Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformis
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationPhytomedicine 2007, 14(2-3):179-84
AbstractThree heteroglycans Ths-4, Ths-5 and thamnolan and a beta-glucan, Ths-2, isolated from the lichen Thamnolia vermicularis var. subuliformis were tested for in vitro immunomodulating activities and shown to have various influences on the immune system. All the polysaccharides except Ths-4 caused a stimulation of rat spleen cell proliferation. In contrast, Ths-4 caused cell death early in the culture, probably due to over-stimulation. Moreover, the galactofuranomannans, Ths-4, Ths-5 and the beta-glucan Ths-2, induced rat spleen cells to secrete IL-10 significantly above background levels. In addition, Ths-4 and Ths-5 stimulated significant TNF-alpha secretion by rat peritoneal macrophages. The galactofuranomannans Ths-4 and Ths-5 have similar structures apart from the molecular weight. Thus, it may be concluded that the molecular size might influence the potency but not the pattern of activity for Ths-4 and Ths-5. The galactofuranorhamnan thamnolan had less mitogenic effect than Ths-5 and Ths-2 and neither induced IL-10 secretion by rat spleen cells nor TNF-alpha secretion by peritoneal macrophages to significant levels. This shows that thamnolan with its unusual galactofuranorhamnan structure differs from the other Thamnolia polysaccharides in its immunomodulatory activity.
DescriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links field
- Effects of lichen heteroglycans on proliferation and IL-10 secretion by rat spleen cells and IL-10 and TNF-alpha secretion by rat peritoneal macrophages in vitro.
- Authors: Omarsdottir S, Freysdottir J, Barsett H, Paulsen BS, Olafsdottir ES
- Issue date: 2005 Jun
- Immunologically active O6-branched (1-->3)-beta-glucan from the lichen Thamnolia vermicularis var. subuliformis.
- Authors: Olafsdottir ES, Omarsdottir S, Paulsen BS, Wagner H
- Issue date: 2003 May
- Structural characterisation of novel lichen heteroglycans by NMR spectroscopy and methylation analysis.
- Authors: Omarsdottir S, Petersen BO, Paulsen BS, Togola A, Duus JØ, Olafsdottir ES
- Issue date: 2006 Oct 16
- Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cells.
- Authors: Omarsdottir S, Olafsdottir ES, Freysdottir J
- Issue date: 2006 Nov
- Rhamnopyranosylgalactofuranan, a new immunologically active polysaccharide from Thamnolia subuliformis.
- Authors: Olafsdottir ES, Omarsdottir S, Paulsen BS, Jurcic K, Wagner H
- Issue date: 1999 Oct