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      The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

      Forzano, Francesca; Antonova, Olga; Clarke, Angus; de Wert, Guido; Hentze, Sabine; Jamshidi, Yalda; Moreau, Yves; Perola, Markus; Prokopenko, Inga; Read, Andrew; et al. (SPRINGER NATURE, 2021-12-17)
      Y Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.
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      Liver Injury Following Tinospora Cordifolia Consumption: Drug-Induced AIH, or AIH?

      Björnsson, Einar S; Navarro, Victor J; Chalasani, Naga; 1Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland. 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 3Department of Medicine, Einstein Health Care Network, Jefferson Health, Philadelphia, PA, USA. 4Division of Gastroenterology and Hepatology, Indianapolis, IN, USA. (Elsevier, 2021-11-29)
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      A policy for diversity, equity, inclusion and anti-racism in the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI).

      Laake, Jon H; Astvad, Mads; Bentsen, Gunnar; Escher, Cecilia; Haney, Michael; Hoffmann-Petersen, Joachim; Hyllested, Mette; Junttila, Eija; Møller, Morten H; Nellgård, Per; et al. (Wiley, 2021-08-30)
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      The state of your journal Acta Ophthalmologica 2020

      Kaarniranta, Kai; Stefánsson, Einar; a Department of Ophthalmology, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland b Department of Ophthalmology, National University Hospital, University of Iceland, Reykjavík, Iceland (Wiley, 2021-08-01)
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      Successful years of collaboration between Acta Ophthalmologica and the European Association for Vision and Eye Research.

      Kaarniranta, Kai; Stefansson, Einar; 1Department of Ophthalmology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. 2Department of Ophthalmology, University of Iceland, National University Hospital, Reykjavik, Iceland. (Wiley, 2021-05)
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      Liver Injury Associated With Drugs and Complementary and Alternative Medicines in India.

      Björnsson, Einar S; 1Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland. 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland. (Elsevier, 2021-04-27)
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      Unexplained sudden death: next-generation sequencing to the rescue?

      Arnadottir, Gudny A; Arnar, David O; 1Decode Genetics/Amgen, Reykjavik, Iceland. 2Division of Cardiology, Cardiovascular Centre, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 3Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. (Oxford University Press, 2021-03)
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      The most successful year in the history of Acta Ophthalmologica.

      Kaarniranta, Kai; Stefánsson, Einar; 1Department of Ophthalmology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. 2Department of Ophthalmology, University of Iceland and National University Hospital, Reykjavik, Iceland. (Wiley, 2021-03)
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      Iodinated contrast for patients with chronic kidney disease-writing on the wall or free for all?

      Helgason, Dadi; Sigurdsson, Martin I.; [ 1 ]‎ Natl Univ Hosp Iceland, Landspitali, Internal Med Serv, Reykjavik, Iceland Show more [ 2 ]‎ Natl Univ Hosp Iceland, Landspitali, Div Anesthesia & Intens Care Med, Reykjavik, Iceland Show more [ 3 ]‎ Univ Iceland, Fac Med, Reykjavik, Iceland (AME Publishing Company, 2021-02-01)
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      Liver Injury Associated with the Selective Progesterone Modulator Ulipristal.

      Björnsson, Einar S; 1Department of Internal Medicine, Division of Gastroenterology and Hepatology, Landspitali University Hospital, Hringbraut, Building H 101, Reykjavík, Iceland. einarsb@landspitali.is. 2Faculty of Medicine, University of Iceland, Reykjavík, Iceland. einarsb@landspitali.is. (Adis, Springer International, 2020-10-09)
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      The Establishment of the Nordic Cardio-Oncology Society

      Tuohinen, Suvi; Skytta, Tanja; Geisler, Jürgen; Hrafnkelsdóttir, þórdís Jóna; Smáradóttir, Agnes; Nielsen, Kirsten Melgaard; Offersen, Birgitte V.; Jarfelt, Marianne; Gulati, Geeta; Broberg, Agneta Mansson; et al. (Elsevier, 2020-06-30)
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      Liver injury associated with the analgetic drug metamizole.

