Recent Submissions

  • Reply to Amit Bansal, Ruchir Maheshwari, and Anant Kumar's Letter to the Editor re: Fredrik Liedberg, Petter Kollberg, Marie Allerbo, et al. Preventing Parastomal Hernia After Ileal Conduit by the Use of a Prophylactic Mesh: A Randomised Study. Eur Urol 2020;78:757-63.

    Liedberg, Fredrik; Kollberg, Petter; Allerbo, Marie; Baseckas, Gediminas; Brändstedt, Johan; Gudjonsson, Sigurdur; Hagberg, Oskar; Håkansson, Ulf; Jerlström, Tomas; Löfgren, Annica; et al. (Elsevier, 2020-12-31)
  • Anti-tumor necrosis factor therapy is associated with increased in situ squamous cell carcinoma of the skin: A population-based case-control study.

    Adalsteinsson, Jonas A; Muzumdar, Sonal; Waldman, Reid; Hu, Chaoran; Wu, Rong; Ratner, Désirée; Ungar, Jonathan; Silverberg, Jonathan I; Olafsdottir, Gudridur H; Kristjansson, Arni Kjalar; et al. (MOSBY-ELSEVIER, 2020-11-27)
  • International comparisons and holistic patient care.

    Zeitlin, J; Durox, M; Macfarlane, A; Alexander, S; Heller, G; Loghi, M; Nijhuis, J; Sól Ólafsdóttir, H; Mierzejewska, E; Gissler, M; et al. (Wiley, 2021-06-05)
  • Database Studies on Drug-Induced Liver Injury: The Importance of Causality Assessment.

    Björnsson, Helgi K; Björnsson, Einar S; 1Department of Internal Medicine, Section of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland. 2Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. (Wolters Kluwer Health, 2021-05)
  • Reply to Deepansh Dalela, Isaac Palma-Zamora, and Craig Rogers' Letter to the Editor re: Fredrick Leidberg, Petter Kollberg, Marie Allerbo, et al. Preventing Parastomal Hernia After Ileal Conduit by the Use of a Prophylactic Mesh: A Randomised Study. Eur Urol 2020;78:757-63.

    Liedberg, Fredrik; Kollberg, Petter; Allerbo, Marie; Baseckas, Gediminas; Brändstedt, Johan; Gudjonsson, Sigurdur; Hagberg, Oskar; Håkansson, Ulf; Jerlström, Tomas; Löfgren, Annica; et al. (Elsevier, 2021-01-25)
  • No transmission of SARS-CoV-2 to 23 healthcare professionals involved in advanced life support of COVID-19 patient - association with low viral RNA in respiratory specimens.

    Ingason, Arnar B; Jóhannesson, Jón M; Halldórsson, Jón T; Júlíusson, Unnsteinn I; Halldórsdóttir, Áslaug; Böðvarsson, Ásgeir; 1Husavik Hospital and Health Care Center, Husavik, Iceland. 2University of Iceland, Faculty of Medicine, Iceland. 3Department of Internal Medicine, Landspitali University Hospital, Iceland. 4Akureyri Primary Health Care Center, Akureyri, Iceland. (Taylor & Francis, 2020-08-21)
  • Berkjuskúlk – yfirlit

    Gunnar Guðmundsson; Gunnar Júlíusson; 1 Lungnadeild Landspítala, 2 læknadeild Háskóla Íslands, 3 röntgendeild Karólínska Háskólasjúkrahúsins í Stokkhólmi, Svíþjóð. (Læknafélag Íslands, 2020-07)
    Berkjuskúlk er sjúkdómur þar sem berkjur verða óeðlilega víðar og um er að ræða viðvarandi ástand. Þetta getur verið staðbundið eða dreift um bæði lungu. Sjúkdómurinn kemur á öllum aldri og veldur hósta með uppgangi og endurteknum sýkingum. Tíðni er hærri hjá konum og vex með aldri. Hann einkennist af endurteknum tímabilum þar sem einkenni versna mikið og gerist það oftast vegna sýkinga. Berkjuskúlk getur verið af óþekktum orsökum en getur tengst fjöldamörgum sjúkdómum bæði í lungum og utan þeirra. Sem dæmi um slíka sjúkdóma eru astmi, langvinn lungnateppa og liðagigt auk þess sem brestir í ónæmiskerfi tengjast berkjuskúlki. Þannig er sjúkdómsmynd ólík milli einstaklinga. Greining fæst með tölvusneiðmynd af lungum til viðbótar við klínísk einkenni. Uppvinnsla til að greina aðra sjúkdóma sem hafa tengsl við berkjuskúlk er mikilvæg. Í því sambandi er sögutaka, líkamsskoðun og frekari rannsóknir mikilvægar. Sjúklingar með berkjuskúlk hafa skert heilsutengd lífsgæði og styttar lífslíkur. Meðferð er fólgin í meðferð undirliggjandi sjúkdóma, sýklalyfjum og loftvegahreinsun. Lungnaendurhæfing og reglulegt eftirlit eru einnig mikilvæg. Í þessari grein verður gefið yfirlit um berkjuskúlk sem nýtist mörgum læknum í daglegu starfi því sjúkdómurinn sést víða, bæði hjá heimilislæknum, á sjúkrahúsum og utan sjúkrahúsa.
  • Ashwagandha as a cause for liver injury.

