• Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort.

      Bertelsen, Birgitte; Stefánsson, Hreinn; Riff Jensen, Lars; Melchior, Linea; Mol Debes, Nanette; Groth, Camilla; Skov, Liselotte; Werge, Thomas; Karagiannidis, Iordanis; Tarnok, Zsanett; Barta, Csaba; Nagy, Peter; Farkas, Luca; Brøndum-Nielsen, Karen; Rizzo, Renata; Gulisano, Mariangela; Rujescu, Dan; Kiemeney, Lambertus A; Tosato, Sarah; Nawaz, Muhammad Sulaman; Ingason, Andres; Unnsteinsdottir, Unnur; Steinberg, Stacy; Ludvigsson, Pétur; Stefansson, Kari; Kuss, Andreas Walter; Paschou, Peristera; Cath, Danielle; Hoekstra, Pieter J; Müller-Vahl, Kirsten; Stuhrmann, Manfred; Silahtaroglu, Asli; Pfundt, Rolph; Tümer, Zeynep; [ 1 ] Rigshosp, Copenhagen Univ Hosp, Kennedy Ctr, Appl Human Mol Genet,Dept Clin Genet, Glostrup, Denmark [ 2 ] deCODE Genet, Reykjavik, Iceland [ 3 ] Univ Med Greifswald, Dept Human Genet, Greifswald, Germany [ 4 ] Ernst Moritz Arndt Univ Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany [ 5 ] Herlev Hosp, Dept Pediat, Tourette Clin, DK-2730 Herlev, Denmark [ 6 ] Capital Reg Denmark, Mental Hlth Serv, Sct Hans, Inst Biol Psychiat,Mental Hlth Ctr, Hillerod, Denmark [ 7 ] Univ Copenhagen, Fac Med & Hlth Sci, Inst Clin Sci, Copenhagen, Denmark [ 8 ] IPSYCH, Initiat Integrat Psychiat Res, Roskilde, Denmark [ 9 ] Democritus Univ Thrace, Dept Mol Biol & Genet, Alexandroupolis, Greece [ 10 ] Vadaskert Child & Adolescent Psychiat Clin, Budapest, Hungary [ 11 ] Semmelweis Univ, Mol Biol & Pathobiochem, Dept Med Chem, H-1085 Budapest, Hungary [ 12 ] Catania Univ, Dept Med & Pediat Sci, Sect Child Neuropsychiat, Catania, Italy [ 13 ] Univ Halle Wittenberg, Dept Psychiat, Psychotherapy & Psychosomat, D-06108 Halle, Germany [ 14 ] Radboud Univ Nijmegen, Med Ctr, Dept Hlth Evidence, NL-6525 ED Nijmegen, Netherlands [ 15 ] Univ Verona, Sect Psychiat, Dept Publ Hlth & Community Med, I-37100 Verona, Italy [ 16 ] Landspitalinn Univ Hosp, Dept Pediat, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 17 ] Univ Utrecht, Dept Clin & Hlth Psychol, Utrecht, Netherlands [ 18 ] Altrecht Acad Anxiety Outpatient Clin, Utrecht, Netherlands [ 19 ] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands [ 20 ] Hannover Med Sch, Psychiat Clin, Social Psychiat & Psychotherapy, Hannover, Germany [ 21 ] Hannover Med Sch, Inst Human Genet, Hannover, Germany [ 22 ] Univ Copenhagen, Dept Cellular & Mol Med, Wilhelm Johansen Ctr Funct Genome Res, Copenhagen, Denmark [ 23 ] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands (Elsevier Science Inc, 2016-03-01)
      Gilles de la Tourette syndrome (GTS) is a complex neuropsychiatric disorder with a strong genetic influence where copy number variations are suggested to play a role in disease pathogenesis. In a previous small-scale copy number variation study of a GTS cohort (n = 111), recurrent exon-affecting microdeletions of four genes, including the gene encoding arylacetamide deacetylase (AADAC), were observed and merited further investigations.