      Björnsson, Einar S; 1Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland. 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland. (Wiley, 2020-05-12)
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      Obesity as a modifiable risk factor for hypertrophic cardiomyopathy.

      Adalsteinsdottir, Berglind; Landspitali Natl Univ Hosp Iceland, Div Cardiol, Hringbraut 101, Reykjavik, Iceland (SAGE Publications, 2020-01-13)
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      Let the games begin: serious games in prevention and rehabilitation to improve outcomes in patients with cardiovascular disease

      Ingadottir, Brynja; Jaarsma, Tiny; Klompstra, Leonie; Aidemark, Jan; Askenäs, Linda; Bahat, Yotam; Ben Gal, Oran; Berglund, Aseel; Berglund, Erik; Höchsmann, Christoph; et al. (SAGE, 2020-01-01)
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      Treatment of non-infectious ophthalmic inflammatory diseases with 1.5% dexamethasone γ-cyclodextrin nanoparticle eye drops.

      Imamachi, Katsue; Stefánsson, Einar; Ohira, Akihiro; Tanito, Masaki; 1 Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan. 2 Department of Ophthalmology, Faculty of Medicine, National University Hospital, University of Iceland, Reykjavik, Iceland. (Wiley, 2019-12)
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      Change in Albuminuria and Estimated GFR as End Points for Clinical Trials in Early Stages of CKD: A Perspective From European Regulators.

      Holtkamp, Frank; Gudmundsdottir, Hrefna; Maciulaitis, Romaldas; Benda, Norbert; Thomson, Andrew; Vetter, Thorsten; 1Dutch Medicines Evaluation Board, Utrecht, the Netherlands. 2Icelandic Medicines Agency, Reykjavík, Iceland; Landspitali - The National University Hospital of Iceland, Reykjavík, Iceland. 3Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania; Lithuanian State Medicines Control Agency, Kaunas, Lithuana. 4German Federal Institute for Drugs and Medical Devices, Bonn, Germany. 5European Medicines Agency, Amsterdam, the Netherlands. 6European Medicines Agency, Amsterdam, the Netherlands. Electronic address: thorsten.vetter@ema.europa.eu. (W.B. Saunders, 2019-10-28)
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      Producing valid statistics when legislation, culture, and medical practices differ for births at or before the threshold of survival: Report of a European workshop.

      Smith, L K; Blondel, B; Zeitlin, J; 1 Department of Health Sciences, College of Life Sciences, University of Leicester, Leicester, UK. 2 Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Centre for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France. (Wiley, 2019-10-03)
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      Ethical issues in precision medicine.

      Jonsson, Jon J; Stefansdottir, Vigdis; 1) Department of Genetics and Molecular Medicine, Landspitali - National University Hospital, Reykjavik, Iceland. 2) Department of Biochemistry and Molecular Biology, University of Iceland, Reykjavik, Iceland. (Sage Publications, 2019-09-04)
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      Lessons learnt from anonymized review of cases of peripartum hysterectomy by international experts: A qualitative pilot study.

      Jónasdóttir, Eva; Aabakke, Anna J M; Colmorn, Lotte B; Jakobsson, Maija; Äyräs, Outi; Baghestan, Elham; Svanvik, Teresia; van den Akker, Thomas; Bloemenkamp, Kitty; van Roosmalen, Jos; et al. (Wiley, 2019-08)
      Severe obstetric complications are not extensively studied and individual cases are used too little and inappropriately in quality improvement activities, due to limited numbers and prioritization of quantitative research. Nordic and European experts performed a qualitative pilot study using anonymized cases of peripartum hysterectomy. It was feasible to anonymize narratives and we learned lessons in the form of themes for improved clinical care and future research. Therefore, we plan a Nordic anonymized review of the care of women who have undergone peripartum hysterectomy based on narratives. The qualitative outcomes of clinically relevant themes for quality improvement and research will add value to the quantitative analyses from the Nordic medical birth registries. In the longer term, we believe that qualitative audits should be an essential part of the process of continuing improvement in maternity care.
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      In due time.

      Harðardóttir, Hildur; 1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Iceland and Landspitali University Hospital, Reykjavik, Iceland. (Wiley, 2019-08)
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