Waldenstroms Gata 7, SE-20502 Malmo, Sweden Show more [ 2 ] Lund Univ, Dept Translat Med, Malmo, Sweden Show more [ 3 ] Linkoping Univ Hosp, Dept Urol, Linkoping, Sweden Show more [ 4 ] Landspitali Univ Hosp, Dept Urol, Reykjavik, Iceland Show more [ 5 ] Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden (Elsevier Science, 2018-04)
  • Self-reported exposure to traffic pollution in relation to daytime sleepiness and habitual snoring: a questionnaire study in seven North-European cities.

    Gislason, Thorarinn; Bertelsen, Randi J; Real, Francisco Gomez; Sigsgaard, Torben; Franklin, Karl A; Lindberg, Eva; Janson, Christer; Arnardottir, Erna Sif; Hellgren, Johan; Benediktsdottir, Bryndis; Forsberg, Bertil; Johannessen, Ane; 1Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Respiratory Medicine and Sleep, Landspitali - National University Hospital of Iceland, Iceland. 2Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Institute of Clinical Medicine, University of Bergen, Bergen, Norway. 3Institute of Clinical Medicine, University of Bergen, Bergen, Norway. 4Department of Public Health, Aarhus University, Aarhus, Denmark. 5Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. 6Department of Medical Sciences, Respiratory-, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden. 7Institute of Clinical Science, University of Gothenburg, Sweden; Department of Otorhinolaryngology, Head & Neck Surgery, Sahlgrenska Academy, Gothenburg, Sweden. 8Department of Public Health and Clinical Medicine/Occupational & Environmental Medicine, Umeå University, Umeå, Sweden. 9Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (Elsevier Science, 2016-08)
    Daytime sleepiness is associated with traffic pollution and traffic noise, while habitual snoring is only associated with traffic noise. Self-reported traffic exposure should be taken into account when diagnosing and planning treatment for patients with sleep disturbances, because reducing noise and pollution exposure in the bedroom may have a beneficial effect.
  • Decreased postural control in adult survivors of childhood cancer treated with chemotherapy.

    Einarsson, Einar-Jón; Patel, Mitesh; Petersen, Hannes; Wiebe, Thomas; Fransson, Per-Anders; Magnusson, Måns; Moëll, Christian; Department of Clinical Sciences, Lund University, Lund, Sweden. 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 3Division of Brain Sciences, Imperial College London, London, United Kingdom. 4Department of Otorhinolaryngology, Landspitali University Hospital, Reykjavik, Iceland. 5Department of Paediatrics, Skåne University Hospital, Lund, Sweden. 6Department of Otorhinolaryngology, Skåne University Hospital, Lund, Sweden. (Nature Publishing Group, 2016-11-10)
    The objective of cancer treatment is to secure survival. However, as chemotherapeutic agents can affect the central and peripheral nervous systems, patients must undergo a process of central compensation. We explored the effectiveness of this compensation process by measuring postural behaviour in adult survivors of childhood cancer treated with chemotherapy (CTS). We recruited sixteen adults treated with chemotherapy in childhood for malignant solid (non-CNS) tumours and 25 healthy age-matched controls. Subjects performed posturography with eyes open and closed during quiet and perturbed standing. Repeated balance perturbations through calf vibrations were used to study postural adaptation. Subjects were stratified into two groups (treatment before or from 12 years of age) to determine age at treatment effects. Both quiet (p = 0.040) and perturbed standing (p ≤ 0.009) were significantly poorer in CTS compared to controls, particularly with eyes open and among those treated younger. Moreover, CTS had reduced levels of adaptation compared to controls, both with eyes closed and open. Hence, adults treated with chemotherapy for childhood cancer may suffer late effects of poorer postural control manifested as reduced contribution of vision and as reduced adaptation skills. These findings advocate development of chemotherapeutic agents that cause fewer long-term side effects when used for treating children.
  • Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome.

