Recent Submissions

  • Cardiac and skeletal muscle effects of electrical weapons : A review of human and animal studies.

    Kunz, Sebastian N; Calkins, Hugh; Adamec, Jiri; Kroll, Mark W; [ 1 ] Landspitali Univ Hosp, Dept Forens Pathol, V Baronstig 101, Reykjavik, Iceland Show more [ 2 ] Univ Iceland, Reykjavik, Iceland Show more [ 3 ] Johns Hopkins Med Inst, Baltimore, MD 21205 USA Show more [ 4 ] Ludwig Maximilians Univ Munchen, Inst Forens Med, Munich, Germany Show more [ 5 ] Univ Minnesota, Dept Biomed Engn, Minneapolis, MN USA Show more [ 6 ] Calif Polytech Inst, San Luis Obispo, CA USA (Humana Press, 2018-09-01)
    Conducted Electrical Weapons (CEWs) are being used as the preferred non-lethal force option for police and special forces worldwide. This new technology challenges an exposed opponent similarly to the way they would be challenged by physical exercise combined with emotional stress. While adrenergic and metabolic effects have been meta-analyzed and reviewed, there has been no systematic review of the effects of CEWs on skeletal and cardiac muscle. A systematic and careful search of the MedLine database was performed to find publications describing pathophysiological cardiac and skeletal muscle effects of CEWs. For skeletal muscle effects, we analyzed all publications providing changes in creatine kinase, myoglobin and potassium. For cardiac effects, we analyzed reported troponin changes and arrhythmias related to short dart-to-heart-distances. Conducted electrical weapons satisfy all relevant electrical safety standards and there are, to date, no proven electrocution incidents caused by CEWs. A potential cardiovascular risk has been recognized by some of the experimental animal data. The effects on the heart appear to be limited to instances when there is a short dart-to-heart-distance. The effect on the skeletal muscle system appears to be negligible. A responsible use of a CEW on a healthy adult, within the guidelines proposed by the manufacturer, does not imply a significant health risk for that healthy adult.
  • Corrigendum to "Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency" [J. Chromatogr. B 1036-1037 (2016) 170-177].

    Thorsteinsdottir, Margret; Thorsteinsdottir, Unnur A; Eiriksson, Finnur F; Runolfsdottir, Hrafnhildur L; Agustsdottir, Inger M Sch; Oddsdottir, Steinunn; Sigurdsson, Baldur B; Hardarson, Hordur K; Kamble, Nilesh R; Sigurdsson, Snorri Th; Edvardsson, Vidar O; Palsson, Runolfur; [ 1 ] Univ Iceland, Reykjavik, Iceland [ 2 ] ArcticMass, Reykjavik, Iceland [ 3 ] Landspitali Natl Univ Hosp Iceland, Childrens Med Ctr, Reykjavik, Iceland [ 4 ] Landspitali Natl Univ Hosp Iceland, Dept Clin Biochem, Reykjavik, Iceland Show more [ 5 ] European Acad Bolzano Bozen, Ctr Biomed, Bolzano, Italy [ 6 ] Landspitali Natl Univ Hosp Iceland, Div Nephrol, Reykjavik, Iceland (Elsevier Science, 2018-08-15)
  • Inflammatory Breast Cancer: What surgeons need to know.

    Rafnsdóttir, Svanheiður Lóa; Audisio, Riccardo A; 1 Oncoplastic Breast Surgery, Department of Surgery, Landspitali University Hospital, 13-A Hringbraut, IS-101, Reykjavik, Iceland; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Blå Stråket 5, 413 45, Göteborg, Sweden. Electronic address: svanhra@landspitali.is. 2 Department of Surgery, Institute of Clinical Sciences, Sahlgrenska University Hospital, Blå Stråket 5, 413 45, Göteborg, Sweden. Electronic address: raudisio@doctors.org.uk. (Elsevier, 2018-01-01)
    Strict criteria to identify Inflammatory Breast Cancer (IBC) have been made available - these are based on pathological as well as clinical observations. It is mandatory to confirm the criteria used in any further report. Scientific evidence accumulated so far is confusing, and unclear therefore no hard conclusion can be drawn from the available literature on the management of IBC. The advent of new medications results into an up-to-date management and different outcomes. It is mandatory to follow these criteria if reliable guidelines are to be made available in the next future.
  • A Case of Complete Scotoma Following Intake of Conjugated Linoleic Acid Supplement

