• The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

      Foxler, Daniel E; Bridge, Katherine S; James, Victoria; Webb, Thomas M; Mee, Maureen; Wong, Sybil C K; Feng, Yunfeng; Constantin-Teodosiu, Dumitru; Petursdottir, Thorgunnur Eyfjord; Bjornsson, Johannes; et al. (2012-02)
      There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2) tension (normoxia) the PHDs hydroxylate two conserved proline residues on HIF-1α, which leads to binding of the von Hippel-Lindau (VHL) tumour suppressor, the recognition component of a ubiquitin-ligase complex, initiating HIF-1α ubiquitylation and degradation. However, it is not known whether PHDs and VHL act separately to exert their enzymatic activities on HIF-1α or as a multiprotein complex. Here we show that the tumour suppressor protein LIMD1 (LIM domain-containing protein) acts as a molecular scaffold, simultaneously binding the PHDs and VHL, thereby assembling a PHD-LIMD1-VHL protein complex and creating an enzymatic niche that enables efficient degradation of HIF-1α. Depletion of endogenous LIMD1 increases HIF-1α levels and transcriptional activity in both normoxia and hypoxia. Conversely, LIMD1 expression downregulates HIF-1 transcriptional activity in a manner depending on PHD and 26S proteasome activities. LIMD1 family member proteins Ajuba and WTIP also bind to VHL and PHDs 1 and 3, indicating that these LIM domain-containing proteins represent a previously unrecognized group of hypoxic regulators.
    • Long-term Outcome of Implantable Cardioverter/Defibrillator Lead Failure.

      Davidsson, Gustav Arnar; Jonsdottir, Gudlaug M; Oddsson, Hjortur; Lund, Sigrun H; Arnar, David O; 1Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 2Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. (American Medical Association, 2019-12-20)
      This study compares outcomes of a recalled implantable cardioverter/defibrillator lead with a control lead in individuals in Iceland.
    • Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort.

      Mendel, Arielle; Bernatsky, Sasha B; Hanly, John G; Urowitz, Murray B; Clarke, Ann Elaine; Romero-Diaz, Juanita; Gordon, Caroline; Bae, Sang-Cheol; Wallace, Daniel J; Merrill, Joan T; et al. (BMJ Publishing Group, 2019-07)
    • No One Will be Safe Until Our Children are Safe: Parent's Attitude Towards COVID-19 Childhood Immunization.

      Haraldsson, Ásgeir; Love, Thorvardur J; Thors, Valtyr Stefansson; 1Children's Hospital Iceland, Landspitali University Hospital, Iceland, University of Iceland, Faculty of Medicine, Reykjavík, Iceland. 2University of Iceland, Faculty of Medicine, Reykjavík, Iceland, Landspitali University Hospital, Iceland. 3Children's Hospital Iceland, Landspitali University Hospital, Iceland, Faculty of Medicine, University of Iceland, Reykjavík, Iceland. (Williams & Wilkins, 2021-10)
    • No transmission of SARS-CoV-2 to 23 healthcare professionals involved in advanced life support of COVID-19 patient - association with low viral RNA in respiratory specimens.

      Ingason, Arnar B; Jóhannesson, Jón M; Halldórsson, Jón T; Júlíusson, Unnsteinn I; Halldórsdóttir, Áslaug; Böðvarsson, Ásgeir; 1Husavik Hospital and Health Care Center, Husavik, Iceland. 2University of Iceland, Faculty of Medicine, Iceland. 3Department of Internal Medicine, Landspitali University Hospital, Iceland. 4Akureyri Primary Health Care Center, Akureyri, Iceland. (Taylor & Francis, 2020-08-21)
    • One-way endobronchial valve for bronchopleural fistula after necrotizing pneumonia.

      Gudbjartsson, Tomas; Helgadottir, Solveig; Ek, Lars (Chen Yuan, Republic of Singapore : Asia Pub. EXchange,, 2013-08)
    • Port-site Metastases After Robot-assisted Radical Cystectomy: Is There a Publication Bias?

