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dc.contributor.authorJonsson, T
dc.contributor.authorArinbjarnarson, S
dc.contributor.authorThorsteinsson, J
dc.contributor.authorSteinsson, K
dc.contributor.authorGeirsson, A J
dc.contributor.authorJonsson, H
dc.contributor.authorValdimarsson, H
dc.date.accessioned2010-10-12T09:19:48Z
dc.date.available2010-10-12T09:19:48Z
dc.date.issued1995
dc.date.submitted2010-10-12
dc.identifier.citationScand. J. Rheumatol. 1995, 24(6):372-5en
dc.identifier.issn0300-9742
dc.identifier.pmid8610222
dc.identifier.doi10.3109/03009749509095183
dc.identifier.urihttp://hdl.handle.net/2336/112816
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractIn rheumatoid arthritis (RA) seropositivity has been associated with poor prognosis including bone erosions and extra-articular manifestations. However, findings have been conflicting on the association between individual rheumatoid factor (RF) isotypes and extra-articular manifestations. In this study the occurrence of extra-articular manifestations was examined in the context of the RF isotype patterns rather than individual RF isotypes. IgM, IgG and IgA RF was measured by ELISA in 74 patients with RA and the findings correlated with the presence or absence of extra-articular manifestations. Of the IgA RF positive patients 80% had one or more extra-articular manifestations. In contrast, only 21% of patients with raised IgM and/or IgG RF but normal IgA RF had some extra-articular manifestations and 27% of the seronegative patients. It is concluded that the previously reported association between raised RF and extra-articular manifestations in RA can largely be attributed to the IgA RF isotype.
dc.language.isoenen
dc.publisherInforma Healthcareen
dc.relation.urlhttp://dx.doi.org/10.3109/03009749509095183en
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshArthritis, Rheumatoiden
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshImmunoglobulin Aen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshRheumatoid Factoren
dc.subject.meshRheumatoid Noduleen
dc.subject.meshSjogren's Syndromeen
dc.titleRaised IgA rheumatoid factor (RF) but not IgM RF or IgG RF is associated with extra-articular manifestations in rheumatoid arthritisen
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, National University Hospital, Landspítalinn, Reykjavík, Iceland.en
dc.identifier.journalScandinavian journal of rheumatologyen
html.description.abstractIn rheumatoid arthritis (RA) seropositivity has been associated with poor prognosis including bone erosions and extra-articular manifestations. However, findings have been conflicting on the association between individual rheumatoid factor (RF) isotypes and extra-articular manifestations. In this study the occurrence of extra-articular manifestations was examined in the context of the RF isotype patterns rather than individual RF isotypes. IgM, IgG and IgA RF was measured by ELISA in 74 patients with RA and the findings correlated with the presence or absence of extra-articular manifestations. Of the IgA RF positive patients 80% had one or more extra-articular manifestations. In contrast, only 21% of patients with raised IgM and/or IgG RF but normal IgA RF had some extra-articular manifestations and 27% of the seronegative patients. It is concluded that the previously reported association between raised RF and extra-articular manifestations in RA can largely be attributed to the IgA RF isotype.


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