    Eliasson, Jon H.; Birgisdottir, Bryndis E.; Gudmundsson, Larus S.; 1 ] Centralsjukhuset, Dept Neurol, Kristianstad, Sweden Show more [ 2 ] Univ Iceland, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland Show more [ 3 ] Landspitali Univ Hosp, Reykjavik, Iceland Show more [ 4 ] Univ Iceland, Fac Pharmaceut Sci, Hagi Hofsvallagata 53, IS-107 Reykjavik, Iceland; Department of Neurology; Centralsjukhuset; Kristianstad Sweden; Unit for Nutrition Research; Faculty of Food Science and Nutrition University of Iceland and Landspitali University Hospital; Reykjavik Iceland; Faculty of Pharmaceutical Sciences; University of Iceland; Reykjavik Iceland (Wiley, 2018-05)
  • Port-site Metastases After Robot-assisted Radical Cystectomy: Is There a Publication Bias?

    Jancke, Georg; Aljabery, Firas; Gudjonsson, Sigurdur; Hosseini, Abolfazl; Sörenby, Anne; Wiklund, Peter; Liedberg, Fredrik; [ 1 ] Skane Univ Hosp, Dept Urol, Jan Waldenstroms Gata 7, SE-20502 Malmo, Sweden Show more [ 2 ] Lund Univ, Dept Translat Med, Malmo, Sweden Show more [ 3 ] Linkoping Univ Hosp, Dept Urol, Linkoping, Sweden Show more [ 4 ] Landspitali Univ Hosp, Dept Urol, Reykjavik, Iceland Show more [ 5 ] Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden (Elsevier Science, 2018-04)
  • Self-reported exposure to traffic pollution in relation to daytime sleepiness and habitual snoring: a questionnaire study in seven North-European cities.

    Gislason, Thorarinn; Bertelsen, Randi J; Real, Francisco Gomez; Sigsgaard, Torben; Franklin, Karl A; Lindberg, Eva; Janson, Christer; Arnardottir, Erna Sif; Hellgren, Johan; Benediktsdottir, Bryndis; Forsberg, Bertil; Johannessen, Ane; 1Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Respiratory Medicine and Sleep, Landspitali - National University Hospital of Iceland, Iceland. 2Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Institute of Clinical Medicine, University of Bergen, Bergen, Norway. 3Institute of Clinical Medicine, University of Bergen, Bergen, Norway. 4Department of Public Health, Aarhus University, Aarhus, Denmark. 5Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. 6Department of Medical Sciences, Respiratory-, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden. 7Institute of Clinical Science, University of Gothenburg, Sweden; Department of Otorhinolaryngology, Head & Neck Surgery, Sahlgrenska Academy, Gothenburg, Sweden. 8Department of Public Health and Clinical Medicine/Occupational & Environmental Medicine, Umeå University, Umeå, Sweden. 9Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (Elsevier Science, 2016-08)
    Daytime sleepiness is associated with traffic pollution and traffic noise, while habitual snoring is only associated with traffic noise. Self-reported traffic exposure should be taken into account when diagnosing and planning treatment for patients with sleep disturbances, because reducing noise and pollution exposure in the bedroom may have a beneficial effect.
  • Decreased postural control in adult survivors of childhood cancer treated with chemotherapy.