    Björnsson, Helgi K; Björnsson, Einar S; Avula, Bharathi; Khan, Ikhlas A; Jonasson, Jon G; Ghabril, Marwan; Hayashi, Paul H; Navarro, Victor; 1Landspitali University Hospital, Reykjavik, Iceland. 2National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi, USA. 3Indiana University School of Medicine, Indianapolis, Indiana, USA. 4University of North Carolina, Chapel Hill, North Carolina, USA. 5Einstein Healthcare Network, Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA. (Wiley, 2020-05-31)
  • Introducing the ReDO-TM programme and the ValMO-model in the Icelandic context

    Erlandsson, Lena-Karin; Halmstad University Sweden (Iðjuþjálfafélag Íslands, 2019)
  • Activity calculator: a method for achieving a balanced lifestyle for people with chronic fatigue

    Pinxsterhuis, Irma; Hulstein – van Gennep, Greke; ten Hove-Moerdijk, Karin; Hellesøy, Kirsti (Iðjuþjálfafélag Íslands, 2019)
  • COPD: Should Diagnosis Match Physiology?

    Studnicka, Michael; Horner, Andreas; Sator, Lea; Buist, A Sonia; Lamprecht, Bernd; 1Department of Pulmonary Medicine, Paracelsus Medical University, Salzburg, Austria. 2Department of Pulmonology, Kepler University Hospital, Linz, Austria; Faculty of Medicine, Johannes-Kepler-University, Salzburg, Austria; Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Portland, OR. Electronic address: andreas.horner@kepleruniklinikum.at. 3Oregon Health & Science University, Linz, Austria. 4Department of Pulmonology, Kepler University Hospital, Linz, Austria; Faculty of Medicine, Johannes-Kepler-University, Salzburg, Austria. (Elsevier, 2020-02)
  • Long-term Outcome of Implantable Cardioverter/Defibrillator Lead Failure.

    Davidsson, Gustav Arnar; Jonsdottir, Gudlaug M; Oddsson, Hjortur; Lund, Sigrun H; Arnar, David O; 1Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 2Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. (American Medical Association, 2019-12-20)
    This study compares outcomes of a recalled implantable cardioverter/defibrillator lead with a control lead in individuals in Iceland.
  • Effective treatment with balneophototherapy and narrowband UVB monotherapy reduces skin homing Th17/Tc17 and Th22/Tc22 effector cells in peripheral blood in patients with psoriasis.

    Eysteinsdóttir, Jenna Huld; Sigurgrímsdóttir, Hildur; Einarsdóttir, Helga Kristín; Freysdottir, Jona; Agnarsson, Bjarni A; Ólafsson, Jón Hjaltalín; Sigurgeirsson, Bárður; Lúðvíksson, Björn Rúnar; 1Faculty of Medicine, University of Iceland, Reykjavík, Iceland. Electronic address: jenna@hudlaeknastodin.is. 2Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Department of Immunology, Landspitali - The National University Hospital of Iceland, Reykjavík, Iceland. 3Department of Immunology, Landspitali - The National University Hospital of Iceland, Reykjavík, Iceland. 4Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Department of Immunology, Landspitali - The National University Hospital of Iceland, Reykjavík, Iceland; Centre for Rheumatology Research, Landspitali - The National University Hospital of Iceland, Reykjavík, Iceland. 5Department of Pathology, Landspitali - The National University Hospital of Iceland, Reykjavík, Iceland. 6Faculty of Medicine, University of Iceland, Reykjavík, Iceland. (ELSEVIER IRELAND, 2019-10-15)
  • Haploinsufficiency of KMT2D is sufficient to cause Kabuki syndrome and is compatible with life.

