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dc.contributor.authorOlafsdottir, E
dc.contributor.authorWestgard, J O
dc.contributor.authorEhrmeyer, S S
dc.contributor.authorFallon, K D
dc.date.accessioned2010-10-04T15:42:08Z
dc.date.available2010-10-04T15:42:08Z
dc.date.issued1996-03-01
dc.date.submitted2010-10-04
dc.identifier.citationClin. Chem. 1996, 42(3):392-6en
dc.identifier.issn0009-9147
dc.identifier.pmid8598101
dc.identifier.urihttp://hdl.handle.net/2336/112257
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe have assessed how variation in the matrix of control materials would affect error detection and false-rejection characteristics of quality-control (QC) procedures used to monitor PO2 in blood gas measurements. To determine the expected QC performance, we generated power curves for S(mat)/S(meas) ratios of 0.0-4.0. These curves were used to estimate the probabilities of rejecting analytical runs having medically important errors, calculated from the quality required by the CLIA '88 proficiency testing criterion and the precision and accuracy expected for a typical analytical system. When S(mat)/S(meas) ratios are low, the effects of matrix on QC performance are not serious, permitting selections of QC procedures based on simple power curves for a single component of variation. As S(mat)/S(meas) ratios increase, single-rule procedures generally show a loss in error detection, whereas multirule procedures, including the 3(1)s control rule, show an increase in false rejections. An optimized QC design is presented.
dc.language.isoenen
dc.publisherAmerican Association for Clinical Chemistry, Incen
dc.relation.urlhttp://www.clinchem.org/cgi/content/abstract/42/3/392en
dc.subject.meshBlood Gas Analysisen
dc.subject.meshComputer Simulationen
dc.subject.meshHumansen
dc.subject.meshOxygenen
dc.subject.meshQuality Controlen
dc.subject.meshSensitivity and Specificityen
dc.titleMatrix effects and the performance and selection of quality-control procedures to monitor PO2 measurementsen
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Biochemistry, Landspitalinn, University Hospital, Reykjavik, Iceland.en
dc.identifier.journalClinical chemistryen
html.description.abstractWe have assessed how variation in the matrix of control materials would affect error detection and false-rejection characteristics of quality-control (QC) procedures used to monitor PO2 in blood gas measurements. To determine the expected QC performance, we generated power curves for S(mat)/S(meas) ratios of 0.0-4.0. These curves were used to estimate the probabilities of rejecting analytical runs having medically important errors, calculated from the quality required by the CLIA '88 proficiency testing criterion and the precision and accuracy expected for a typical analytical system. When S(mat)/S(meas) ratios are low, the effects of matrix on QC performance are not serious, permitting selections of QC procedures based on simple power curves for a single component of variation. As S(mat)/S(meas) ratios increase, single-rule procedures generally show a loss in error detection, whereas multirule procedures, including the 3(1)s control rule, show an increase in false rejections. An optimized QC design is presented.


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