    Einarsson, Einar-Jón; Patel, Mitesh; Petersen, Hannes; Wiebe, Thomas; Fransson, Per-Anders; Magnusson, Måns; Moëll, Christian; Department of Clinical Sciences, Lund University, Lund, Sweden. 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 3Division of Brain Sciences, Imperial College London, London, United Kingdom. 4Department of Otorhinolaryngology, Landspitali University Hospital, Reykjavik, Iceland. 5Department of Paediatrics, Skåne University Hospital, Lund, Sweden. 6Department of Otorhinolaryngology, Skåne University Hospital, Lund, Sweden. (Nature Publishing Group, 2016-11-10)
    The objective of cancer treatment is to secure survival. However, as chemotherapeutic agents can affect the central and peripheral nervous systems, patients must undergo a process of central compensation. We explored the effectiveness of this compensation process by measuring postural behaviour in adult survivors of childhood cancer treated with chemotherapy (CTS). We recruited sixteen adults treated with chemotherapy in childhood for malignant solid (non-CNS) tumours and 25 healthy age-matched controls. Subjects performed posturography with eyes open and closed during quiet and perturbed standing. Repeated balance perturbations through calf vibrations were used to study postural adaptation. Subjects were stratified into two groups (treatment before or from 12 years of age) to determine age at treatment effects. Both quiet (p = 0.040) and perturbed standing (p ≤ 0.009) were significantly poorer in CTS compared to controls, particularly with eyes open and among those treated younger. Moreover, CTS had reduced levels of adaptation compared to controls, both with eyes closed and open. Hence, adults treated with chemotherapy for childhood cancer may suffer late effects of poorer postural control manifested as reduced contribution of vision and as reduced adaptation skills. These findings advocate development of chemotherapeutic agents that cause fewer long-term side effects when used for treating children.
  • Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome.

    Claesson, J; Freundlich, M; Gunnarsson, I; Laake, J H; M?ller, M H; Vandvik, P O; Varpula, T; Aasmundstad, T A; [ 1 ] Umea Univ, Anaesthesiol & Intens Care Med, Umea, Sweden [ 2 ] Univ Hosp Umea, Umea, Sweden [ 3 ] Aalborg Univ Hosp, Anaesthesiol, Aalborg, Denmark [ 4 ] Landspitali Univ Hosp, Anaesthesiol & Intens Care Med, Reykjavik, Iceland ??Organization-Enhanced Name(s) ???? Landspitali National University Hospital [ 5 ] Oslo Univ Hosp, Div Crit Care, Anaesthesiol, Oslo, Norway [ 6 ] Rigshosp, Copenhagen Univ Hosp, Intens Care 4131, Copenhagen, Denmark [ 7 ] Innlandet Hosp Trust Div Gjovik, Med, Gjovik, Norway [ 8 ] Norwegian Knowledge Ctr Hlth Serv, Oslo, Norway [ 9 ] Helsinki Univ Hosp, Intens Care Med, Helsinki, Finland (Wiley-Blackwell, 2016-07)
    This guideline emphasizes the paucity of evidence of benefit - and potential for harm - of common interventions in adults with ARDS and highlights the need for prudence when considering use of non-licensed interventions in this patient population.
  • Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort.