      Jancke, Georg; Aljabery, Firas; Gudjonsson, Sigurdur; Hosseini, Abolfazl; Sörenby, Anne; Wiklund, Peter; Liedberg, Fredrik; [ 1 ] Skane Univ Hosp, Dept Urol, Jan Waldenstroms Gata 7, SE-20502 Malmo, Sweden Show more [ 2 ] Lund Univ, Dept Translat Med, Malmo, Sweden Show more [ 3 ] Linkoping Univ Hosp, Dept Urol, Linkoping, Sweden Show more [ 4 ] Landspitali Univ Hosp, Dept Urol, Reykjavik, Iceland Show more [ 5 ] Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden (Elsevier Science, 2018-04)
    • Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients.

      Krag, Mette; Perner, Anders; Wetterslev, Jørn; Wise, Matt P; Borthwick, Mark; Bendel, Stepani; McArthur, Colin; Cook, Deborah; Nielsen, Niklas; Pelosi, Paolo; et al. (Springer, 2015-05)
      To describe the prevalence of, risk factors for, and prognostic importance of gastrointestinal (GI) bleeding and use of acid suppressants in acutely ill adult intensive care patients.
    • The Process of Writing When English is Your Second Language

      Svavarsdottir, Erla Kolbrún; Faculty of Nursing, School of Health Sciences, University of Iceland (UI) and at Landspitali University Hospital (LUH) (Wiley-Blackwell, 2016-10)
    • Reply to "Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines".

      Veronese, Nicola; Petrovic, Mirko; Benetos, Athanase; Denkinger, Michael; Gudmundsson, Adalsteinn; Knol, Wilma; Marking, Christine; Soulis, George; Maggi, Stefania; Cherubini, Antonio; et al. (Elsevier, 2021-10-17)
    • Reply to Amit Bansal, Ruchir Maheshwari, and Anant Kumar's Letter to the Editor re: Fredrik Liedberg, Petter Kollberg, Marie Allerbo, et al. Preventing Parastomal Hernia After Ileal Conduit by the Use of a Prophylactic Mesh: A Randomised Study. Eur Urol 2020;78:757-63.

      Liedberg, Fredrik; Kollberg, Petter; Allerbo, Marie; Baseckas, Gediminas; Brändstedt, Johan; Gudjonsson, Sigurdur; Hagberg, Oskar; Håkansson, Ulf; Jerlström, Tomas; Löfgren, Annica; et al. (Elsevier, 2020-12-31)
    • Reply to Deepansh Dalela, Isaac Palma-Zamora, and Craig Rogers' Letter to the Editor re: Fredrick Leidberg, Petter Kollberg, Marie Allerbo, et al. Preventing Parastomal Hernia After Ileal Conduit by the Use of a Prophylactic Mesh: A Randomised Study. Eur Urol 2020;78:757-63.

      Liedberg, Fredrik; Kollberg, Petter; Allerbo, Marie; Baseckas, Gediminas; Brändstedt, Johan; Gudjonsson, Sigurdur; Hagberg, Oskar; Håkansson, Ulf; Jerlström, Tomas; Löfgren, Annica; et al. (Elsevier, 2021-01-25)
    • Reply to: Metformin use and keratinocyte carcinoma risk.

      Adalsteinsson, Jonas A; Waldman, Reid; Ratner, Désirée; Feng, Hao; Tryggvadottir, Laufey; Jonasson, Jon Gunnlaugur; 1Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Dermatology, University of Connecticut, Farmington, Connecticut. Electronic address: adalsteinsson@uchc.edu. 2Department of Dermatology, University of Connecticut, Farmington, Connecticut. 3Department of Dermatology, New York University Langone Health, New York, New York. 4Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Cancer Registry, Reykjavik, Iceland. 5Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Pathology, Landspitali National-University Hospital, Reykjavik, Iceland. (Elsevier, 2021-05-27)
    • Reply: Why does fetal head rotation occur in spontaneous labor?

      Hjartardóttir, Hulda; Eggebø, Torbjørn M; 1Department of Obstetrics and Gynecology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Electronic address: huldahj@simnet.is. 2National Center for Fetal Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger, Norway. (Elsevier, 2021-07-09)
    • Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome.

