• Borrelia and subsequent risk of solid tumors and hematologic malignancies in Sweden.

      Chang, Cindy M; Landgren, Ola; Koshiol, Jill; Björkholm, Magnus; Löve, Thorvardur J; Kristinsson, Sigurdur Y; Landspitali University Hospital (2012-11-01)
    • Bronchiovenous fistula causing bleeding and air embolism: an unusual complication of bronchoscopic tumor resection.

      Sigurdsson, Martin I; Sigurdsson, Hjortur; Hreinsson, Kari; Simonardottir, Liney; Gudbjartsson, Tomas (American Thoracic Society, 2011-03-01)
    • Family history of venous thromboembolism is associated with increased risk for thrombosis in multiple myeloma: a population-based study.

      Kristinsson, S Y; Goldin, L; Turesson, I; Hultcrantz, M; Björkholm, M; Landgren, O (Wiley-Blackwell, 2012-05)
    • Ichthyosis prematurity syndrome with separation of fetal membranes and neonatal asphyxia.

      Dereksson, Kristjan; Kjartansson, Sveinn; Hjartardóttir, Hulda; Arngrimsson, Reynir; Pediatrics Department, Skåne University Hospital, Malmö, Sweden. (2012)
      Ichthyosis prematurity syndrome (IPS) is a rare inherited skin disorder. Children are born prematurely with thick skin and have been found to develop neonatal asphyxia due to occlusions in the bronchial tree from debris in the amniotic fluid. At 31 weeks of gestation, separation of amniotic and chorionic membranes was identified as well as polyhydramnion. The child was born 2 weeks later, with thickened skin with a granular appearance and required immediate ventilation and intensive care. At 2 years of age, the patient has developed an atopic skin condition with severe itching, recurrent skin infections, food intolerance and periods of wheezing. Prenatal observation of separation of foetal membranes or dense amniotic fluid may be signs of IPS and severe complication immediately after birth.
    • The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

      Foxler, Daniel E; Bridge, Katherine S; James, Victoria; Webb, Thomas M; Mee, Maureen; Wong, Sybil C K; Feng, Yunfeng; Constantin-Teodosiu, Dumitru; Petursdottir, Thorgunnur Eyfjord; Bjornsson, Johannes; et al. (2012-02)
      There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2) tension (normoxia) the PHDs hydroxylate two conserved proline residues on HIF-1α, which leads to binding of the von Hippel-Lindau (VHL) tumour suppressor, the recognition component of a ubiquitin-ligase complex, initiating HIF-1α ubiquitylation and degradation. However, it is not known whether PHDs and VHL act separately to exert their enzymatic activities on HIF-1α or as a multiprotein complex. Here we show that the tumour suppressor protein LIMD1 (LIM domain-containing protein) acts as a molecular scaffold, simultaneously binding the PHDs and VHL, thereby assembling a PHD-LIMD1-VHL protein complex and creating an enzymatic niche that enables efficient degradation of HIF-1α. Depletion of endogenous LIMD1 increases HIF-1α levels and transcriptional activity in both normoxia and hypoxia. Conversely, LIMD1 expression downregulates HIF-1 transcriptional activity in a manner depending on PHD and 26S proteasome activities. LIMD1 family member proteins Ajuba and WTIP also bind to VHL and PHDs 1 and 3, indicating that these LIM domain-containing proteins represent a previously unrecognized group of hypoxic regulators.
    • Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts.

      Knevel, R; de Rooy, D P; Gregersen, P K; Lindqvist, E; Wilson, A G; Gröndal, G; Zhernakova, A; van Nies, J A; Toes, R E; Tsonaka, R; et al. (2012-10)
    • Thromboprophylaxis in multiple myeloma: is the evidence there?

      Kristinsson, Sigurdur Yngvi; Landgren, Ola (2012)
    • Treatment for high-risk smoldering myeloma.

      Kristinsson, Sigurdur Y; Holmberg, Erik; Blimark, Cecilie; Univ Iceland, Reykjavik, Iceland, Univ Gothenburg, Gothenburg, Sweden (Massachusetts Medical Society, 2013-10-31)