    Claesson, J; Freundlich, M; Gunnarsson, I; Laake, J H; M?ller, M H; Vandvik, P O; Varpula, T; Aasmundstad, T A; [ 1 ] Umea Univ, Anaesthesiol & Intens Care Med, Umea, Sweden [ 2 ] Univ Hosp Umea, Umea, Sweden [ 3 ] Aalborg Univ Hosp, Anaesthesiol, Aalborg, Denmark [ 4 ] Landspitali Univ Hosp, Anaesthesiol & Intens Care Med, Reykjavik, Iceland ??Organization-Enhanced Name(s) ???? Landspitali National University Hospital [ 5 ] Oslo Univ Hosp, Div Crit Care, Anaesthesiol, Oslo, Norway [ 6 ] Rigshosp, Copenhagen Univ Hosp, Intens Care 4131, Copenhagen, Denmark [ 7 ] Innlandet Hosp Trust Div Gjovik, Med, Gjovik, Norway [ 8 ] Norwegian Knowledge Ctr Hlth Serv, Oslo, Norway [ 9 ] Helsinki Univ Hosp, Intens Care Med, Helsinki, Finland (Wiley-Blackwell, 2016-07)
    This guideline emphasizes the paucity of evidence of benefit - and potential for harm - of common interventions in adults with ARDS and highlights the need for prudence when considering use of non-licensed interventions in this patient population.
  • Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort.

    Bertelsen, Birgitte; Stefánsson, Hreinn; Riff Jensen, Lars; Melchior, Linea; Mol Debes, Nanette; Groth, Camilla; Skov, Liselotte; Werge, Thomas; Karagiannidis, Iordanis; Tarnok, Zsanett; Barta, Csaba; Nagy, Peter; Farkas, Luca; Brøndum-Nielsen, Karen; Rizzo, Renata; Gulisano, Mariangela; Rujescu, Dan; Kiemeney, Lambertus A; Tosato, Sarah; Nawaz, Muhammad Sulaman; Ingason, Andres; Unnsteinsdottir, Unnur; Steinberg, Stacy; Ludvigsson, Pétur; Stefansson, Kari; Kuss, Andreas Walter; Paschou, Peristera; Cath, Danielle; Hoekstra, Pieter J; Müller-Vahl, Kirsten; Stuhrmann, Manfred; Silahtaroglu, Asli; Pfundt, Rolph; Tümer, Zeynep; [ 1 ] Rigshosp, Copenhagen Univ Hosp, Kennedy Ctr, Appl Human Mol Genet,Dept Clin Genet, Glostrup, Denmark [ 2 ] deCODE Genet, Reykjavik, Iceland [ 3 ] Univ Med Greifswald, Dept Human Genet, Greifswald, Germany [ 4 ] Ernst Moritz Arndt Univ Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany [ 5 ] Herlev Hosp, Dept Pediat, Tourette Clin, DK-2730 Herlev, Denmark [ 6 ] Capital Reg Denmark, Mental Hlth Serv, Sct Hans, Inst Biol Psychiat,Mental Hlth Ctr, Hillerod, Denmark [ 7 ] Univ Copenhagen, Fac Med & Hlth Sci, Inst Clin Sci, Copenhagen, Denmark [ 8 ] IPSYCH, Initiat Integrat Psychiat Res, Roskilde, Denmark [ 9 ] Democritus Univ Thrace, Dept Mol Biol & Genet, Alexandroupolis, Greece [ 10 ] Vadaskert Child & Adolescent Psychiat Clin, Budapest, Hungary [ 11 ] Semmelweis Univ, Mol Biol & Pathobiochem, Dept Med Chem, H-1085 Budapest, Hungary [ 12 ] Catania Univ, Dept Med & Pediat Sci, Sect Child Neuropsychiat, Catania, Italy [ 13 ] Univ Halle Wittenberg, Dept Psychiat, Psychotherapy & Psychosomat, D-06108 Halle, Germany [ 14 ] Radboud Univ Nijmegen, Med Ctr, Dept Hlth Evidence, NL-6525 ED Nijmegen, Netherlands [ 15 ] Univ Verona, Sect Psychiat, Dept Publ Hlth & Community Med, I-37100 Verona, Italy [ 16 ] Landspitalinn Univ Hosp, Dept Pediat, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 17 ] Univ Utrecht, Dept Clin & Hlth Psychol, Utrecht, Netherlands [ 18 ] Altrecht Acad Anxiety Outpatient Clin, Utrecht, Netherlands [ 19 ] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands [ 20 ] Hannover Med Sch, Psychiat Clin, Social Psychiat & Psychotherapy, Hannover, Germany [ 21 ] Hannover Med Sch, Inst Human Genet, Hannover, Germany [ 22 ] Univ Copenhagen, Dept Cellular & Mol Med, Wilhelm Johansen Ctr Funct Genome Res, Copenhagen, Denmark [ 23 ] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands (Elsevier Science Inc, 2016-03-01)
    AADAC is a candidate susceptibility factor for GTS and the present findings warrant further genomic and functional studies to investigate the role of this gene in the pathogenesis of GTS.
  • Association between healthy maternal dietary pattern and risk for gestational diabetes mellitus.