    Luperchio, Teresa Romeo; Applegate, Carolyn D; Bodamer, Olaf; Bjornsson, Hans Tomas; 1 McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2 Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. 3 Broad Institute of MIT and Harvard University, Cambridge, MA, USA. 4 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 5 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 6 Landspitali University Hospital, Reykjavik, Iceland. (Wiley, 2019-12-08)
    We present the first patient described with haploinsufficency of KMT2D leading to Kabuki syndrome. Deletion of KMT2D has been thought to be lethal, but here we describe a patient with KMT2D deletion and classical Kabuki syndrome phenotype.
  • Greetings from the land of snow where the hot springs glow.

    Arnarson, Eirikur Orn; University of Iceland (Association for Behavioral and Cognitive Therapies; US, 2016-10)
  • The Process of Writing When English is Your Second Language

    Svavarsdottir, Erla Kolbrún; Faculty of Nursing, School of Health Sciences, University of Iceland (UI) and at Landspitali University Hospital (LUH) (Wiley-Blackwell, 2016-10)
  • Correction to: Variability in functional outcome and treatment practices by treatment center after out-of-hospital cardiac arrest: analysis of International Cardiac Arrest Registry.

    May, Teresa L; Lary, Christine W; Riker, Richard R; Friberg, Hans; Patel, Nainesh; Søreide, Eldar; McPherson, John A; Undén, Johan; Hand, Robert; Sunde, Kjetil; et al. (Springer, 2019-08)
  • T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.

    Chapuis, Aude G; Egan, Daniel N; Bar, Merav; Schmitt, Thomas M; McAfee, Megan S; Paulson, Kelly G; Voillet, Valentin; Gottardo, Raphael; Ragnarsson, Gunnar B; Bleakley, Marie; et al. (Nature Publishing Group, 2019-07)
    Relapse after allogeneic hematopoietic cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) entering HCT with poor-risk features1-3. When HCT does produce prolonged relapse-free survival, it commonly reflects graft-versus-leukemia effects mediated by donor T cells reactive with antigens on leukemic cells4. As graft T cells have not been selected for leukemia specificity and frequently recognize proteins expressed by many normal host tissues, graft-versus-leukemia effects are often accompanied by morbidity and mortality from graft-versus-host disease5. Thus, AML relapse risk might be more effectively reduced with T cells expressing receptors (TCRs) that target selected AML antigens6. We therefore isolated a high-affinity Wilms' Tumor Antigen 1-specific TCR (TCRC4) from HLA-A2+ normal donor repertoires, inserted TCRC4 into Epstein-Bar virus-specific donor CD8+ T cells (TTCR-C4) to minimize graft-versus-host disease risk and enhance transferred T cell survival7,8, and infused these cells prophylactically post-HCT into 12 patients ( NCT01640301 ). Relapse-free survival was 100% at a median of 44 months following infusion, while a concurrent comparative group of 88 patients with similar risk AML had 54% relapse-free survival (P = 0.002). TTCR-C4 maintained TCRC4 expression, persisted long-term and were polyfunctional. This strategy appears promising for preventing AML recurrence in individuals at increased risk of post-HCT relapse.
  • Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort.

    Mendel, Arielle; Bernatsky, Sasha B; Hanly, John G; Urowitz, Murray B; Clarke, Ann Elaine; Romero-Diaz, Juanita; Gordon, Caroline; Bae, Sang-Cheol; Wallace, Daniel J; Merrill, Joan T; et al. (BMJ Publishing Group, 2019-07)
  • Anaplastic thyroid carcinoma transformation in a lateral neck node metastasis - A case report and a review of the literature

    Gunnarsdottir, Agnes B; Briem, Birgir A; Jonasson, Larus; Tryggvason, Geir; [ 1 ] Skanes Univ Sjukhus Lund, Dept Otolaryngol & Head & Neck Canc, Lund, Sweden Show more [ 2 ] Landspitali Univ Hosp, Dept Otolaryngol Head & Neck Surg, IS-108 Reykjavik, Iceland Show more [ 3 ] Landspitali Univ Hosp, Dept Surg Pathol, Reykjavik, Iceland (Taylor & Francis, 2018)
    Anaplastic thyroid carcinoma is thought to be derived from previous existing papillary or follicular thyroid carcinoma that dedifferentiates into its anaplastic counterpart. We present a case where this type of dedifferentiation occurs at a metastatic site in a regional lymph node, years after the primary papillary thyroid tumor had metastasized.

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