    Bertelsen, Birgitte; Stefánsson, Hreinn; Riff Jensen, Lars; Melchior, Linea; Mol Debes, Nanette; Groth, Camilla; Skov, Liselotte; Werge, Thomas; Karagiannidis, Iordanis; Tarnok, Zsanett; Barta, Csaba; Nagy, Peter; Farkas, Luca; Brøndum-Nielsen, Karen; Rizzo, Renata; Gulisano, Mariangela; Rujescu, Dan; Kiemeney, Lambertus A; Tosato, Sarah; Nawaz, Muhammad Sulaman; Ingason, Andres; Unnsteinsdottir, Unnur; Steinberg, Stacy; Ludvigsson, Pétur; Stefansson, Kari; Kuss, Andreas Walter; Paschou, Peristera; Cath, Danielle; Hoekstra, Pieter J; Müller-Vahl, Kirsten; Stuhrmann, Manfred; Silahtaroglu, Asli; Pfundt, Rolph; Tümer, Zeynep; [ 1 ] Rigshosp, Copenhagen Univ Hosp, Kennedy Ctr, Appl Human Mol Genet,Dept Clin Genet, Glostrup, Denmark [ 2 ] deCODE Genet, Reykjavik, Iceland [ 3 ] Univ Med Greifswald, Dept Human Genet, Greifswald, Germany [ 4 ] Ernst Moritz Arndt Univ Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany [ 5 ] Herlev Hosp, Dept Pediat, Tourette Clin, DK-2730 Herlev, Denmark [ 6 ] Capital Reg Denmark, Mental Hlth Serv, Sct Hans, Inst Biol Psychiat,Mental Hlth Ctr, Hillerod, Denmark [ 7 ] Univ Copenhagen, Fac Med & Hlth Sci, Inst Clin Sci, Copenhagen, Denmark [ 8 ] IPSYCH, Initiat Integrat Psychiat Res, Roskilde, Denmark [ 9 ] Democritus Univ Thrace, Dept Mol Biol & Genet, Alexandroupolis, Greece [ 10 ] Vadaskert Child & Adolescent Psychiat Clin, Budapest, Hungary [ 11 ] Semmelweis Univ, Mol Biol & Pathobiochem, Dept Med Chem, H-1085 Budapest, Hungary [ 12 ] Catania Univ, Dept Med & Pediat Sci, Sect Child Neuropsychiat, Catania, Italy [ 13 ] Univ Halle Wittenberg, Dept Psychiat, Psychotherapy & Psychosomat, D-06108 Halle, Germany [ 14 ] Radboud Univ Nijmegen, Med Ctr, Dept Hlth Evidence, NL-6525 ED Nijmegen, Netherlands [ 15 ] Univ Verona, Sect Psychiat, Dept Publ Hlth & Community Med, I-37100 Verona, Italy [ 16 ] Landspitalinn Univ Hosp, Dept Pediat, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 17 ] Univ Utrecht, Dept Clin & Hlth Psychol, Utrecht, Netherlands [ 18 ] Altrecht Acad Anxiety Outpatient Clin, Utrecht, Netherlands [ 19 ] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands [ 20 ] Hannover Med Sch, Psychiat Clin, Social Psychiat & Psychotherapy, Hannover, Germany [ 21 ] Hannover Med Sch, Inst Human Genet, Hannover, Germany [ 22 ] Univ Copenhagen, Dept Cellular & Mol Med, Wilhelm Johansen Ctr Funct Genome Res, Copenhagen, Denmark [ 23 ] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands (Elsevier Science Inc, 2016-03-01)
    AADAC is a candidate susceptibility factor for GTS and the present findings warrant further genomic and functional studies to investigate the role of this gene in the pathogenesis of GTS.
  • Association between healthy maternal dietary pattern and risk for gestational diabetes mellitus.

    Tryggvadottir, E A; Medek, H; Birgisdottir, B E; Geirsson, R T; Gunnarsdottir, I; [ 1 ] Univ Iceland, Landspitali Natl Univ Hosp, Unit Nutr Res, Eiriksgata 28, IS-101 Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital     University of Iceland [ 2 ] Univ Iceland, Fac Food Sci & Nutr, Eiriksgata 28, IS-101 Reykjavik, Iceland [ 3 ] Univ Iceland, Landspitali Univ Hosp, Womens Clin, Dept Obstet & Gynecol, Eiriksgata 28, IS-101 Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital     University of Iceland (Nature Publishing Group, 2016-02)
    Adhering to a prudent dietary pattern in pregnancy was clearly associated with lower risk of GDM, especially among women already at higher risk because of overweight/obesity before pregnancy.
  • Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients.