    Tryggvadottir, E A; Medek, H; Birgisdottir, B E; Geirsson, R T; Gunnarsdottir, I; [ 1 ] Univ Iceland, Landspitali Natl Univ Hosp, Unit Nutr Res, Eiriksgata 28, IS-101 Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital     University of Iceland [ 2 ] Univ Iceland, Fac Food Sci & Nutr, Eiriksgata 28, IS-101 Reykjavik, Iceland [ 3 ] Univ Iceland, Landspitali Univ Hosp, Womens Clin, Dept Obstet & Gynecol, Eiriksgata 28, IS-101 Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital     University of Iceland (Nature Publishing Group, 2016-02)
    Adhering to a prudent dietary pattern in pregnancy was clearly associated with lower risk of GDM, especially among women already at higher risk because of overweight/obesity before pregnancy.
  • Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients.

    Krag, Mette; Perner, Anders; Wetterslev, Jørn; Wise, Matt P; Borthwick, Mark; Bendel, Stepani; McArthur, Colin; Cook, Deborah; Nielsen, Niklas; Pelosi, Paolo; Keus, Frederik; Guttormsen, Anne Berit; Moller, Alma D; Møller, Morten Hylander; [ 1 ] Rigshosp, Dept Intens Care 4131, Copenhagen Univ Hosp, DK-2100 Copenhagen, Denmark [ 2 ] Rigshosp, Ctr Clin Intervent Res, Copenhagen Univ Hosp, Copenhagen Trial Unit, DK-2100 Copenhagen, Denmark [ 3 ] Univ Wales Hosp, Dept Adult Crit Care, Cardiff CF4 4XW, S Glam, Wales [ 4 ] Oxford Univ Hosp NHS Trust, Dept Pharm, Oxford, England [ 5 ] Kuopio Univ Hosp, Dept Intens Care Med, SF-70210 Kuopio, Finland [ 6 ] Auckland City Hosp, Dept Crit Care Med, Auckland, New Zealand [ 7 ] McMaster Univ, Dept Med, Hamilton, ON, Canada [ 8 ] Helsingborg Hosp, Dept Anaesthesiol & Intens Care, Helsingborg, Sweden [ 9 ] Lund Univ, Dept Clin Sci, Lund, Sweden [ 10 ] Univ Genoa, IRCCS San Martino IST, Dept Surg Sci & Integrated Diagnost, Genoa, Italy [ 11 ] Univ Groningen, Univ Med Ctr Groningen, Dept Crit Care, Groningen, Netherlands [ 12 ] Haukeland Hosp, Dept Anaesthesia & Intens Care, N-5021 Bergen, Norway [ 13 ] Clin Inst 1 UiB, Bergen, Norway [ 14 ] Landspitali Univ Hosp Reykjavik, Dept Anaesthesia & Intens Care, Reykjavik, Iceland (Springer, 2015-05)
    In ICU patients clinically important GI bleeding is rare, and acid suppressants are frequently used. Co-existing diseases, liver failure, coagulopathy and organ failures are the main risk factors for GI bleeding. Clinically important GI bleeding was not associated with increased adjusted 90-day mortality, which largely can be explained by severity of comorbidity, other organ failures and age.
  • A total population-based cohort study of female psychiatric inpatients who have served a prison sentence.

    Steingrimsson, Steinn; Sigurdsson, Martin I; Gudmundsdottir, Hafdis; Aspelund, Thor; Magnusson, Andres; Department of Psychiatry, Landspitali University Hospital, Reykjavik, Iceland; Centre of Ethics, Law and Mental Health (CELAM), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. (Whurr Publishers Ltd., 2015-03-31)
    Women admitted to a psychiatric hospital have higher rates of imprisonment than the general population. Because admission predated imprisonment in most cases, this may be seen as an opportunity for early intervention to reduce later criminality. Copyright © 2015 John Wiley & Sons, Ltd.
  • One-way endobronchial valve for bronchopleural fistula after necrotizing pneumonia.

    Gudbjartsson, Tomas; Helgadottir, Solveig; Ek, Lars (Chen Yuan, Republic of Singapore : Asia Pub. EXchange,, 2013-08)
  • Treatment for high-risk smoldering myeloma.

    Kristinsson, Sigurdur Y; Holmberg, Erik; Blimark, Cecilie; Univ Iceland, Reykjavik, Iceland, Univ Gothenburg, Gothenburg, Sweden (Massachusetts Medical Society, 2013-10-31)

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