      Claesson, J; Freundlich, M; Gunnarsson, I; Laake, J H; M?ller, M H; Vandvik, P O; Varpula, T; Aasmundstad, T A; [ 1 ] Umea Univ, Anaesthesiol & Intens Care Med, Umea, Sweden [ 2 ] Univ Hosp Umea, Umea, Sweden [ 3 ] Aalborg Univ Hosp, Anaesthesiol, Aalborg, Denmark [ 4 ] Landspitali Univ Hosp, Anaesthesiol & Intens Care Med, Reykjavik, Iceland ??Organization-Enhanced Name(s) ???? Landspitali National University Hospital [ 5 ] Oslo Univ Hosp, Div Crit Care, Anaesthesiol, Oslo, Norway [ 6 ] Rigshosp, Copenhagen Univ Hosp, Intens Care 4131, Copenhagen, Denmark [ 7 ] Innlandet Hosp Trust Div Gjovik, Med, Gjovik, Norway [ 8 ] Norwegian Knowledge Ctr Hlth Serv, Oslo, Norway [ 9 ] Helsinki Univ Hosp, Intens Care Med, Helsinki, Finland (Wiley-Blackwell, 2016-07)
      The objective of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI) task force on fluid and drug therapy in adults with acute respiratory distress syndrome (ARDS) was to provide clinically relevant, evidence-based treatment recommendations according to standards for trustworthy guidelines.
    • A selective deficit for reading vowels in a letter-by-letter reader

      Jonsdottir, M K (Sveriges neuropsykologers förening, 2004-11)
      BM, a patient with fluent aphasia and severe alexia without agraphia is presented. He manifests a clear word length effect which is the hallmark of letter-by-letter reading. However, this letter-by-letter reader comes with an unusual twist, namely a selective difficulty in reading vowels, both in words and non-words. BM´s reading was not influenced by word class, imageability or word frequency. Only one other similar case is known in the literature.
    • Self-reported exposure to traffic pollution in relation to daytime sleepiness and habitual snoring: a questionnaire study in seven North-European cities.

      Gislason, Thorarinn; Bertelsen, Randi J; Real, Francisco Gomez; Sigsgaard, Torben; Franklin, Karl A; Lindberg, Eva; Janson, Christer; Arnardottir, Erna Sif; Hellgren, Johan; Benediktsdottir, Bryndis; et al. (Elsevier Science, 2016-08)
      Little is known about associations between traffic exposure and sleep disturbances. We examined if self-reported exposure to traffic is associated with habitual snoring and daytime sleepiness in a general population.
    • Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts.

      Knevel, R; de Rooy, D P; Gregersen, P K; Lindqvist, E; Wilson, A G; Gröndal, G; Zhernakova, A; van Nies, J A; Toes, R E; Tsonaka, R; et al. (2012-10)
    • T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.

      Chapuis, Aude G; Egan, Daniel N; Bar, Merav; Schmitt, Thomas M; McAfee, Megan S; Paulson, Kelly G; Voillet, Valentin; Gottardo, Raphael; Ragnarsson, Gunnar B; Bleakley, Marie; et al. (Nature Publishing Group, 2019-07)
      Relapse after allogeneic hematopoietic cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) entering HCT with poor-risk features1-3. When HCT does produce prolonged relapse-free survival, it commonly reflects graft-versus-leukemia effects mediated by donor T cells reactive with antigens on leukemic cells4. As graft T cells have not been selected for leukemia specificity and frequently recognize proteins expressed by many normal host tissues, graft-versus-leukemia effects are often accompanied by morbidity and mortality from graft-versus-host disease5. Thus, AML relapse risk might be more effectively reduced with T cells expressing receptors (TCRs) that target selected AML antigens6. We therefore isolated a high-affinity Wilms' Tumor Antigen 1-specific TCR (TCRC4) from HLA-A2+ normal donor repertoires, inserted TCRC4 into Epstein-Bar virus-specific donor CD8+ T cells (TTCR-C4) to minimize graft-versus-host disease risk and enhance transferred T cell survival7,8, and infused these cells prophylactically post-HCT into 12 patients ( NCT01640301 ). Relapse-free survival was 100% at a median of 44 months following infusion, while a concurrent comparative group of 88 patients with similar risk AML had 54% relapse-free survival (P = 0.002). TTCR-C4 maintained TCRC4 expression, persisted long-term and were polyfunctional. This strategy appears promising for preventing AML recurrence in individuals at increased risk of post-HCT relapse.
    • Thromboprophylaxis in multiple myeloma: is the evidence there?

      Kristinsson, Sigurdur Yngvi; Landgren, Ola (2012)