    Krag, Mette; Perner, Anders; Wetterslev, Jørn; Wise, Matt P; Borthwick, Mark; Bendel, Stepani; McArthur, Colin; Cook, Deborah; Nielsen, Niklas; Pelosi, Paolo; Keus, Frederik; Guttormsen, Anne Berit; Moller, Alma D; Møller, Morten Hylander; [ 1 ] Rigshosp, Dept Intens Care 4131, Copenhagen Univ Hosp, DK-2100 Copenhagen, Denmark [ 2 ] Rigshosp, Ctr Clin Intervent Res, Copenhagen Univ Hosp, Copenhagen Trial Unit, DK-2100 Copenhagen, Denmark [ 3 ] Univ Wales Hosp, Dept Adult Crit Care, Cardiff CF4 4XW, S Glam, Wales [ 4 ] Oxford Univ Hosp NHS Trust, Dept Pharm, Oxford, England [ 5 ] Kuopio Univ Hosp, Dept Intens Care Med, SF-70210 Kuopio, Finland [ 6 ] Auckland City Hosp, Dept Crit Care Med, Auckland, New Zealand [ 7 ] McMaster Univ, Dept Med, Hamilton, ON, Canada [ 8 ] Helsingborg Hosp, Dept Anaesthesiol & Intens Care, Helsingborg, Sweden [ 9 ] Lund Univ, Dept Clin Sci, Lund, Sweden [ 10 ] Univ Genoa, IRCCS San Martino IST, Dept Surg Sci & Integrated Diagnost, Genoa, Italy [ 11 ] Univ Groningen, Univ Med Ctr Groningen, Dept Crit Care, Groningen, Netherlands [ 12 ] Haukeland Hosp, Dept Anaesthesia & Intens Care, N-5021 Bergen, Norway [ 13 ] Clin Inst 1 UiB, Bergen, Norway [ 14 ] Landspitali Univ Hosp Reykjavik, Dept Anaesthesia & Intens Care, Reykjavik, Iceland (Springer, 2015-05)
    In ICU patients clinically important GI bleeding is rare, and acid suppressants are frequently used. Co-existing diseases, liver failure, coagulopathy and organ failures are the main risk factors for GI bleeding. Clinically important GI bleeding was not associated with increased adjusted 90-day mortality, which largely can be explained by severity of comorbidity, other organ failures and age.
  • A total population-based cohort study of female psychiatric inpatients who have served a prison sentence.

    Steingrimsson, Steinn; Sigurdsson, Martin I; Gudmundsdottir, Hafdis; Aspelund, Thor; Magnusson, Andres; Department of Psychiatry, Landspitali University Hospital, Reykjavik, Iceland; Centre of Ethics, Law and Mental Health (CELAM), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. (Whurr Publishers Ltd., 2015-03-31)
    Women admitted to a psychiatric hospital have higher rates of imprisonment than the general population. Because admission predated imprisonment in most cases, this may be seen as an opportunity for early intervention to reduce later criminality. Copyright © 2015 John Wiley & Sons, Ltd.
  • One-way endobronchial valve for bronchopleural fistula after necrotizing pneumonia.

    Gudbjartsson, Tomas; Helgadottir, Solveig; Ek, Lars (Chen Yuan, Republic of Singapore : Asia Pub. EXchange,, 2013-08)
  • Treatment for high-risk smoldering myeloma.

    Kristinsson, Sigurdur Y; Holmberg, Erik; Blimark, Cecilie; Univ Iceland, Reykjavik, Iceland, Univ Gothenburg, Gothenburg, Sweden (Massachusetts Medical Society, 2013-10-31)
  • Að efla heilbrigði: Næringarráðgjöf sem íhlutun fyrir of þungar konur fyrir og eftir fæðingu

    Helga Gottfreðsdóttir; Inga Þórsdóttir; Hjúkrunarfræðideild Háskóli Íslands, Heilbrigðisvísindasvið, Háskóli Íslands og Landspítala (Ljósmæðrafélag Íslands, 2012)
    Nýjustu tölur um líkamsþyngd Íslendingasýna að tæplega 59% fólks á aldrinum 18–80ára er yfir kjörþyngd og þar af flokkast 21%með offitu. Rannsóknir benda til að hlutfallþeirra sem eru of feitir fari vaxandi. Konur ábarneignaraldri fara ekki varhluta af þessariþróun en niðurstöður fjölda rannsóknahafa sýnt tengsl offitu við ýmis vandamál ogsjúkdóma tengdum meðgöngu og fæðingu.Í þessari grein er varpað ljósi á þá stöðusem ríkir hér á landi varðandi yfirþyngd ogofþyngd kvenna á meðgöngu og afleiðingarþess en rannsóknir sýna að konur á barnsburðaraldri18–39 ára eru of þungar í 41%tilvika og þar af eru 18% of feitar. Nokkrarerlendar rannsóknir hafa sýnt fram á að meðþví að nota hvatningaviðtöl, næringarráðgjöfog upplýsingar um hreyfingu megi hafa áhrif áþyngdaraukningu kvenna á meðgöngu. Flestaríhlutunarrannsóknir eru þó með litlu úrtaki ogí fáum þeirra er konum fylgt eftir að fæðingulokinni.Mikilvægt er að horfa á offitu semviðfangsefni þar sem fjöldi þátta hefur áhrif.Í öllum tilfellum þarf að huga að mataræðiog næringu konunnar og næringarráðgjöfsem felur í sér hvatningu og kennslu er þvínauðsynleg. Þá þarf að virkja eiginleika ífari hvers einstaklings til að sem hagstæðustútkoma fáist fyrir móður og barn. Í greininnikynnum við hugmyndafræði sem nota má viðþróun íhlutana fyrir konur á meðgöngu sembyggir á því að nota styrkleika hverrar ogeinnar konu samfara því að veita fræðslu ográðgjöf á einstaklingsbundinn hátt .
  • Thromboprophylaxis in multiple myeloma: is the evidence there?

    Kristinsson, Sigurdur Yngvi; Landgren, Ola (2012)
  • Family history of venous thromboembolism is associated with increased risk for thrombosis in multiple myeloma: a population-based study.

    Kristinsson, S Y; Goldin, L; Turesson, I; Hultcrantz, M; Björkholm, M; Landgren, O (Wiley-Blackwell, 2012-05)
  • Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts.

    Knevel, R; de Rooy, D P; Gregersen, P K; Lindqvist, E; Wilson, A G; Gröndal, G; Zhernakova, A; van Nies, J A; Toes, R E; Tsonaka, R; Houwing-Duistermaat, J J; Steinsson, K; Huizinga, T W; Saxne, T; van der Helm-van Mil, A H (2012-10)
  • The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

    Foxler, Daniel E; Bridge, Katherine S; James, Victoria; Webb, Thomas M; Mee, Maureen; Wong, Sybil C K; Feng, Yunfeng; Constantin-Teodosiu, Dumitru; Petursdottir, Thorgunnur Eyfjord; Bjornsson, Johannes; Ingvarsson, Sigurdur; Ratcliffe, Peter J; Longmore, Gregory D; Sharp, Tyson V; School of Biomedical Sciences, University of Nottingham, Queen's Medical Centre, NG7 2UH, UK. (2012-02)
    There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2) tension (normoxia) the PHDs hydroxylate two conserved proline residues on HIF-1α, which leads to binding of the von Hippel-Lindau (VHL) tumour suppressor, the recognition component of a ubiquitin-ligase complex, initiating HIF-1α ubiquitylation and degradation. However, it is not known whether PHDs and VHL act separately to exert their enzymatic activities on HIF-1α or as a multiprotein complex. Here we show that the tumour suppressor protein LIMD1 (LIM domain-containing protein) acts as a molecular scaffold, simultaneously binding the PHDs and VHL, thereby assembling a PHD-LIMD1-VHL protein complex and creating an enzymatic niche that enables efficient degradation of HIF-1α. Depletion of endogenous LIMD1 increases HIF-1α levels and transcriptional activity in both normoxia and hypoxia. Conversely, LIMD1 expression downregulates HIF-1 transcriptional activity in a manner depending on PHD and 26S proteasome activities. LIMD1 family member proteins Ajuba and WTIP also bind to VHL and PHDs 1 and 3, indicating that these LIM domain-containing proteins represent a previously unrecognized group of hypoxic regulators.
  • Ichthyosis prematurity syndrome with separation of fetal membranes and neonatal asphyxia.

    Dereksson, Kristjan; Kjartansson, Sveinn; Hjartardóttir, Hulda; Arngrimsson, Reynir; Pediatrics Department, Skåne University Hospital, Malmö, Sweden. (2012)
    Ichthyosis prematurity syndrome (IPS) is a rare inherited skin disorder. Children are born prematurely with thick skin and have been found to develop neonatal asphyxia due to occlusions in the bronchial tree from debris in the amniotic fluid. At 31 weeks of gestation, separation of amniotic and chorionic membranes was identified as well as polyhydramnion. The child was born 2 weeks later, with thickened skin with a granular appearance and required immediate ventilation and intensive care. At 2 years of age, the patient has developed an atopic skin condition with severe itching, recurrent skin infections, food intolerance and periods of wheezing. Prenatal observation of separation of foetal membranes or dense amniotic fluid may be signs of IPS and severe complication immediately after birth.

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